Recent Advancements in the Diversification and Applications of Boron-Containing Compounds in Medicinal Chemistry [PDF]
PharmaceuticalsBoron-containing compounds have made a significant impact on the field of medicinal chemistry since the discovery of Bortezomib (Velcade®), a dipeptide boronic acid approved by the FDA in 2003 for the treatment of multiple myeloma.
Marielle B. Frooman +7 more
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Recent developments in the medicinal chemistry of single boron atom-containing compounds
Acta Pharmaceutica Sinica B, 2021 Various boron-containing drugs have been approved for clinical use over the past two decades, and more are currently in clinical trials. The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;
Shu Song +7 more
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Boron-containing compounds in Dentistry: a narrative review. [PDF]
Rom J Morphol Embryol, 2022 Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, from cariostatic
Mitruţ I +10 more
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Preclinical and histological study of boron-containing compounds hydrogels on experimental model of periodontal disease. [PDF]
Rom J Morphol Embryol, 2021 Periodontitis is a disease that affects a wide group of people, and there has been an increased interest in the research of finding useful materials that help reduce inflammation and the further loss of tissue.
Mitruţ I +7 more
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Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model. [PDF]
Turk J Biol, 2020 Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in ...
Ozansoy M +5 more
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Effects of Boron-Containing Compounds on Liposoluble Hormone Functions
Inorganics, 2023 Boron-containing compounds (BCC), particularly boronic acids and derivatives, are being increasingly tested as diagnostic and therapeutic agents. Some effects of BCC involve phenomena linked to the action of steroid or thyroid hormones; among these, are ...
Elizabeth Estevez-Fregoso +6 more
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Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome [PDF]
Medicina, 2023 The microbiota–gut–brain axis has garnered increasing attention in recent years for its role in various health conditions, including neuroinflammatory disorders like complex regional pain syndrome (CRPS). CRPS is a debilitating condition characterized by
Cristina Elena Biţă +11 more
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Фармация и фармакология (Пятигорск)The aim. In this review, information obtained through a comprehensive scan of scientific resources on recent developments in the field of health regarding boric acids and BCCs is brought together, and current and future perspectives are presented ...
O. Yunusoglu +6 more
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Assessment of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial [PDF]
Trials, 2020 Objectives In this study, we investigate the effect of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19. Trial design The current study is a single-center, randomized, double-blind, placebo-
Helda Tutunchi +7 more
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Boron’s Double Edge—Antibiotics, Toxins, and the Fine Line Between Them [PDF]
MoleculesBoron is a chemically distinctive bioelement whose electron-deficient structure enables reversible coordination with oxygen-rich functional groups such as diols and hydroxyls.
Valery M. Dembitsky +3 more
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