Results 171 to 180 of about 5,439 (211)

Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT)

Radiological Physics and Technology, 2017
The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept
Ryoichi, Seki, Yushi, Wakisaka, Nami, Morimoto, Masaaki, Takashina, Masahiko, Koizumi, Hiroshi, Toki, Mitsuhiro, Fukuda   +6 more
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Long-survivors of glioblatoma treated with boron neutron capture therapy (BNCT)

Applied Radiation and Isotopes, 2011
The purpose of this study was to compare the radiation dose between long-survivors and non-long-survivors in patients with glioblatoma (GBM) treated with boron neutron capture therapy (BNCT). Among 23 GBM patients treated with BNCT, there were five patients who survived more than three years after diagnosis.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
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Overview: Boron Neutron Capture Therapy (BNCT)

The field of cancer treatment has witnessed numerous advancements over the decades, with innovative therapies continually being developed to improve patient outcomes and reduce side effects. Among these, Boron Neutron Capture Therapy (BNCT) stands out as a promising and unique approach that leverages the principles of nuclear physics and chemistry to ...
Tahir Cakir, Nina Tuncel
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Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Applied Radiation and Isotopes
Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Toshiko, Sakuma, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
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Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)

Radiochimica Acta, 2015
Abstract Boron neutron capture therapy (BNCT) employs 10B-pharmaceuticals administered for the treatment of malignancies, and subsequently irradiated with thermal neutrons. So far, clinical established pharmaceuticals like boron phenylalanine (BPA) or sodium boron mercaptate (BSH) use imperfect (BPA) or passive (BSH) targeting for ...
Kathrin Kettenbach, Hanno Schieferstein, Catrin Grunewald, Dorothée Iffland, Laura M. Reffert, Gabriele Hampel, Christian L. Schütz, Nicolas H. Bings, Tobias L. Ross   +8 more
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[Boron neutron capture therapy (BNCT) as cancer treatment].

Duodecim; laaketieteellinen aikakauskirja, 2011
Boron neutron capture therapy leads to a strong local radiotherapy effect. The efficacy of the method in cancer therapy requires sufficient accumulation of boron into and a fairly superficial location of the tumor. The efficacy and tolerability of this therapy has been investigated in Finland especially in locally recurring head and neck cancer.
Heikki, Joensuu, Leena, Kankaanranta, Mikko, Tenhunen, Kauko, Saarilahti   +3 more
openaire   +1 more source

Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application

Nanomedicine: Nanotechnology, Biology and Medicine, 2014
Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a (10)B-containing drug and subsequent irradiation with low energy neutrons, which bring about the decay of (10)B to (7)Li and an α particle, causing the death of the neoplastic cell.
Achilli C., Grandi S., Ciana A., Guidetti G.F., Malara A., Abbonante V., Cansolino L., Tomasi C., Balduini A., Fagnoni M., Merli D., Mustarelli P., Canobbio I., Balduini C., Minetti G.   +14 more
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Novel Carboranylporphyrins for Application in Boron Neutron Capture Therapy (BNCT) of Tumors.

ChemInform, 2005
Abstract Condensation of a new carboranylpyrrole 1 with benzaldehydes leads to β-carboranylporphyrins 2 and 3 in good yields. These new porphyrins of high boron content (32–43%) have potential as boron delivery agents for BNCT. The X-ray structures of one β-carboranylporphyrin, of a carboranylpyrrole, and of a side-product are presented.
J. Caleb Clark, Frank R. Fronczek, M. Graça H. Vicente   +2 more
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Boron neutron capture therapy (BNCT) for head and neck tumor

Toukeibu Gan, 2011
ホウ素中性子捕捉療法（Boron neutron capture therapy, 以下BNCT）は，主として悪性脳腫瘍，悪性黒色腫に対して施行されてきた。2001年に標準治療後の再発耳下腺癌に対して，BNCTが世界初の試みとして実施され，放射線治療後の再照射であったにもかかわらず，重篤な有害事象を引き起こさずに腫瘍が著しく縮小した。それ以来，頭頸部腫瘍に対するBNCTの施行例は増加しており，日本とフィンランドから，頭頸部腫瘍に対するBNCTの治療効果として，重篤な有害事象は認めず，良好な局所治療効果が得られているとの報告がされている。今後，BNCTが頭頸部腫瘍の臨床現場に対して大きな貢献をするためには，原子炉を中性子源とするBNCTでは，症例数の限界がある。その現状を打破するため ...
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The Finnish boron neutron capture therapy (BNCT) project

VTT Symposium, 1999
Boron neutron capture therapy (BNCT) is a new, binary radiotherapy, which is being developed especially for severe brain tumours, incurable by the present means (for an overview see articles in [1]). A suitable 10B containing carrier compound is injected into the blood circulation and taken up selectively by the cancer cells.
openaire   +2 more sources