Results 91 to 100 of about 2,694,526 (308)

Bone sarcoma cumulative tumor rates in patients injected with 224Ra [PDF]

, 1986
Auf Grund eines Druckfehlers sind die Seiten 28-29 in der Druckvorlage nicht ...
Gössner, Wolfgang, Kellerer, Albrecht M., Spiess, H., Chmelevsky, D., Mays, C. W.   +4 more
core   +1 more source

Influence of constraint mechanism on kinematics, contact mechanics, and polyethylene wear in dual-axis rotating hinge and ball-and-socket knee prostheses: a finite element study

Frontiers in Bioengineering and Biotechnology
BackgroundSevere metaphyseal bone defects following revision total knee arthroplasty or tumor resection often require highly constrained knee prostheses. Although rotating hinge knee (RHK) designs provide reliable stability, polyethylene wear and aseptic
Jinwei Liu, Xiaoyi Wang, Chuanhao Guo, Yongcheng Hu, Weiguo Xu, Jingyu Zhang   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk

Cancer Management and Research
Xiang Qi,1,* Shuai Hao,1,* Yue Sun,2,* Manglai Li,2 Jingyuan Yang,2 Lei Kang,3 Liansheng Zhang,2 Hairui Wang2 1Graduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, People’s Republic of ...
Qi X, Hao S, Sun Y, Li M, Yang J, Kang L, Zhang L, Wang H   +7 more
doaj  

Epidemiological Characteristics of 1196 Patients with Spinal Metastases: A Retrospective Study

Orthopaedic Surgery, 2019
Objectives To describe the epidemiological characteristics of patients with spinal metastases between 2007 and 2019. Methods Patients with spinal metastases were identified from several clinical centers in China between January 2007 and July 2019 ...
Feng Wang, Hao Zhang, Li Yang, Xiong‐gang Yang, Hao‐ran Zhang, Ji‐kai Li, Rui‐qi Qiao, Yong‐cheng Hu   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Proteomics in bone malignancies: from bulk profiling to single-cell and ultra-low-input technologies

Journal of Translational Medicine
Background Bone malignancies, particularly high-grade primary bone sarcomas, remain clinically challenging due to early dissemination, marked heterogeneity, and limited progress in systemic therapies for metastatic or relapsed disease. While genomics and
Jianming Chen, Jiaqiao Luo, Ning Ni, Jinhao Zhang, Lei Jiang, Hongbao Wu, Shenghao Wen, Ninghao Hu, Jiaran Li, Gang Deng, Shuxiang Song, Xiaomeng Shi   +11 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Correlations between cancellous bone architecture and its dynamic behaviour [PDF]

, 2014
Previous studies showed that in vivo evaluation of the fracture risk of cancellous bone can be assessed by identifying the relationships between its microarchitecture description extracted from clinical imaging and its mechanical properties.
LAPORTE, Sébastien, SALETTI, Dominique, PATTOFATTO, Stéphane, BOUSSON, Valérie, PROT, Marianne   +4 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source