Results 1 to 10 of about 125,455 (211)

Recent developments in the medicinal chemistry of single boron atom-containing compounds [PDF]

Acta Pharmaceutica Sinica B, 2021
Various boron-containing drugs have been approved for clinical use over the past two decades, and more are currently in clinical trials. The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;
Shu Song, Ping Gao, Lin Sun, Dongwei Kang, Jacob Kongsted, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu   +7 more
doaj   +4 more sources

The Influence of Boron on the Structure and Properties of Hybrid Compounds Containing Zirconium and Phosphorus

Gels, 2022
In the present work, novel organic–inorganic hybrid materials containing boron, zirconium, and phosphorus were synthesized at different molar ratios, using the sol–gel method, starting from zirconyl chloride hexa-hydrate, triethyl borate, and phenyl ...
Petru Merghes, Gheorghe Ilia, Iosif Hulka, Vlad Chiriac, Narcis Varan, Vasile Simulescu   +5 more
doaj   +2 more sources

THE INFLUENCE OF BORON-CONTAINING COMPOUNDS ON CARDIOVASCULAR HEALTH [PDF]

Arta Medica, 2020
Objectives. Boron is a biological trace element which can be find in different natural compounds, but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans.
Maria-Victoria Racu, Ion Romulus Scorei, Iurie Pînzaru   +2 more
doaj   +2 more sources

Protection-Free Strategy for the Synthesis of Boro-Depsipeptides in Aqueous Media under Microwave-Assisted Conditions

Molecules, 2022
In this report, 19 boron-containing depsipeptides were synthesized via microwave-assisted Passerini three-component reaction (P-3CR) in an aqueous environment.
Shuo-Bei Qiu, Pei-Yao Liu, Bo-Cheng Wang, Pin-Rui Chen, Jing-Han Xiao, Ting-Yu Hsu, Kuan-Lin Pan, Zhi-Yin Lai, Yi-Wei Chen, Ying-Chuan Chen, Jen-Kun Chen, Po-Shen Pan   +11 more
doaj   +1 more source

Boron Chemistry for Medical Applications

Molecules, 2020
Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs.
Fayaz Ali, Narayan S Hosmane, Yinghuai Zhu   +2 more
doaj   +1 more source

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective

Molecules, 2022
A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with ...
Bhaskar C. Das, Nitesh K. Nandwana, Sasmita Das, Varsha Nandwana, Mohammed Adil Shareef, Yogarupa Das, Mariko Saito, Louis M. Weiss, Frankis Almaguel, Narayan S. Hosmane, Todd Evans   +10 more
doaj   +1 more source

Development of AMBER Parameters for Molecular Simulations of Selected Boron-Based Covalent Ligands

Molecules, 2023
Boron containing compounds (BCCs) aroused increasing interest in the scientific community due to their wide application as drugs in various fields. In order to design new compounds hopefully endowed with pharmacological activity and also investigate ...
Maria Assunta Chiacchio, Laura Legnani, Enrico Mario Alessandro Fassi, Gabriella Roda, Giovanni Grazioso   +4 more
doaj   +1 more source

Interaction of the anion [2-B₁₀H₉O(CH₂)₄O]− with secondary amines

Тонкие химические технологии, 2022
Objectives. One of the most promising methods of treating malignant tumors is 10B-neutron capture therapy. While compounds based on cluster boron anions [BnHn]2− (n = 10, 12) are often used as boron-containing agents due to the very high specific ...
E. Yu. Matveev, S. S. Novikov, V. Ya. Levitskaya, A. I. Nichugovskiy, I. E. Sokolov, K. Yu. Zhizhin, N. T. Kuznetsov   +6 more
doaj   +1 more source

Combining Two Types of Boron in One Molecule (To the 60th Anniversary of the First Synthesis of Carborane)

Chemistry, 2023
This review is an attempt to bring together the data from the literature on the synthesis and properties of icosahedral carborane derivatives, in which exo-polyhedral three- and four-coordinated boron substituents are attached directly to the carborane ...
Igor B. Sivaev
doaj   +1 more source

Boron Applications in Prevention, Diagnosis and Therapy for High Global Burden Diseases

Inorganics, 2023
The role of boron-containing compounds (BCCs) in medicine is growing [...]
Marvin A. Soriano-Ursúa
doaj   +1 more source