Results 161 to 170 of about 3,740,560 (195)

Overview: Boron Neutron Capture Therapy (BNCT)

The field of cancer treatment has witnessed numerous advancements over the decades, with innovative therapies continually being developed to improve patient outcomes and reduce side effects. Among these, Boron Neutron Capture Therapy (BNCT) stands out as a promising and unique approach that leverages the principles of nuclear physics and chemistry to ...
Tahir Cakir, Nina Tuncel
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Novel Carboranylporphyrins for Application in Boron Neutron Capture Therapy (BNCT) of Tumors.

ChemInform, 2005
Abstract Condensation of a new carboranylpyrrole 1 with benzaldehydes leads to β-carboranylporphyrins 2 and 3 in good yields. These new porphyrins of high boron content (32–43%) have potential as boron delivery agents for BNCT. The X-ray structures of one β-carboranylporphyrin, of a carboranylpyrrole, and of a side-product are presented.
J. Caleb Clark, Frank R. Fronczek, M. Graça H. Vicente   +2 more
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Evaluations for prompt-gamma imaging of boron and hydrogen neutron capture reactions in boron neutron capture therapy (BNCT)

, 2002
Boron neutron capture therapy (BNCT) is used for malignant brain tumours, with a tumour selective 10B-compound as a targeting agent of the radiation dose [1].
Kotiluoto, Petri, Anttila, Kai, Serén, Tom, Kekki, Tommi, Renvall, Tommi, Tiitta, Antero, Kaschuck, Yu, Trykov, L., Auterinen, Iiro   +9 more
core   +6 more sources

The filter/moderator arrangement-optimisation for the boron-neutron capture therapy (BNCT)

Radiation Protection Dosimetry, 2004
The paper presents results of the numerical modelling of the fission-converter-based epithermal neutron source designed for the boron neutron capture therapy (BNCT) facility to be located at the Polish research nuclear reactor MARIA at Swierk. The unique design of the fission converter has been proposed due to a specific geometrical surrounding of the ...
G, Tracz, L, Dabkowski, D, Dworak, K, Pytel, U, Woźnicka   +4 more
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Long-survivors of glioblatoma treated with boron neutron capture therapy (BNCT)

Applied Radiation and Isotopes, 2011
The purpose of this study was to compare the radiation dose between long-survivors and non-long-survivors in patients with glioblatoma (GBM) treated with boron neutron capture therapy (BNCT). Among 23 GBM patients treated with BNCT, there were five patients who survived more than three years after diagnosis.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
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Spectromicroscopy of boron for the optimization of boron neutron capture therapy (BNCT) for cancer

Journal of Physics D: Applied Physics, 1998
We used synchrotron spectromicroscopy to study the microscopic distribution of boron in rat brain tumour and healthy tissue in the field of boron neutron capture therapy (BNCT). The success of this experimental cancer therapy depends on the preferential uptake of in tumour cells after injection of a boron compound (in our case , or BSH).
Gilbert, B., Redondo, J., Baudat, P. A., Lorusso, G. F., Andres, R., Van Meir, E. G., Brunet, J. F., Hamou, M. F., Suda, T., Mercanti, D., Ciotti, M. T., Droubay, T. C., Tonner, B. P., Perfetti, P., Margaritondo, G., De Stasio, G.   +15 more
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SYNTHESIS AND BIOLOGICAL EVALUATION OF BORONATED NUCLEOSIDES FOR BORON NEUTRON CAPTURE THERAPY (BNCT) OF CANCER

Nucleosides, Nucleotides and Nucleic Acids, 2001
Several N-3 substituted carboranyl Thd analogs were synthesized. These agents as well as some non-boronated nucleosides were evaluated in phosphoryl transfer assays with recombinant human TK1 and TK2. For some carboranyl thymidine analogs, TK1 phosphorylation rates approached 38% that of thymidine.
W, Tjarks, J, Wang, S, Chandra, W, Ji, J, Zhuo, A J, Lunato, C, Boyer, Q, Li, E V, Usova, S, Eriksson, G H, Morrison, G Y, Cosquer   +11 more
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Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT)

Applied Radiation and Isotopes, 2014
The first BNCT trials took place in the USA in the early 1960's, yet BNCT is still far from mainstream medicine. Nonetheless, in recent years, reported results in the treatment of head and neck cancer and recurrent glioma, coupled with the progress in developing linear accelerators specifically for BNCT applications, have given some optimism to the ...
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Efficacy of boron neutron capture therapy (BNCT) for patients with oral cancer

Oral Oncology
Although BNCT is a novel therapy for head and neck cancers, its efficacy in patients with oral cancer remains unclear.Nine patients with oral cancer underwent BNCT at Southern Tohoku BNCT Research Center. We reviewed the charts and diagnostic images of these patients and analyzed their responses and adverse events associated with the therapy.All ...
Jun Miyaguchi, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Kodai Tsuchida, Takahiro Kusaka, Yu Ohashi, Iori Kusaka, Yoshihiro Takai   +8 more
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[Boron neutron capture therapy (BNCT) as cancer treatment].

Duodecim; laaketieteellinen aikakauskirja, 2011
Boron neutron capture therapy leads to a strong local radiotherapy effect. The efficacy of the method in cancer therapy requires sufficient accumulation of boron into and a fairly superficial location of the tumor. The efficacy and tolerability of this therapy has been investigated in Finland especially in locally recurring head and neck cancer.
Heikki, Joensuu, Leena, Kankaanranta, Mikko, Tenhunen, Kauko, Saarilahti   +3 more
openaire   +1 more source