Results 61 to 70 of about 585,221 (311)

PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases. [PDF]

, 2018
Metastatic breast cancer (BrCa) is currently incurable despite great improvements in treatment of primary BrCa. The incidence of skeletal metastases in advanced BrCa occurs up to 70%.
Wang, Bin, Yang, Yanmei
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Clinical study of separation surgery combined with intraoperative vertebroplasty and 125I seeds implantation for spinal metastases from lung adenocarcinoma with epidural spinal cord compression

World Journal of Surgical Oncology
Background The study aim was to evaluate the efficacy and safety of separation surgery combined with intraoperative vertebroplasty and125I seeds implantation for the treatment of lung adenocarcinoma-associated metastatic epidural spinal cord compression (
Ya Zhang, Bin Fan, Tiying Wang, Yihao Yang, Nabil Zia UI Haq, Zhou Huang, Dachang Xu, Yan Liu, Dongqi Li, Lei Han, Weiquan Wang, Linhao Cai, Xiaohui Yang, Hongpu Sun, Jing Zhang, Cao Wang, Tao Yuan, Xiang Ma, Zuozhang Yang   +18 more
doaj   +1 more source

LncRNA ZFAS1 protects chondrocytes from IL-1β-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis

Journal of Orthopaedic Surgery and Research, 2023
Background Increasing evidence suggested that long non-coding RNAs (lncRNAs) played vital roles in osteoarthritis (OA) progression. In this study, we aimed to reveal the protective roles of lncRNA ZFAS1 in osteoarthritis (OA) and further investigated its
Jicheng Han, Zongjian Luo, Yifei Wang, Yantao Liang   +3 more
doaj   +1 more source

Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence [PDF]

, 2015
Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined.
Arakaki, Naomi, Fernandez Espinosa, Damian Dario, Garcia, Carolina Paola, Martinetto, Horacio Enrique, Miriuka, Santiago Gabriel, Roisman, Alejandro, Romorini, Leonardo, Scassa, Maria Elida, Sevlever, Gustavo Emilio, Slavutsky, Irma Rosa, Videla Richardson, Guillermo Agustín   +10 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A retrospective study of 3D-printed custom titanium prostheses for reconstruction of bone defects after resection of pelvic tumors: technical points and early results

BMC Surgery
Background With the development of limb salvage technology for pelvic malignant tumor, 3D-printed custom prosthesis has become a main way to reconstruct pelvis after resection of pelvic malignant tumor.
Tiying Wang, Xiang Ma, Ya Zhang, Jing Li, Lei Han, Zia-ul-Haq Nabil, Yan Liu, Linhao Cai, Weiquan Wang, Zhou Huang, Zuozhang Yang   +10 more
doaj   +1 more source

Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients

BMC Cancer, 2018
Background Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims of this study were to investigate the immune landscape of neuroblastoma and to evaluate the in vivo immunogenicity of the NY-ESO-1 ...
Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli, Roberto Luksch   +11 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C., Baltimore, David, Hasserjian, Robert P., Pear, Warren S., Scott, Martin L., Sklar, Jeffrey, Soffer, Benny   +6 more
core