Results 21 to 30 of about 5,371 (185)

Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses [PDF]

npj Viruses
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Akiko Makino, Chiaki Tanaka, Kan Fujino, Keizo Tomonaga   +3 more
doaj   +2 more sources

Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Borna disease virus 1 (BoDV-1) infection induces cognitive impairment in rodents. Emerging evidence has demonstrated that Chromatin remodeling through histone acetylation can regulate cognitive function.
Jie Jie, Xiaoyan Xu, Jinjun Xia, Zhe Tu, Yujie Guo, Chenmeng Li, Xiong Zhang, Haiyang Wang, Weihong  Song, Peng Xie   +9 more
doaj   +3 more sources

First therapeutic drug monitoring of experimental favipiravir in Borna disease virus 1 (BoDV-1) encephalitis patients reveals significant gaps in antiviral treatment: a pilot investigation [PDF]

European Journal of Medical Research
Background The Borna disease virus 1 (BoDV-1) causes a rare, but severe form of encephalitis in Germany, characterized by rapid progression, late diagnosis, and a high case fatality. Therapy is experimental and recommendations are lacking.
Michael Paal, Katharina Habler, Alice Ewert, Michael Vogeser, Leonie Grosse, Victoria Lieftüchter, Simone C. Tauber, Johannes Schiefer, Petra Allartz, Dennis Tappe, Kirsten Pörtner   +10 more
doaj   +2 more sources

Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein. [PDF]

Acta Crystallogr F Struct Biol Commun, 2023
Bornaviruses are RNA viruses with a mammalian, reptilian, and avian host range. The viruses infect neuronal cells and in rare cases cause a lethal encephalitis. The family Bornaviridae are part of the Mononegavirales order of viruses, which contain a nonsegmented viral genome.
Whitehead JD, Grimes JM, Keown JR.
europepmc   +3 more sources

Research Note: Development of a reverse transcriptase recombinase-aided amplification method for detection of Parrot Borna Virus 4 [PDF]

Poultry Science
: The Parrot Borna virus 4 (PaBV-4) is the primary causative agent of parrot developmental disorder (PDD), leading to symptoms such as bloating, undigested feed in stool, decreased appetite, diarrhea, and weight loss.
Yuhang Bai, Guixin Dong, Peng Zhang, Mengyue Dong, Jiaqian Rao, Qian Wang, Runlin Shao, Ruiheng Liu, Keyu Feng, Qingmei Xie, Xinheng Zhang   +10 more
doaj   +2 more sources

The structure of the mammalian bornavirus polymerase complex [PDF]

Nature Communications
Borna disease virus 1 (BoDV-1) is a non-segmented RNA virus with one of the smallest known RNA virus genomes. BoDV-1 replicates in the nucleus of infected cells using a virally encoded polymerase complex composed of the large protein and phosphoprotein ...
Loïc Carrique, Franziska Günl, Adrian Deng, Jonathan M. Grimes, Jeremy R. Keown   +4 more
doaj   +2 more sources

Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species [PDF]

Frontiers in Veterinary Science
Although laboratory methods have advanced, the cause of many encephalitides is still unknown. Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time ...
Madeleine de le Roi, Hannah Gerhards, Adnan Fayyad, Adnan Fayyad, Mathias Boelke, Stefanie Christine Becker, Asisa Volz, Ingo Gerhauser, Wolfgang Baumgärtner, Christina Puff   +9 more
doaj   +2 more sources

Mapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts. [PDF]

PLoS Pathogens
Borna disease virus 1 (BoDV-1) has long been recognized as a cause of fatal encephalitis in animals and was only recently identified as a zoonotic pathogen causing a similar disease in humans.
Yannik Vollmuth, Nicola Jungbäck, Przemyslaw Grochowski, Tatiana Mögele, Leonhard Stark, Niku S Zarrabi, Jürgen Schlegel, Tina Schaller, Bruno Märkl, Kaspar Matiasek, Friederike Liesche-Starnecker   +10 more
doaj   +2 more sources

Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany. [PDF]

Sci Rep, 2019
AbstractBorna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon).
Tappe D, Frank C, Offergeld R, Wagner-Wiening C, Stark K, Rubbenstroth D, Giese S, Lattwein E, Schwemmle M, Beer M, Schmidt-Chanasit J, Wilking H.   +11 more
europepmc   +7 more sources

Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido. [PDF]

J Vet Med Sci, 2021
Borna disease virus (BoDV) is a neurotropic virus that causes several infections in humans and neurological diseases in a wide range of animals worldwide. BoDV-1 has been molecularly and serologically detected in many domestic and wild animals in Japan; however, the genetic diversity of this virus and the origin of its infection are not fully ...
Sukmak M, Okamoto M, Ando T, Hagiwara K.
europepmc   +4 more sources