Results 61 to 70 of about 382,251 (299)
Accuracy and Mechanical Properties of Open-Cell Microstructures Fabricated by Selective Laser Sintering [PDF]
, 2007 This paper investigates the applicability of selective laser sintering (SLS) for the manufacture of scaffold geometries for bone tissue engineering applications.
Eosoly, S. +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells
, 2011 Modern tissue engineering strategies combine living cells and scaffold materials to develop biological substitutes that can restore tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their ...
Ahn, Jong-Hyun +10 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION
Journal of Stem Cell Research and Tissue Engineering, 2018 Maxillofacial bone defects due to tumor resection, trauma or infections should be reconstructed to maintain the bone continuity in order to preserve its masticatory, speech and esthetic functions.
David Kamadjaja
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Scientific ReportsFemoral head necrosis (FHN) is a serious complication after femoral neck fractures (FNF), often linked to sclerosis around screw paths. Our study aimed to uncover the proteomic and metabolomic underpinnings of FHN and sclerosis using integrated ...
Yang Liu +9 more
doaj +1 more source
Continuum Modeling and Simulation in Bone Tissue Engineering [PDF]
, 2019 Bone tissue engineering is currently a mature methodology from a research perspective. Moreover, modeling and simulation of involved processes and phenomena in BTE have been proved in a number of papers to be an excellent assessment tool in the stages ...
Reina Romo, Esther +1 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Cell Scaffolds for Bone Tissue Engineering
Bioengineering, 2020 Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft ...
Kazutoshi Iijima, Hidenori Otsuka
doaj +1 more source