Results 71 to 80 of about 2,694,526 (308)

Giant cell tumor of bone arising in long bones possibly originates from the metaphyseal region [PDF]

, 2016
Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of
Ishiguro, Naoki, Arai, Eisuke, Tsukushi, Satoshi, Nishida, Yoshihiro, Kozawa, Eiji, Urakawa, Hiroshi, Futamura, Naohisa   +6 more
core   +1 more source

Upregulation of long non-coding RNA SNHG11 promotes apoptosis and its molecular mechanisms in human osteosarcoma U2OS cells

Scientific Reports
Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin, which is common in children and adolescents. Long non-coding RNA (lncRNA) SNHG11 plays important regulatory roles in various cancers, particularly in promoting cell migration, invasion ...
Zhibing Dai, Yachao Sun, Maierdanjiang Maihemuti, JunWei Du, Renbing Jiang   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Identification of key targets and exploration of therapeutic molecular mechanisms of natural compound tangeretin in osteosarcoma

Discover Oncology
Introduction Osteosarcoma (OS) is an invasive and lethal malignancy showing a low 5 year survival rate, underscoring the need for identifying new therapeutic targets and their inhibitors to enhance prevention and treatment strategies.
Ruoping Yanzhang, Zhaojie Yang, Xiangping Li, Yin Yu, Ruifang Shen, Huijun Zhang, Ying Wu, Junyan Teng   +7 more
doaj   +1 more source

Use of percutaneous core needle biopsy for diagnosing acral bone tumors

Journal of Bone Oncology, 2017
This study aims to evaluate the diagnostic value of percutaneous core needle biopsy (PCNB) in diagnosing acral bone tumors. The clinical PCNB data of 341 patients with bone tumors were retrospectively analyzed.
Zhichao Tong, Mingyu Zhang, Bo Chen, Yujie Zhu, Jianfeng Wei, Xiaoju Li   +5 more
doaj   +1 more source

Research Progress of PD-1/PD-L1 Checkpoint Inhibitors in (Neo) Adjuvant Therapy for Malignant Melanoma

Zhongliu Fangzhi Yanjiu, 2020
Malignant melanoma is the most serious type of skin cancer with a high recurrence rate and death rate. Surgery still is the cornerstone of treatment for patients with stage Ⅱ and Ⅲ melanoma.
ZOU Hanhui, Li Tao
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Exploring functional mechanisms underlying tumor initiation, EMT and cell migration [PDF]

, 2012
Cancer is one of the leading causes of death. A primary tumor forms when cells start to proliferate in an uncontrolled way and stop reacting to restraining signals.
Gruber, Dorothea Cornelia
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source