Results 51 to 60 of about 7,636,676 (293)
Towards bone graft manufacturing via endochondral ossification [PDF]
, 2012 In tissue engineering field, conventional manufacturing processes for graft generation have been recently challenged by new insights in basic biology, technological tools and clinical demands.
Tonnarelli, Beatrice
core +1 more source
Tissue engineered bone as an alternative for repairing bone defects
Dental Journal, 2010 Background: Dentist especially oral surgeon, are frequently faced with defect in bone resulting from disease or trauma. If the defect is small, it will frequently has a good healing, however, if the defect is larger, incomplete regeneration often occurs ...
Evy Eida Vitria, Benny S. Latif
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Magnetic Nanoparticles in Bone Tissue Engineering
Nanomaterials, 2022 Large bone defects with limited intrinsic regenerative potential represent a major surgical challenge and are associated with a high socio-economic burden and severe reduction in the quality of life. Tissue engineering approaches offer the possibility to
Akshith Dasari, Jingyi Xue, Sanjukta Deb
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bone tissue engineering in osteoporosis
Maturitas, 2013 Osteoporosis is a polygenetic, environmentally modifiable disease, which precipitates into fragility fractures of vertebrae, hip and radius and also confers a high risk of fractures in accidents and trauma. Aging and the genetic molecular background of osteoporosis cause delayed healing and impair regeneration.
Franz Jakob +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Polymeric Scaffolds for Bone Tissue Engineering [PDF]
, 2004 Bone tissue engineering is a rapidly developing area. Engineering bone typically uses an artificial extracellular matrix (scaffold), osteoblasts or cells that can become osteoblasts, and regulating factors that promote cell attachment, differentiation ...
Liu, Xiaohua, Ma, Peter X.
core +1 more source
Cell Scaffolds for Bone Tissue Engineering
Bioengineering, 2020 Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft ...
Kazutoshi Iijima, Hidenori Otsuka
doaj +1 more source