Results 91 to 100 of about 17,314 (245)

Dynamic covalent nanoparticle building blocks [PDF]

, 2016
The author thanks the Royal Society of Edinburgh and Scottish Government for a personal research fellowship and gratefully acknowledge the EPSRC (EP/K016342/1) and Leverhulme Trust (RPG-2015-042) for funding our work on dynamic nanomaterials.Rational and
Kay, Euan Robert
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications, 2016
Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a ...
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield   +9 more
doaj   +1 more source

SABER for life saving: dynamic peptide hydrogels as a frontier in long-acting therapeutics [PDF]

Exploration of BioMat-X
Hydrogels are among the most intensively studied biomaterials for controlled drug delivery, yet translation to routine clinical practice has been limited by rapid diffusion of small molecules and instability of biologics. In their recent report in Nature
Deepak Chaurasiya
doaj   +1 more source

Teaching the Basics of Reactive Oxygen Species and their Relevance to Cancer Biology: Mitochondrial Reactive Oxygen Species Detection, Redox Signaling, and Targeted Therapies [PDF]

, 2016
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation, tumor progression, and metastasis). Of the many cellular sources of ROS generation, the mitochondria and the NADPH oxidase family of enzymes are possibly the most ...
Bennett, Brian, Cheng, Gang, Hardy, Micael, Kalyanaraman, Balaraman, Ouari, Olivier, Zielonka, Jacek   +5 more
core   +1 more source

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

Stereodivergent Olefination of Enantioenriched Boronic Esters [PDF]

, 2017
A stereodivergent coupling reaction between vinyl halides and boronic esters is described. This coupling process proceeds without a transition‐metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl boronate complex ...
Aggarwal, Varinder K., Armstrong, Roly J., García-Ruiz, Cristina, Myers, Eddie L.   +3 more
core   +2 more sources

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Dynamic covalent assembly and disassembly of nanoparticle aggregates [PDF]

, 2016
This work was supported by the EPSRC (EP/K016342/1 and EP/J500549/1), the University of St Andrews and by a Royal Society of Edinburgh/Scottish Government Fellowship (E.R.K.).The quantitative assembly and disassembly of a new type of dynamic covalent ...
Borsley, Stefan, Kay, Euan R.
core   +1 more source

Boron beats nitrogen: strained boron–boron bonds as (molecular) proton sponges

Physical Chemistry Chemical Physics
The basicity and the hydrogen bond (HB) acceptor capability of diborane derivatives of dipyrazole 1 with a B–B bond have been studied theoretically using M06-2x and CCSD(T) methods. The proton affinities of 1b reach 1096 kJ mol−1.
Ibon Alkorta, José Elguero, M. Merced Montero-Campillo, Otilia Mó, Manuel Yáñez   +4 more
openaire   +2 more sources