Results 71 to 80 of about 643,287 (307)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

First‐ever Marburg virus disease outbreak in Equatorial Guinea and Tanzania: An imminent crisis in West and East Africa

Immunity, Inflammation and Disease, 2023
The Marburg virus, which is a member of the same virus family as the Ebola virus called Filoviridae, causes the severe infectious disease known as Marburg virus disease (MVD).
Olivier Sibomana, Emmanuel Kubwimana
doaj   +1 more source

Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019

Viruses, 2021
Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated ...
Natalia Golender, Velizar Bumbarov, Anita Kovtunenko, Dan David, Marisol Guini-Rubinstein, Asaf Sol, Martin Beer, Avi Eldar, Kerstin Wernike   +8 more
doaj   +1 more source

Increased Expressions of ADAMTS-13, Neuronal Nitric Oxide Synthase, and Neurofilament Correlate with Severity of Neuropathology in Border Disease Virus-Infected Small Ruminants

PLoS ONE, 2015
Border Disease (BD), caused by Pestivirus from the family Flaviviridae, leads to serious reproductive losses and brain anomalies such as hydranencephaly and cerebellar hypoplasia in aborted fetuses and neonatal lambs.
G. Dincel, O. Kul
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Two different epidemiological scenarios of border disease in the populations of Pyrenean chamois (Rupicapra p. pyrenaica) after the first disease outbreaks.

PLoS ONE, 2012
Since 2001 several outbreaks of a new disease associated with Border disease virus (BDV) infection have caused important declines in Pyrenean chamois (Rupicapra pyrenaica) populations in the Pyrenees.
Laura Fernández-Sirera, Oscar Cabezón, Alberto Allepuz, Rosa Rosell, Cristina Riquelme, Emmanuel Serrano, Santiago Lavín, Ignasi Marco   +7 more
doaj   +1 more source

A dynamic model of transmission and elimination of peste des petits ruminants in Ethiopia [PDF]

, 2018
Peste des petits ruminants (PPR), a devastating viral disease of sheep and goats, has been targeted by the global community for eradication within the next 15 years.
Abebe, Agnès Waret-Szkuta, Anton Camacho, Baars, Baudon, Beyene, Dean, Dirk U. Pfeiffer, Faris, François Roger, Getachew, Gubbins, Guillaume Fournié, Hammami, Hoffmann, Intisar, Jones, Kardjadj, Kihu, Kivaria, Kullback, Laike M. Yigezu, Libeau, Marashi, Mariner, Megersa, Molia, Muniraju, Mweu, Ortiz-Pelaez, Pegram, Roger, Rony, Taye, Waret-Szkuta   +34 more
core   +5 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Genetic diversity and transmission dynamics of SARS-CoV-2 in East Africa

Scientific Reports
COVID-19 is a respiratory disease caused by the SARS-CoV-2 virus, which put the entire world on hold for two years from 2020 to March 2022 before the rapid roll-out of vaccines. This virus claimed many lives, 6,331,727 deaths globally, and 172,390 people
Patricia Nabisubi, Stephen Kanyerezi, Herbert Agasi, Shahiid Kiyaga, Eva Akurut, Grace Kebirungi, Gerald Mboowa, Daudi Jjingo, Ronald Galiwango   +8 more
doaj   +1 more source

Ear tissue as a diagnostic sample for pestivirus detection in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway

Frontiers in Microbiology
IntroductionAlthough eradication programs have successfully controlled pestivirus infections in domestic livestock across Fennoscandia, serological evidence suggests that several free-ranging, semi-domesticated reindeer herds are exposed to and possibly ...
Ester Malmström, Morten Tryland, Thomas Passler, Alice Becker, Stine Bull-Aurbakken, Scott Silvis, Rachel Phillips, Shollie Falkenberg, Shollie Falkenberg   +8 more
doaj   +1 more source