Results 1 to 10 of about 7,957 (160)

Synthesis and Anti-Tumor Evaluation of Carboranyl BMS-202 Analogues—A Case of Carborane Not as Phenyl Ring Mimetic [PDF]

Molecules
Carborane is considered a three-dimensional mimetic of phenyl rings in medicinal chemistry. BMS-202 is a potent PD-L1 inhibitor that can block the PD-L1/PD-1 interaction and restore the immune response to cancer cells.
Changxian Yuan, Chaofan Li, Chenyang Ma, Yuzhe Lin, Linyuan Wang, Guanxiang Hao, Yirong Zhang, Hongjing Li, Yuan Li, Yu Zhao, Nan Sun, Tiezheng Chen, Zhiguang Zhang, Dengfeng Cheng, Sinan Wang   +14 more
doaj   +2 more sources

Crystal structure of 1-butyl-2,3-dimethylimidazolium dicarba-7,8-nido-undecaborate [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title molecular salt, C9H17N2+·C2H12B9−, the carborane cage has a bridging B—H—B bond on the open B3C2 face. The butyl side chain of the cation adopts an extended conformation [C—C—C—C = 179.6 (1)°].
M. J. Klemes, L. Soderstrom, J. L. Hunting, A. S. Larsen   +3 more
doaj   +3 more sources

Charge-Compensated Derivatives of Nido-Carborane

Inorganics, 2023
This review summarizes data on the main types of charge-compensated nido-carborane derivatives. Compared with organic analogs, onium derivatives of nido-carborane have increased stability due to the stabilizing electron-donor action of the boron cage ...
Marina Yu Stogniy, Sergey A Anufriev, Igor B Sivaev   +2 more
exaly   +3 more sources

Enhancement of Aggregation-Induced Emission by Introducing Multiple o-Carborane Substitutions into Triphenylamine

Molecules, 2017
The enhancement of aggregation-induced emission (AIE) is presented on the basis of the strategy for improving solid-state luminescence by employing multiple o-carborane substituents.
Kyoya Uemura, Masayuki Gon, Kazuo Tanaka   +2 more
exaly   +3 more sources

Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy [PDF]

Nanomaterials
Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues.
Zhangali A. Bekbol, Kairat A. Izbasar, Alexander Zaboronok, Lana I. Lissovskaya, Haolan Yang, Yuriy Pihosh, Eiichi Ishikawa, Rafael I. Shakirzyanov, Ilya V. Korolkov   +8 more
doaj   +2 more sources

Structure-Activity Relationships of closo- and nido-Carborane Erlotinib Analogs: Lipophilicity as a Key Modulator of Anti-Glioma Activity [PDF]

Pharmaceuticals
Background/Objectives: To enhance the anti-glioma activity of erlotinib, we previously developed a series of carborane-based analogs exploiting the concept of three-dimensional bioisosterism.
Belén Dávila, Pablo Vignolo, Martina Silvarrey, Andrés Benítez, Juliana González Schmidt, Carmela de Arteaga Guidotti, María Fernanda García, Hugo Cerecetto, Marcos Couto   +8 more
doaj   +2 more sources

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Molecular Therapy: Oncolytics, 2022
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery.
Yu Chen, Fukuan Du, Liyao Tang, Jinrun Xu, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Qinglian Wen, Chi Hin Cho, Zhangang Xiao   +10 more
doaj   +1 more source

Synthesis, Crystal Structure, and Some Transformations of 9,12-Dichloro-ortho-Carborane

Crystals, 2022
Reaction of ortho-carborane with anhydrous AlCl3 in chloroform results in a mixture of 9-chloro, 9,12-dichloro, and 8,9,12-trichloro derivatives with 9,12-dichloro-ortho-carborane being the main product. Molecular crystal structure of 9,12-dichloro-ortho-
Sergey A. Anufriev, Sergey V. Timofeev, Olga B. Zhidkova, Kyrill Yu. Suponitsky, Igor B. Sivaev   +4 more
doaj   +1 more source

Exploiting Blood Transport Proteins as Carborane Supramolecular Vehicles for Boron Neutron Capture Therapy

Nanomaterials, 2023
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio, Edoardo Jun Mattioli, Francesco Zerbetto, Matteo Calvaresi   +3 more
doaj   +1 more source

Conformation-Dependent Electron Donation of Nido-Carborane Substituents and Its Influence on Phosphorescence of Tris(2,2′-bipyridyl)ruthenium(II) Complex

Crystals, 2022
In this work, we report the synthesis of the nido-carborane-substituted ruthenium complexes and the substituent effects of nido-carboranes on the optical properties.
Kyoya Uemura, Kazuo Tanaka, Yoshiki Chujo   +2 more
doaj   +1 more source