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Borna disease: virus-induced neurobehavioral disease pathogenesis
Current Opinion in Microbiology, 2001Studies of the pathogenesis of neurobehavioral diseases following Borna disease virus infections have been increasing rapidly over the past ten years. Recent major advances have included a report of vertical transmission of the virus in its natural host, the horse, and a report of isolation of a novel variant, No/98, in that same species.
Kathryn M Carbone +2 more
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Journal of Neurovirology, 2002
Borna disease virus, a negative-strand RNA virus, infects a wide variety of warm-blooded animals. Depending on the age of the host and the integrity of its immune response, infection may be asymptomatic or cause a broad spectrum of behavioral disorders.
Mady, Hornig +2 more
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Borna disease virus, a negative-strand RNA virus, infects a wide variety of warm-blooded animals. Depending on the age of the host and the integrity of its immune response, infection may be asymptomatic or cause a broad spectrum of behavioral disorders.
Mady, Hornig +2 more
openaire +2 more sources
Dementia and Borna Disease Virus
Dementia and Geriatric Cognitive Disorders, 1997Human Borna disease virus (BDV) infection has been reported to be a threat to mental health [1]. BDV is an unclassified, nonsegmented negative sense single-stranded RNA virus which naturally infects horses, cattle, cats and sheep [2, 3]. Infection causes disturbances in behavior and cognitive function [1].
T, Igata +7 more
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Borna disease virus and schizophrenia
Psychiatry Research, 1995The development of a new serological assay method to detect antibodies in human sera recognizing Borna disease virus (BDV) proteins and a clinical pilot study are presented. Psychiatric patients from a schizophrenia research clinic in Baltimore, Maryland, were examined for antibodies to BDV antigen with traditional indirect immunofluorescence assays ...
R W, Waltrip +7 more
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Comparative Immunology, Microbiology and Infectious Diseases, 1978
Abstract Borna is an ideal model for the study of the pathogenesis of slow virus diseases. Our present knowledge of the nature of the agent, the immunology, the pathogenesis, the different courses of infection and diagnosis is described. The wide host and cell spectrum of Borna virus leads one to suppose that Borna infections are more widespread ...
A, Mayr, K, Danner
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Abstract Borna is an ideal model for the study of the pathogenesis of slow virus diseases. Our present knowledge of the nature of the agent, the immunology, the pathogenesis, the different courses of infection and diagnosis is described. The wide host and cell spectrum of Borna virus leads one to suppose that Borna infections are more widespread ...
A, Mayr, K, Danner
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The immunopathogenesis of Borna disease virus infection
Frontiers in Bioscience, 2002Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo.
Lothar, Stitz +2 more
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Borna disease virus and infection in humans
Frontiers in Bioscience, 2002Borna disease virus (BDV) is a nonsegmented, negative-, single-stranded, highly neurotropic RNA virus with noncytolytic replication in the central nervous system. This virus causes neurological and behavioral disturbances primarily in horses and sheep, in addition to a variety of other vertebrate animal species and in laboratory animal models.
Kazuyoshi, Ikuta +3 more
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Borna disease virus is not sensitive to amantadine
Archives of Virology, 1997Successful inhibition of Borna disease virus (BDV) by amantadine in cultured cells and in an infected human individual has been reported [Bode et al. (1997) Lancet 349: 178-179]. We now found that infection of monkey Vero cells by laboratory strains of BDV was not influenced by amantadine under conditions that reduced the yields of influenza A virus by
Hallensleben, Wiebke +2 more
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Borna disease virus infection in cats
The Veterinary Journal, 2014Bornaviruses are known to cause neurological disorders in a number of animal species. Avian Bornavirus (ABV) causes proventricular dilatation disease (PDD) in birds and Borna disease virus (BDV) causes Borna disease in horses and sheep. BDV also causes staggering disease in cats, characterised by ataxia, behavioural changes and loss of postural ...
Jonas Johansson, Wensman +3 more
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