Results 51 to 60 of about 382,251 (299)

Composite scaffolds for bone tissue engineering [PDF]

, 2006
Biomaterial and scaffold development underpins the advancement of tissue engineering. Traditional scaffolds based on biodegradable polymers such as poly(lactic acid) and poly(lactic acid-co-glycolic acid) are weak and non-osteoconductive. For bone tissue
Wang, M
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Nanotechnology in bone tissue engineering [PDF]

Nanomedicine: Nanotechnology, Biology and Medicine, 2015
Nanotechnology represents a major frontier with potential to significantly advance the field of bone tissue engineering. Current limitations in regenerative strategies include impaired cellular proliferation and differentiation, insufficient mechanical strength of scaffolds, and inadequate production of extrinsic factors necessary for efficient ...
Graham G, Walmsley, Adrian, McArdle, Ruth, Tevlin, Arash, Momeni, David, Atashroo, Michael S, Hu, Abdullah H, Feroze, Victor W, Wong, Peter H, Lorenz, Michael T, Longaker, Derrick C, Wan   +10 more
openaire   +2 more sources

Biodegradable Polymers in Bone Tissue Engineering [PDF]

, 2009
The use ofdegradable polymers in medicine largely started around the mid 20th century with their initial use as in vivo resorbing sutures. Thorough knowledge on this topic as been gained since then and the potential applications for these polymers were ...
Bostman, Brodbeck, Busam, Choueka, Curran, de Boer, Eglin, Govaert, Gunatillake, Gunatillake, Holland, Hunt, Koort, Leon Govaert, Makinen, Marco Helder, Nair, Pietrzak, Robert Kroeze, Seiler, Story, Summers, Theo Smit, Togawa, Vaccaro, Vaccaro, Van Dijk, Vert, Williams, Wnek, Wright, Wuisman, Yamada, Young   +33 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Pharmaceuticals, 2021
Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to ...
Anand Mohan, Madhuri Girdhar, Raj Kumar, Harshil S. Chaturvedi, Agrataben Vadhel, Pratima R. Solanki, Anil Kumar, Deepak Kumar, Narsimha Mamidi   +8 more
doaj   +1 more source

Fractal geometry of nature (bone) may inspire medical devices shape [PDF]

, 2010
Medical devices, as orthopaedics prostheses and dental implants, have been designed over years on the strength of mechanical, clinical and biological indications.
Matteo Sartori, Salvatore Longoni
core   +1 more source

A Tissue Engineering product development pathway [PDF]

, 2012
Tissue engineering is a field of inquiry and research that uses engineering techniques and principles of biological sciences to develop functional substitutes for reconstruction of damaged organs.
Falvo D'Urso Labate, Giuseppe Vittorio Ugo
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Micro computed tomography based finite element models of calcium phosphate scaffolds for bone tissue engineering [PDF]

, 2016
Bone is a living tissue that is able to regenerate by itself. However, when severe bone defects occur, the natural regeneration may be impaired. In these cases, bone graft substitutes can be used to induce the natural healing process.
Jung, Timo Karl
core