Results 11 to 20 of about 311 (94)

Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses. [PDF]

Microbiol Immunol
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Wu MC, Kanda T, Komorizono R, Sakai M, Leacy A, Susta L, Makino A, Tomonaga K.   +7 more
europepmc   +2 more sources

Molecular epidemiology of human Borna disease virus 1 infection revisited

Emerging Microbes and Infections, 2022
Borna disease virus 1 (BoDV-1) strains attracted public interest by recently reported rare fatal encephalitis cases in Germany. Previously, human BoDV-1 infection was suggested to contribute to psychiatric diseases.
Liv Bode, Yujie Guo, Peng Xie
doaj   +3 more sources

Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder. [PDF]

Front Psychol
IntroductionIn severe cases, an infection with the Borna Disease Virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported to be accompanied by cognitive dysfunctions, seizures, deep coma, or severe
Torner AJ, Baune BT, Folta-Schoofs K, Dietrich DE.   +3 more
europepmc   +2 more sources

BoDV-1 Infection Is Associated with Altered Prion Protein Glycoform Maturation and Reduced ETS1-MGAT5/GnTV Pathway Activity in Rat C6 Astroglial Cells. [PDF]

Microorganisms
Borna disease virus 1 (BoDV-1) is a noncytolytic, neurotrophic virus that causes neurological disorders, where astrocytes contribute to neuropathology. Cellular prion protein (PrPC) is involved in pro-survival signaling and antioxidative defense.
Sakudo A, Ikuta K.
europepmc   +2 more sources

Increasing evidence of human infections by the neurotropic Borna disease virus 1 (BoDV-1). [PDF]

Virulence, 2023
Cain M, Ly H.
europepmc   +2 more sources

Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses. [PDF]

Npj Viruses
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Makino A, Tanaka C, Fujino K, Tomonaga K.   +3 more
europepmc   +2 more sources

Long-Term Survival of Borna Disease Virus 1 (BoDV-1)-Encephalitis: An Exceptional Case with Valuable Insights for Pathophysiology and Disease Management. [PDF]

Infect Dis Ther
Introduction Borna disease virus 1 (BoDV-1) encephalitis has a (sub)acute and mostly fatal course. Initial flu-like symptoms are typically followed by rapid progressive panencephalitis and death within weeks. No curative therapy exists so far. We present
Grabova D, Wilkens I, Klein M, Heck S, Ruf V, Roeber S, Schmutzer-Sondergeld M, Brendel M, Forbrig R, Klauss H, Katzdobler S, Höglinger GU, Dimitriadis K, Straube A, Bauswein M, Kinzig M, Sörgel F, Tappe D, Masouris I, Schöberl F.   +19 more
europepmc   +2 more sources

Multimodal profiling of immune responses reveals innate-adaptive immune imbalance in human bornavirus encephalitis. [PDF]

Acta Neuropathol Commun
Human bornavirus encephalitis (BVE) is a rare, emerging and fatal zoonotic disease mainly caused by the Borna disease virus 1 (BoDV-1), a non-cytolytic RNA virus.
Jungbäck N, Grochowski P, Hieber D, Dinser M, Mielewczyk Z, Pfefferkorn T, Muntau B, Richter T, Rieder G, Bayas A, Hirschbühl K, Märkl B, Adam P, Tappe D, Liesche-Starnecker F.   +14 more
europepmc   +2 more sources

Spillover infections by rustrela virus, borna disease virus 1 and tick-borne encephalitis virus revealed by retrospective screening of mammalian encephalitis of unknown origin. [PDF]

BMC Vet Res
Background Cross-species transmission of several viral neuropathogens may lead to fatal disease in incidental hosts. The newly discovered rustrela virus (RusV) as well as Borna disease virus 1 (BoDV-1), tick-borne encephalitis virus (TBEV), and highly ...
Voss A, Günther A, Geit O, Puget C, Pauly A, Stiasny K, Schlottau K, Beer M, Gruber AD, Breithaupt A, Rubbenstroth D, Mundhenk L.   +11 more
europepmc   +2 more sources

Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection. [PDF]

Emerg Microbes Infect
Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and ...
Vollmuth Y, Jungbäck N, Mögele T, Schmidt-Graf F, Wunderlich S, Schimmel M, Rothe C, Stark L, Schlegel J, Rieder G, Richter T, Schaller T, Tappe D, Märkl B, Matiasek K, Liesche-Starnecker F.   +15 more
europepmc   +2 more sources