Results 81 to 90 of about 141,702 (274)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Evolving sensitivity balances Boolean Networks. [PDF]

PLoS ONE, 2012
We investigate the sensitivity of Boolean Networks (BNs) to mutations. We are interested in Boolean Networks as a model of Gene Regulatory Networks (GRNs). We adopt Ribeiro and Kauffman's Ergodic Set and use it to study the long term dynamics of a BN. We
Jamie X Luo, Matthew S Turner
doaj   +1 more source

Excitability in autonomous Boolean networks

, 2012
We demonstrate theoretically and experimentally that excitable systems can be built with autonomous Boolean networks. Their experimental implementation is realized with asynchronous logic gates on a reconfigurabe chip.
Arthur J., Bellido-Diaz M. J., Damien Rontani, Daniel J. Gauthier, David P. Rosin, Eckehard Schöll, FitzHugh R., Glass L., Indiveri G., Izhikevich E. M., Jeong Y. Jung S. Liu J., Kanter I., Keener J. P., Lehnert J., Maxfield C., McCulloch W. S., Panchuk A. Rosin D. P. Hövel P. Schöll E., Schiff S. J., Vardi R.   +18 more
core   +1 more source

Contextual Random Boolean Networks

, 2003
We propose the use of Deterministic Generalized Asynchronous Random Boolean Networks [Gershenson, 2002] as models of contextual deterministic discrete dynamical systems. We show that changes in the context have drastic effects on the global properties of the same networks, namely the average number of attractors and the average percentage of states in ...
Carlos Gershenson, Jan Broekaert, Diederik Aerts   +2 more
openaire   +3 more sources

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

Advanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao, Genda Wang, Jiabao Bai, Kai Liu   +3 more
wiley   +1 more source

Boolean Game on Scale-free Networks

, 2006
Inspired by the local minority game, we propose a network Boolean game and investigate its dynamical properties on scale-free networks. The system can self-organize to a stable state with better performance than random choice game, although only the ...
Albert, Anghel, Barabási, Barabási, Bouchaud, Burgos, Burgos, Challet, Challet, Challet, Challet, Challet, Chau, Chow, Cont, de Cara, D’hulst, D’hulst, Eguíluz, Jing Ma, Johnson, Johnson, Johnson, Johnson, Kalinowski, Kim, Kullmann, Lam, Li, Li, Mantegna, Mantegna, Mantegna, Marsili, Moelbert, Motter, Paczuski, Pei-Ling Zhou, Pla, Quan, Savit, Shi-Min Cai, Slanina, Tao Zhou, Vázquez, Wang, Wang, Wen-Jie Bai, Xie, Xie, Yang, Yin, Zhou, Zhou   +53 more
core   +1 more source

Intervention in a family of Boolean networks [PDF]

Bioinformatics, 2005
AbstractMotivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied in the framework of a probabilistic Boolean network (PBN), which is a collection of Boolean networks in which the gene state vector transitions according to the rules
Ashish Choudhary, Aniruddha Datta, Michael L. Bittner, Edward R. Dougherty   +3 more
openaire   +2 more sources