Results 171 to 180 of about 3,705 (207)

Boron neutron capture therapy (BNCT): A radiation oncology perspective

International Journal of Radiation Oncology*Biology*Physics, 1994
Boron neutron capture therapy (BNCT) offers considerable promise in the search for the ideal cancer therapy, a therapy which selectively and maximally damages malignant cells while sparing normal tissue. This bimodal treatment modality selectively concentrates a boron compound in malignant cells, and then "activates" this compound with slow neutrons ...
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Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

Expert Reviews in Molecular Medicine, 2022
Abstract Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam.
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Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Applied Radiation and Isotopes
Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Toshiko, Sakuma, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
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The filter/moderator arrangement-optimisation for the boron-neutron capture therapy (BNCT)

Radiation Protection Dosimetry, 2004
The paper presents results of the numerical modelling of the fission-converter-based epithermal neutron source designed for the boron neutron capture therapy (BNCT) facility to be located at the Polish research nuclear reactor MARIA at Swierk. The unique design of the fission converter has been proposed due to a specific geometrical surrounding of the ...
G, Tracz, L, Dabkowski, D, Dworak, K, Pytel, U, Woźnicka   +4 more
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Spectromicroscopy of boron for the optimization of boron neutron capture therapy (BNCT) for cancer

Journal of Physics D: Applied Physics, 1998
We used synchrotron spectromicroscopy to study the microscopic distribution of boron in rat brain tumour and healthy tissue in the field of boron neutron capture therapy (BNCT). The success of this experimental cancer therapy depends on the preferential uptake of in tumour cells after injection of a boron compound (in our case , or BSH).
B Gilbert, J Redondo, P-A Baudat, G F Lorusso, R Andres, E G Van Meir, J-F Brunet, M-F Hamou, T Suda, Delio Mercanti, M Teresa Ciotti, T C Droubay, B P Tonner, P Perfetti, M Margaritondo, Gelsomina De Stasio   +15 more
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Novel Carboranylporphyrins for Application in Boron Neutron Capture Therapy (BNCT) of Tumors.

ChemInform, 2005
Abstract Condensation of a new carboranylpyrrole 1 with benzaldehydes leads to β-carboranylporphyrins 2 and 3 in good yields. These new porphyrins of high boron content (32–43%) have potential as boron delivery agents for BNCT. The X-ray structures of one β-carboranylporphyrin, of a carboranylpyrrole, and of a side-product are presented.
J. Caleb Clark, Frank R. Fronczek, M. Graça H. Vicente   +2 more
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Overview: Boron Neutron Capture Therapy (BNCT)

The field of cancer treatment has witnessed numerous advancements over the decades, with innovative therapies continually being developed to improve patient outcomes and reduce side effects. Among these, Boron Neutron Capture Therapy (BNCT) stands out as a promising and unique approach that leverages the principles of nuclear physics and chemistry to ...
Tahir Cakir, Nina Tuncel
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Long-survivors of glioblatoma treated with boron neutron capture therapy (BNCT)

Applied Radiation and Isotopes, 2011
The purpose of this study was to compare the radiation dose between long-survivors and non-long-survivors in patients with glioblatoma (GBM) treated with boron neutron capture therapy (BNCT). Among 23 GBM patients treated with BNCT, there were five patients who survived more than three years after diagnosis.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
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SYNTHESIS AND BIOLOGICAL EVALUATION OF BORONATED NUCLEOSIDES FOR BORON NEUTRON CAPTURE THERAPY (BNCT) OF CANCER

Nucleosides, Nucleotides and Nucleic Acids, 2001
Several N-3 substituted carboranyl Thd analogs were synthesized. These agents as well as some non-boronated nucleosides were evaluated in phosphoryl transfer assays with recombinant human TK1 and TK2. For some carboranyl thymidine analogs, TK1 phosphorylation rates approached 38% that of thymidine.
W, Tjarks, J, Wang, S, Chandra, W, Ji, J, Zhuo, A J, Lunato, C, Boyer, Q, Li, E V, Usova, S, Eriksson, G H, Morrison, G Y, Cosquer   +11 more
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[Boron neutron capture therapy (BNCT) as cancer treatment].

Duodecim; laaketieteellinen aikakauskirja, 2011
Boron neutron capture therapy leads to a strong local radiotherapy effect. The efficacy of the method in cancer therapy requires sufficient accumulation of boron into and a fairly superficial location of the tumor. The efficacy and tolerability of this therapy has been investigated in Finland especially in locally recurring head and neck cancer.
Heikki, Joensuu, Leena, Kankaanranta, Mikko, Tenhunen, Kauko, Saarilahti   +3 more
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