Results 161 to 170 of about 3,705 (207)

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

Molecular Pharmaceutics, 2022
Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with other traditional methods.
Qi Dai, Qiyao Yang, Xiaoyan Bao
exaly   +3 more sources

Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)

Critical Reviews in Oncology/Hematology, 2008
Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter.
Wittig A, Michel J, Moss RL, StecherRasmussen F, Arlinghaus HF, Bendel P, Mauri PL, Altieri S, Hilger R, Salvadori PA, Menichetti L, Zamenhof R, Sauerwein WA   +12 more
core   +5 more sources

Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics

Medical Physics, 1999
The potential efficacy of boron neutron capture therapy (BNCT) for malignant glioma is a significant function of epithermal‐neutron beam biophysical characteristics as well as boron compound biodistribution characteristics. Monte Carlo analyses were performed to evaluate the relative significance of these factors on theoretical tumor control using a ...
F J Wheeler, David W Nigg, Jacek Capala
exaly   +3 more sources

Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)

Radiochimica Acta, 2015
Abstract Boron neutron capture therapy (BNCT) employs 10B-pharmaceuticals administered for the treatment of malignancies, and subsequently irradiated with thermal neutrons. So far, clinical established pharmaceuticals like boron phenylalanine (BPA) or sodium boron mercaptate (BSH) use imperfect (BPA) or passive (BSH) targeting for ...
Kathrin Kettenbach, Hanno Schieferstein, Gabriele Hampel   +2 more
exaly   +2 more sources

The Finnish boron neutron capture therapy (BNCT) project

VTT Symposium, 1999
Boron neutron capture therapy (BNCT) is a new, binary radiotherapy, which is being developed especially for severe brain tumours, incurable by the present means (for an overview see articles in [1]). A suitable 10B containing carrier compound is injected into the blood circulation and taken up selectively by the cancer cells.
Auterinen, Iiro
openaire   +3 more sources

Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung

International Journal of Radiation Biology, 2019
Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non-resectable, diffuse tumors in lung.
Andrea Monti Hughes, Sara J Gonzalez, Silva Bortolussi   +2 more
exaly   +2 more sources

Evaluations for prompt-gamma imaging of boron and hydrogen neutron capture reactions in boron neutron capture therapy (BNCT)

, 2002
Boron neutron capture therapy (BNCT) is used for malignant brain tumours, with a tumour selective 10B-compound as a targeting agent of the radiation dose [1]. In this project, the possibility to measure on-line distribution of the boron neutron capture vents in patient's head during a BNCT irradiation is studied.
Kotiluoto, Petri, Anttila, Kai, Serén, Tom, Kekki, Tommi, Renvall, Tommi, Tiitta, Antero, Kaschuck, Yu, Trykov, L., Auterinen, Iiro   +9 more
core   +6 more sources

Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Applied Radiation and Isotopes, 2011
The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
openaire   +2 more sources

Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Applied Radiation and Isotopes
Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Shotaro, Nakamura, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
openaire   +2 more sources

Neutron fluence measurements for Boron Neutron Capture Therapy (BNCT)

Physicae Proceedings, 2012
The Boron Neutron Capture Therapy (BNCT) is an internal radiotherapy, in which 10 B compounds, selectively delivered to tumor cells, capture neutrons from an external source, emitting an particle and a recoil 7 Li nucleus. These two particles present high LET and their combined range (< 10 m) is in the magnitude of the cell radius, ideally affecting ...
Sandro Guedes, Bárbara Smilgys, Julio Cesar Hadler   +2 more
openaire   +1 more source