Results 21 to 30 of about 2,958 (113)

Antiviral treatment perspective against Borna disease virus 1 infection in major depression: a double-blind placebo-controlled randomized clinical trial [PDF]

BMC Pharmacology and Toxicology, 2020
Background Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. This called to mind previous evidence for an infectious contribution of BDV-1 to mental
Detlef E. Dietrich, Liv Bode, Carsten W. Spannhuth, Hartmut Hecker, Hanns Ludwig, Hinderk M. Emrich   +5 more
doaj   +2 more sources

BoDV-1 Infection Is Associated with Altered Prion Protein Glycoform Maturation and Reduced ETS1-MGAT5/GnTV Pathway Activity in Rat C6 Astroglial Cells [PDF]

Microorganisms
Borna disease virus 1 (BoDV-1) is a noncytolytic, neurotrophic virus that causes neurological disorders, where astrocytes contribute to neuropathology. Cellular prion protein (PrPC) is involved in pro-survival signaling and antioxidative defense.
Akikazu Sakudo, Kazuyoshi Ikuta
doaj   +2 more sources

The equine species as Trojan horse for Borna Disease Virus-1? [PDF]

Veterinary Quarterly, 2018
J.H. van der Kolk
doaj   +2 more sources

Multimodal profiling of immune responses reveals innate-adaptive immune imbalance in human bornavirus encephalitis [PDF]

Acta Neuropathologica Communications
Human bornavirus encephalitis (BVE) is a rare, emerging and fatal zoonotic disease mainly caused by the Borna disease virus 1 (BoDV-1), a non-cytolytic RNA virus.
Nicola Jungbäck, Przemyslaw Grochowski, Daniel Hieber, Moritz Dinser, Zuzanna Mielewczyk, Thomas Pfefferkorn, Birgit Muntau, Thomas Richter, Georg Rieder, Antonios Bayas, Klaus Hirschbühl, Bruno Märkl, Patrick Adam, Dennis Tappe, Friederike Liesche-Starnecker   +14 more
doaj   +2 more sources

Vaccination against Borna Disease: Overview, Vaccine Virus Characterization and Investigation of Live and Inactivated Vaccines

Viruses, 2022
(1) Background: Vaccination of horses and sheep against Borna disease (BD) was common in endemic areas of Germany in the 20th century but was abandoned in the early 1990s.
Ralf Dürrwald, Jolanta Kolodziejek, Djin-Ye Oh, Sibylle Herzog, Heinrich Liebermann, Nikolaus Osterrieder, Norbert Nowotny   +6 more
doaj   +1 more source

Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020

Emerging Infectious Diseases, 2021
Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1).
Philip Eisermann, Dennis Rubbenstroth, Daniel Cadar, Corinna Thomé-Bolduan, Petra Eggert, Alexander Schlaphof, Frank Leypoldt, Martin Stangel, Thorsten Fortwängler, Florian Hoffmann, Andreas Osterman, Sabine Zange, Hans-Helmut Niller, Klemens Angstwurm, Kirsten Pörtner, Christina Frank, Hendrik Wilking, Martin Beer, Jonas Schmidt-Chanasit, Dennis Tappe   +19 more
doaj   +1 more source

A Small Interfering RNA Cocktail Targeting the Nucleoprotein and Large Protein Genes Suppresses Borna Disease Virus Infection

Frontiers in Microbiology, 2019
Recently, Borna disease virus (BoDV-1)-related fatal encephalitis human cases have been reported, which highlights the potential of BoDV-1 to cause fatal human diseases.
Da Teng, Shunsuke Obika, Keiji Ueda, Tomoyuki Honda   +3 more
doaj   +1 more source

Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses 2021, 13, 539

Viruses, 2022
Amantadine (1-amino-adamantane) is a versatile antiviral compound which has been licensed for decades against influenza viruses. During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated.
Liv Bode, Detlef E. Dietrich, Carsten W. Spannhuth, Hanns Ludwig   +3 more
doaj   +1 more source

Rustrela Virus-Associated Encephalomyelitis (‘Staggering Disease’) in Cats from Eastern Austria, 1994–2016

Viruses, 2023
Clinical cases of ‘staggering disease’, a nonsuppurative encephalomyelitis associated with gait abnormalities in cats, have been documented for decades in Sweden. In Austria, an increased incidence was observed in the 1990s. Only recently, rustrela virus
Viktoria Weiss, Pia Weidinger, Julia Matt, Christiane Weissenbacher-Lang, Norbert Nowotny, Herbert Weissenböck   +5 more
doaj   +1 more source

Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment

Viruses, 2023
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment.
Da Teng, Keiji Ueda, Tomoyuki Honda
doaj   +1 more source