Results 231 to 240 of about 973,694 (311)

Semi-supervised Label Generation for 3D Multi-modal MRI Bone Tumor Segmentation. [PDF]

J Imaging Inform Med
Curto-Vilalta A, Schlossmacher B, Valle C, Gersing A, Neumann J, von Eisenhart-Rothe R, Rueckert D, Hinterwimmer F.   +7 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Sonographic characteristics of local soft tissue recurrence in primary bone tumor and diagnostic efficacy versus MRI. [PDF]

BMC Cancer
Yu P, Gao J, Hu Y, Zhu J, Wang Y.
europepmc   +1 more source

Melanotic Neuroectodermal Tumor Presenting as Endolymphatic Sac Tumor. [PDF]

, 2019
Abouzari, Mehdi, Choy, Joseph, Djalilian, Hamid R, Linskey, Mark E, Mahboubi, Hossein   +4 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Utility of Same-Modality, Cross-Domain Transfer Learning for Malignant Bone Tumor Detection on Radiographs: A Multi-Faceted Performance Comparison with a Scratch-Trained Model. [PDF]

Cancers (Basel)
Hasei J, Nakahara R, Otsuka Y, Takeuchi K, Nakamura Y, Ikuta K, Osaki S, Tamiya H, Miwa S, Ohshika S, Nishimura S, Kahara N, Yoshida A, Kondo H, Fujiwara T, Kunisada T, Ozaki T.   +16 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Cavernous hemangioma of the rib mimicking malignant bone tumor: A case report. [PDF]

Radiol Case Rep
Mulugeta M, Muluken Y, Tamiru R, Hailemeskel EG, Nigussie B.   +4 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Bone tumor recognition strategy based on object region and context representation in medical decision-making system. [PDF]

Sci Rep
Liu Y, Liu J, Dai T, Gou F.
europepmc   +1 more source