Recent Advancements in the Diversification and Applications of Boron-Containing Compounds in Medicinal Chemistry [PDF]
PharmaceuticalsBoron-containing compounds have made a significant impact on the field of medicinal chemistry since the discovery of Bortezomib (Velcade®), a dipeptide boronic acid approved by the FDA in 2003 for the treatment of multiple myeloma.
Marielle B. Frooman +7 more
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Boron-containing compounds in Dentistry: a narrative review. [PDF]
Rom J Morphol Embryol, 2022 Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, from cariostatic activity to anti-inflammatory and antifungal activity, paving the way for other new research ...
Mitruţ I +10 more
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Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome [PDF]
Medicina, 2023 The microbiota–gut–brain axis has garnered increasing attention in recent years for its role in various health conditions, including neuroinflammatory disorders like complex regional pain syndrome (CRPS). CRPS is a debilitating condition characterized by
Cristina Elena Biţă +11 more
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Recent developments in the medicinal chemistry of single boron atom-containing compounds
Acta Pharmaceutica Sinica B, 2021 Various boron-containing drugs have been approved for clinical use over the past two decades, and more are currently in clinical trials. The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;
Shu Song +7 more
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Synthesis of biologically active boron-containing compounds. [PDF]
Medchemcomm, 2018 A review focused on the synthetic methods of bioactive boron-containing compounds.
Yang F, Zhu M, Zhang J, Zhou H.
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Assessment of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial [PDF]
Trials, 2020 Objectives In this study, we investigate the effect of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19. Trial design The current study is a single-center, randomized, double-blind, placebo-
Helda Tutunchi +7 more
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Boron’s Double Edge—Antibiotics, Toxins, and the Fine Line Between Them [PDF]
MoleculesBoron is a chemically distinctive bioelement whose electron-deficient structure enables reversible coordination with oxygen-rich functional groups such as diols and hydroxyls.
Valery M. Dembitsky +3 more
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An automated positive selection screen in yeast provides support for boron-containing compounds as inhibitors of SARS-CoV-2 main protease [PDF]
Microbiology SpectrumThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to cause severe disease and deaths in many parts of the world, despite massive vaccination efforts. Antiviral drugs to curb an ongoing infection remain a priority. The virus-
Sunniva Sigurdardóttir +7 more
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THE INFLUENCE OF BORON-CONTAINING COMPOUNDS ON CARDIOVASCULAR HEALTH
Arta Medica, 2020 Objectives. Boron is a biological trace element which can be find in different natural compounds, but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans.
Maria-Victoria Racu +2 more
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Boron in Diet and Medicine: Mechanisms of Delivery and Detection [PDF]
PharmaceuticalsBoron is a trace element with multifaceted chemical and biological properties that underpin its emerging relevance in human health and medicinal chemistry.
Dorota Bartusik-Aebisher +4 more
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