Results 11 to 20 of about 473,462 (215)

Increasing evidence of human infections by the neurotropic Borna disease virus 1 (BoDV-1). [PDF]

Virulence, 2023
Due to relatively rare instances of human infections by the Borna disease virus 1 (BoDV-1) and the difficulty of developing and validating a test for diagnosing it, human cases of fatal encephalitis caused by BoDV-1 have been difficult to confirm ...
Cain M, Ly H.
europepmc   +2 more sources

Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein. [PDF]

Acta Crystallogr F Struct Biol Commun, 2023
The phosphoprotein is an essential component of the replication complex in bornaviruses. Here, using X-ray crystallography, the structure of the phosphoprotein from Borna disease virus 1 is presented and its flexibility in solution is characterized.
Whitehead JD, Grimes JM, Keown JR.
europepmc   +2 more sources

Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment. [PDF]

Viruses, 2023
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment.
Teng D, Ueda K, Honda T.
europepmc   +2 more sources

No evidence of an association of multiple sclerosis (MS) with Borna disease virus 1 (BoDV-1) infections in patients within an endemic region: a retrospective pilot study. [PDF]

Infection, 2023
Background Borna disease virus 1 (BoDV-1) causes rare human infections within endemic regions in southern and eastern Germany. The infections reported to date have been linked to severe courses of encephalitis with high mortality and mostly irreversible ...
Bauswein M, Knoll G, Schmidt B, Gessner A, Hemmer B, Flaskamp M.   +5 more
europepmc   +2 more sources

Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset. [PDF]

Case Rep Psychiatry, 2023
Objective Borna disease virus 1 (BoDV-1) was proven to cause fatal encephalitis in humans in 2018. However, the effects of persistent infections remain unclear.
Matsunaga H, Fukumori A, Mori K, Morihara T, Sato S, Kitauchi K, Yanagida K, Taguchi K, Honda T, Tomonaga K.   +9 more
europepmc   +2 more sources

Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany. [PDF]

Viruses, 2023
More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid ...
Bauswein M, Eidenschink L, Knoll G, Neumann B, Angstwurm K, Zoubaa S, Riemenschneider MJ, Lampl BMJ, Pregler M, Niller HH, Jantsch J, Gessner A, Eberhardt Y, Huppertz G, Schramm T, Kühn S, Koller M, Drasch T, Ehrl Y, Banas B, Offner R, Schmidt B, Banas MC.   +22 more
europepmc   +2 more sources

Magnetic resonance imaging of human variegated squirrel bornavirus 1 (VSBV-1) encephalitis reveals diagnostic pattern indistinguishable from Borna disease virus 1 (BoDV-1) encephalitis but typical for bornaviruses. [PDF]

Emerg Microbes Infect, 2023
Human bornavirus encephalitis is an emerging disease caused by the variegated squirrel bornavirus 1 (VSBV-1) and the Borna disease virus 1 (BoDV-1).
Huhndorf M, Juhasz J, Wattjes MP, Schilling A, Schob S, Kaden I, Klaß G, Tappe D.   +7 more
europepmc   +2 more sources

Nature's defense against emerging neurodegenerative threats: Dynamic simulation, PCA, DCCM identified potential plant-based antiviral lead targeting borna disease virus nucleoprotein. [PDF]

PLoS One
The rare zoonotic Borna disease virus (BDV) causes fatal neurological disease in various animals, with a high mortality rate exceeding 90% in central Europe. However, unlike most viruses, it establishes persistent infections within the host cell nucleus,
Siddiquee NH, Hossain MI, Priya FM, Azam SB, Talukder MEK, Barua D, Malek S, Saha N, Muntaha S, Paul R, Ritu IJ, Tuly FI, Hossain A.   +12 more
europepmc   +2 more sources

Human Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease. [PDF]

Emerg Microbes Infect, 2022
Human Borna disease virus 1 (BoDV-1) encephalitis is a severe emerging disease with a very high case-fatality rate. While the clinical disease, case definitions, diagnostic algorithms and neuropathology have been described, very little is known about the
Rauch J, Steffen JF, Muntau B, Gisbrecht J, Pörtner K, Herden C, Niller HH, Bauswein M, Rubbenstroth D, Mehlhoop U, Allartz P, Tappe D.   +11 more
europepmc   +2 more sources

Word recognition memory and serum levels of Borna disease virus specific circulating immune complexes in obsessive-compulsive disorder. [PDF]

BMC Psychiatry, 2022
Background Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that persistently infects mammals including humans. BoDV-1 worldwide occurring strains display highly conserved genomes with overlapping genetic signatures between ...
Zhang Y, Alwin Prem Anand A, Bode L, Ludwig H, Emrich HM, Dietrich DE.   +5 more
europepmc   +2 more sources