Results 81 to 90 of about 1,941,754 (312)

Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients

BMC Cancer, 2018
Background Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims of this study were to investigate the immune landscape of neuroblastoma and to evaluate the in vivo immunogenicity of the NY-ESO-1 ...
Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli, Roberto Luksch   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors

, 2011
© Springer Science+Business Media B.V. 2011Bone is a major target for metastases in the most frequent solid tumors, which result in severe complications and are a major cause of pain. A bone metastasis gene expression signature was identified using human
Sandra Casimiro, Portela, José, António F. Francisco, Costa, Luis, Correia, Lurdes, Afonso Fernandes, Francisco, António F., Lurdes Correia, Vaz Luis, Ines, António G. Gouveia, Pinto, Andreia, Gouveia, António G., Pires, Ricardo, José Portela, Luis Costa, Casimiro, Sandra, Andreia Pinto, Inês Luis, Fernandes, Afonso, Ricardo Pires   +19 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC

Frontiers in Immunology
BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly to its poor ...
Long Chen, Houzhi Yang, Xianfu Wei, Xianfu Wei, Jianchao Liu, Xiuxin Han, Chao Zhang, Yongheng Liu, Yan Zhang, Yao Xu, Yiqin Li, Guowen Wang, Jinyan Feng   +12 more
doaj   +1 more source

Primary bone tumors of fibula

, 2006
Purpose: The purpose of this study was to investigate on primary bone tumors of fibula. Materials and Methods: Patients who received operative treatment from January 1993 to December 2005 for primary bone tumors of fibula were analyzed for clinical ...
신규호
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Immunotherapy-based salvage therapy in advanced soft tissue sarcoma after first-line chemotherapy: a retrospective single-center analysis with emphasis on undifferentiated pleomorphic sarcoma

Frontiers in Immunology
IntroductionSoft tissue sarcomas (STS) are rare mesenchymal malignancies with limited treatment options in advanced stages. Anthracycline-based chemotherapy remains the standard of care but yields modest outcomes with significant toxicity, underscoring ...
Zhichao Liao, Zhichao Liao, Zhichao Liao, Junbo Huang, Junbo Huang, Junbo Huang, Haotian Liu, Haotian Liu, Haotian Liu, Chao Zhang, Chao Zhang, Chao Zhang, Ting Li, Ting Li, Ting Li, Hongyu Wang, Hongyu Wang, Hongyu Wang, Yuanxin Liu, Yuanxin Liu, Yuanxin Liu, Sijia Ren, Sijia Ren, Sijia Ren, Zhiwu Ren, Zhiwu Ren, Zhiwu Ren, Haixiao Wu, Haixiao Wu, Haixiao Wu, Ruwei Xing, Ruwei Xing, Ruwei Xing, Sheng Teng, Sheng Teng, Sheng Teng, Jun Zhao, Jun Zhao, Jun Zhao, Wanyi Xiao, Wanyi Xiao, Wanyi Xiao, Gengpu Zhang, Gengpu Zhang, Gengpu Zhang, Yun Yang, Yun Yang, Yun Yang, Jilong Yang, Jilong Yang, Jilong Yang   +50 more
doaj   +1 more source