Results 1 to 10 of about 765 (180)

Iridium(III)-catalyzed remote B(9)−H alkylation of o-carboranes with nitrile template [PDF]

Nature Communications
Carboranes, unique three-dimensional analogs of benzene, have attracted considerable attention owing to their potential in medicine, catalysis, and materials science. Consequently, the introduction of functional groups into carborane clusters has emerged
Kyungsup Lee, Jiwon Kim, Donghun Hwang, Bora Yang, Dayeon Kang, Dongwook Kim, Mu-Hyun Baik, Phil Ho Lee   +7 more
doaj   +2 more sources

Site- and enantioselective B−H functionalization of carboranes [PDF]

Nature Communications
Functionalization of carboranes, icosahedral boron−carbon molecular clusters, is of great interest as they have wide applications in medicinal and materials chemistry.
Kyungsup Lee, Gisela A. González-Montiel, Hyeonsik Eom, Tae Hyeon Kim, Hee Chan Noh, Abdikani Omar Farah, Henry R. Wise, Dongwook Kim, Paul Ha-Yeon Cheong, Phil Ho Lee   +9 more
doaj   +2 more sources

Structure-Activity Relationships of closo- and nido-Carborane Erlotinib Analogs: Lipophilicity as a Key Modulator of Anti-Glioma Activity [PDF]

Pharmaceuticals
Background/Objectives: To enhance the anti-glioma activity of erlotinib, we previously developed a series of carborane-based analogs exploiting the concept of three-dimensional bioisosterism.
Belén Dávila, Pablo Vignolo, Martina Silvarrey, Andrés Benítez, Juliana González Schmidt, Carmela de Arteaga Guidotti, María Fernanda García, Hugo Cerecetto, Marcos Couto   +8 more
doaj   +2 more sources

Optically induced charge-transfer in donor-acceptor-substituted p- and m- C2B10H12 carboranes [PDF]

Nature Communications
Icosahedral carboranes, C2B10H12, have long been considered to be aromatic but the extent of conjugation between these clusters and their substituents is still being debated. m- and p-Carboranes are compared with m- and p-phenylenes as conjugated bridges
Lin Wu, Marco Holzapfel, Alexander Schmiedel, Fuwei Peng, Michael Moos, Paul Mentzel, Junqing Shi, Thomas Neubert, Rüdiger Bertermann, Maik Finze, Mark A. Fox, Christoph Lambert, Lei Ji   +12 more
doaj   +2 more sources

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Molecular Therapy: Oncolytics, 2022
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery.
Yu Chen, Fukuan Du, Liyao Tang, Jinrun Xu, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Qinglian Wen, Chi Hin Cho, Zhangang Xiao   +10 more
doaj   +1 more source

Exploiting Blood Transport Proteins as Carborane Supramolecular Vehicles for Boron Neutron Capture Therapy

Nanomaterials, 2023
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio, Edoardo Jun Mattioli, Francesco Zerbetto, Matteo Calvaresi   +3 more
doaj   +1 more source

Comprehensive exploration of chemical space using trisubstituted carboranes

Scientific Reports, 2021
A total of 42 trisubstituted carboranes categorised into five scaffolds were systematically designed and synthesized by exploiting the different reactivities of the twelve vertices of o-, m-, and p-carboranes to cover all directions in chemical space ...
Yasunobu Asawa, Saki Hatsuzawa, Atsushi Yoshimori, Kentaro Yamada, Akira Katoh, Hiroyuki Kouji, Hiroyuki Nakamura   +6 more
doaj   +1 more source

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

Pharmaceuticals, 2022
In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes.
Katia Messner, Billy Vuong, Geoffrey K. Tranmer   +2 more
doaj   +1 more source

Effect of Nature of Substituents on Coordination Properties of Mono- and Disubstituted Derivatives of Boron Cluster Anions [B_nH_n]^2– (n = 10, 12) and Carboranes with exo-Polyhedral B–X Bonds (X = N, O, S, Hal)

Inorganics, 2022
This review systematizes data on the coordination ability of mono- and disubstituted derivatives of boron cluster anions and carboranes in complexation with transition metals.
Evgenii Yu. Matveev, Varvara V. Avdeeva, Konstantin Yu. Zhizhin, Elena A. Malinina, Nikolay T. Kuznetsov   +4 more
doaj   +1 more source

DFT Surface Infers Ten-Vertex Cationic Carboranes from the Corresponding Neutral closo Ten-Vertex Family: The Computed Background Confirming Their Experimental Availability

Molecules, 2023
Modern computational protocols based on the density functional theory (DFT) infer that polyhedral closo ten-vertex carboranes are key starting stationary states in obtaining ten-vertex cationic carboranes.
Michael L. McKee, Jan Vrána, Josef Holub, Jindřich Fanfrlík, Drahomír Hnyk   +4 more
doaj   +1 more source