Results 51 to 60 of about 3,839 (161)

Genomic and epigenomic insights into purkinje and granule cells in Alzheimer's disease‐related dementia using single‐nucleus multiome analysis

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Recent advances in single‐cell/nuclei multiome technology have enabled simultaneous profiling of gene expression and chromatin accessibility from the same nuclei, providing opportunities to interrogate the regulatory underpinnings responsible for Alzheimer's disease (AD) relevant transcriptomic and epigenomic features in a cell type‐
Feixiong Cheng, Yayan Feng, Margaret E Flanagan, Borna Bonakdarpour, Jeffrey L. Cummings   +4 more
wiley   +1 more source

Musical Museum: An Interdisciplinary Approach to Integrative Life Enrichment for Individuals with Neurocognitive Disorders and their Care Partners

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Social, emotional, and cognitive stimulation are protective factors that can slow neurocognitive disorder (NcD) progression, making them priorities for early and moderate dementia interventions. Live music programs with music appreciation content provide social‐emotional interaction, intellectual stimulation, and serve as social ...
Melanie Zhang, Jonathan Zhao, Kate Vidano, Clara Takarabe, Borna Bonakdarpour   +4 more
wiley   +1 more source

Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder

Frontiers in Psychology
IntroductionIn severe cases, an infection with the Borna Disease Virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported to be accompanied by cognitive dysfunctions, seizures, deep coma, or severe
Anna J. Torner, Bernhard T. Baune, Bernhard T. Baune, Bernhard T. Baune, Kristian Folta-Schoofs, Detlef E. Dietrich, Detlef E. Dietrich, Detlef E. Dietrich   +7 more
doaj   +1 more source

Clinical Improvisatory Music for Alzheimer's Disease Anxiety and Caregivers (CIMAC): Preliminary Behavioral and Network Modulation Findings from Ongoing Trials

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Approximately 40% of individuals with Alzheimer's disease (AD) experience anxiety (AD‐A), decreasing their quality of life and burdening caregivers. Anxiety medications can have negative side effects, prompting exploration of non‐pharmacological interventions like music.
Kate Vidano, Jordan Quinn Behn, Clara Takarabe, Borna Bonakdarpour   +3 more
wiley   +1 more source

MET‐FTD: Music‐based Empathy Training for Frontotemporal Dementia

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Behavioral variant frontotemporal dementia (bvFTD) often presents with social cognition and behavior changes out of proportion to cognitive decline. BvFTD has the highest caregiver burden of any dementia, leading to significant marital problems not infrequently ending in divorce.
Kaitlin Seibert, Elena Badillo‐Goicoechea, Grace Lee, Miles Breese, Mia Krings, Rebecca J.F. Freiman, Jeffrey Wolfe, Borna Bonakdarpour   +7 more
wiley   +1 more source

Infection of Borna disease virus in healthy animals in northern China

Asian Pacific Journal of Tropical Medicine, 2018
Borna disease virus (BDV) is a non-segmented, single negative stranded RNA virus. It is highly neurotropic, but the infection is not cytopathic to the infected cells.
Ai-xia Zhai, Ai-mei Li, Wu-qi Song, Wen-ping Kao, Jun Qian, Yu-jun Li, Qing-meng Zhang, Le-le Cui, Tong Bu, Han-xu Zhang, Feng-min Zhang   +10 more
doaj   +1 more source

COVID‐19 Vaccine Effectiveness Against Hospitalization in Older Adults, VEBIS Hospital Network, Europe, September 2024–May 2025

Influenza and Other Respiratory Viruses, Volume 19, Issue 11, November 2025.
ABSTRACT We estimated COVID‐19 vaccine effectiveness (VE) against PCR‐confirmed SARS‐CoV‐2 hospitalization in patients ≥ 60 years with severe acute respiratory infection, using a multicenter, test‐negative, case–control study across seven sites in six European countries between September 2024 and May 2025.
Madelyn Rojas‐Castro, Nuno Verdasca, Susana Monge, Laurane De Mot, Camino Trobajo‐Sanmartín, Róisín Duffy, Gergő Túri, Monika Kuliese, Ralf Duerrwald, Maria‐Louise Borg, Odette Popovici, Verónica Gomez, Zvjezdana Lovrić Makarić, Odile Launay, Diogo F. P. Marques, Francisco Pozo, Arne Witdouck, Iván Martínez‐Baz, Margaret Fitzgerald, Beatrix Oroszi, Ligita Jančorienė, Silke Buda, Ausra Dziugyte, Mihaela Lazăr, Ausenda Machado, Irena Tabain, Liem Binh Luong Nguyen, Eva Rivas Wagner, François Dufrasne, Jesús Castilla, Lisa Domegan, Viktória Velkey, Fausta Majauskaite, Carolin Hackmann, Nathalie Nicolay, Sabrina Bacci, Angela M. C. Rose, European Hospital Vaccine Effectiveness Group   +37 more
wiley   +1 more source

Understanding the Enigmatic Dance of Immune‐Mediated Viral Infections and Their Pathogenetic Mechanisms

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut, Tuba Çiğdem Oğuzoğlu   +1 more
wiley   +1 more source

Bornavirus y enfermedades neuropsiquiátricas

Acta Médica Costarricense, 2006
La enfermedad producida por el virus de la enfermedad de Borna (VEB) o Borna Disease Virus (BDV), conocida como una encefalitis fatal, se ha reportado en caballos y ovejas en Europa Central, desde hace más de dos siglos.
Xinia Barrantes-Rodríguez, Sandra Silva-de la Fuente, José A Bonilla-Vargas, Fernando I Puerto   +3 more
doaj   +2 more sources

Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats

Neuropsychiatric Disease and Treatment, 2018
Chenmeng Li,1–3,* Xiaoyan Xu,2–4,* Xiong Zhang,2–4,* Ke Cheng,2,3,* Yujie Guo,1–3 Jie Jie,1–3 Hua Guo,1–3 Yong He,1–3 Chanjuan Zhou,2,3 Siwen Gui,2,3 Xiaogang Zhong,2,3 Haiyang Wang,2–4 Peng Xie1–4 ...
Li C, Xu X, Zhang X, Cheng K, Guo Y, Jie J, Guo H, He Y, Zhou C, Gui S, Zhong X, Wang H, Xie P   +12 more
doaj