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Sakai, Makoto, サカイ, マコト, 酒井, 真理   +2 more
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The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

Molecular Pharmaceutics, 2022
Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with other traditional methods.
Qi Dai, QiYao Yang, Xiaoyan Bao, Jiejian Chen, Min Han, Qichun Wei   +5 more
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Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

Medicinal Research Reviews, 2023
AbstractBoron neutron capture therapy (BNCT) is one of the most promising treatments among neutron capture therapies due to its long‐term clinical application and unequivocally obtained success during clinical trials. Boron drug and neutron play an equivalent crucial role in BNCT.
Paolo Coghi, Jinxin Li, Narayan S. Hosmane, Yinghuai Zhu   +3 more
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Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics

Medical Physics, 1999
The potential efficacy of boron neutron capture therapy (BNCT) for malignant glioma is a significant function of epithermal‐neutron beam biophysical characteristics as well as boron compound biodistribution characteristics. Monte Carlo analyses were performed to evaluate the relative significance of these factors on theoretical tumor control using a ...
Wheeler, Floyd, Nigg, David, Capala, Jacek, Watkins, Peter, Vroegindeweij, Corine, Auterinen, Iiro, Seppälä, Tiina, Bleuel, Darren   +8 more
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Neutron fluence measurements for Boron Neutron Capture Therapy (BNCT)

Physicae Proceedings, 2012
The Boron Neutron Capture Therapy (BNCT) is an internal radiotherapy, in which 10 B compounds, selectively delivered to tumor cells, capture neutrons from an external source, emitting an particle and a recoil 7 Li nucleus. These two particles present high LET and their combined range (< 10 m) is in the magnitude of the cell radius, ideally affecting ...
Sandro Guedes, Bárbara Smilgys, Julio Cesar Hadler   +2 more
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Boron neutron capture therapy (BNCT): A radiation oncology perspective

International Journal of Radiation Oncology*Biology*Physics, 1994
Boron neutron capture therapy (BNCT) offers considerable promise in the search for the ideal cancer therapy, a therapy which selectively and maximally damages malignant cells while sparing normal tissue. This bimodal treatment modality selectively concentrates a boron compound in malignant cells, and then "activates" this compound with slow neutrons ...
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Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Applied Radiation and Isotopes, 2011
The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
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Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Applied Radiation and Isotopes
Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Shotaro, Nakamura, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
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Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)

Critical Reviews in Oncology/Hematology, 2008
Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter.
Wittig A, Michel J, Moss RL, StecherRasmussen F, Arlinghaus HF, Bendel P, Mauri PL, Altieri S, Hilger R, Salvadori PA, Menichetti L, Zamenhof R, Sauerwein WA   +12 more
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