Results 31 to 40 of about 605 (152)

Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Borna disease virus 1 (BoDV-1) infection induces cognitive impairment in rodents. Emerging evidence has demonstrated that Chromatin remodeling through histone acetylation can regulate cognitive function.
Jie Jie, Xiaoyan Xu, Jinjun Xia, Zhe Tu, Yujie Guo, Chenmeng Li, Xiong Zhang, Haiyang Wang, Weihong  Song, Peng Xie   +9 more
doaj   +3 more sources

Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species [PDF]

Frontiers in Veterinary Science
Although laboratory methods have advanced, the cause of many encephalitides is still unknown. Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time ...
Madeleine de le Roi, Hannah Gerhards, Adnan Fayyad, Adnan Fayyad, Mathias Boelke, Stefanie Christine Becker, Asisa Volz, Ingo Gerhauser, Wolfgang Baumgärtner, Christina Puff   +9 more
doaj   +2 more sources

First isolation, in-vivo and genomic characterization of zoonotic variegated squirrel Bornavirus 1 (VSBV-1) isolates [PDF]

Emerging Microbes and Infections, 2020
The variegated squirrel bornavirus 1 (VSBV-1), a member of the family Bornaviridae, was discovered in 2015 in a series of lethal human infections. Screening approaches revealed kept exotic squirrels as the putative source of infection.Infectious virus ...
Kore Schlottau, Daniel Nobach, Christiane Herden, Stefan Finke, Martin Beer, Donata Hoffmann   +5 more
doaj   +3 more sources

Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System. [PDF]

Int J Mol Sci
Borna disease virus (BoDV-1) is a bornavirus that infects the central nervous systems of various animal species, including humans, and causes fatal encephalitis.
Sasaki S, Ogawa H, Katoh H, Honda T.
europepmc   +3 more sources

Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses. [PDF]

Microbiol Immunol
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Wu MC, Kanda T, Komorizono R, Sakai M, Leacy A, Susta L, Makino A, Tomonaga K.   +7 more
europepmc   +2 more sources

Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1

Viruses, 2022
Borna disease virus 1 (BoDV-1) is a neurotropic RNA virus belonging to the family Bornaviridae within the order Mononegavirales. Whereas BoDV-1 causes neurological and behavioral disorders, called Borna disease (BD), in a wide range of mammals, its ...
Takehiro Kanda, Keizo Tomonaga
doaj   +1 more source

Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report

BMC Infectious Diseases, 2021
Background The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany.
Dennis Tappe, Kirsten Pörtner, Christina Frank, Hendrik Wilking, Arnt Ebinger, Christiane Herden, Christoph Schulze, Birgit Muntau, Petra Eggert, Petra Allartz, Gerlind Schuldt, Jonas Schmidt-Chanasit, Martin Beer, Dennis Rubbenstroth   +13 more
doaj   +1 more source

Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein

Acta Crystallographica Section F, Volume 79, Issue 3, Page 51-60, March 2023., 2023
The phosphoprotein is an essential component of the replication complex in bornaviruses. Here, using X‐ray crystallography, the structure of the phosphoprotein from Borna disease virus 1 is presented and its flexibility in solution is characterized.Bornaviruses are RNA viruses with a mammalian, reptilian, and avian host range.
Jack D. Whitehead, Jonathan M. Grimes, Jeremy R. Keown   +2 more
wiley   +1 more source

Borna disease outbreak with high mortality in an alpaca herd in a previously unreported endemic area in Germany [PDF]

, 2020
Borna disease virus 1 (BoDV‐1) is the causative agent of Borna disease, an often fatal neurologic condition of domestic mammals, including New World camelids, in endemic areas in Central Europe.
Beer, Martin, Ebinger, Arnt, Forth, Leonie, Fürstenau, Jenny, Große, Reinhard, Hoffmann, Bernd, Höper, Dirk, Klose, Kristin, Mertsch, Tanja, Mundhenk, Lars, Müller, Kerstin-Elisabeth, Richter, Madita T., Rubbenstroth, Dennis, Schlottau, Kore, Schulze, Vanessa, Tappe, Dennis, Ulrich, Rainer   +16 more
core   +1 more source

Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity [PDF]

International Journal of Molecular Sciences, 2019
Mammalian Bornavirus (BoDV-1) typically causes a fatal neurologic disorder in horses and sheep, and was recently shown to cause fatal encephalitis in humans with and without transplant reception. It has been suggested that BoDV-1 enters the central nervous system (CNS) via the olfactory pathway.
Alexandra Kupke, Sabrina Becker, Konstantin Wewetzer, Barbara Ahlemeyer, Markus Eickmann, Christiane Herden   +5 more
openaire   +2 more sources