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DURATION OF PASSIVE IMMUNITY TO BOTULINUM TOXIN OFFERED BY ANTITOXIN IN MICE AND RABBITS
1965Abstract : Various doses of botulinum antitoxin, types A and B, were administered to mice and rabbits by the intraperitoneal and intravenous routes. The persistence of a passive immunity to the type A toxin was determined by (1) administering challenge doses of the toxin at various times after the antitoxin and (2) determining the median lethal ratios (
James W. Crook +2 more
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Investigation of the Prolonged Recovery Time Following Botulinum Intoxication. Efficacy of Intraperitoneal versus Intravenous Injection of Botulinum Antitoxin. [PDF]
, 1973 Abstract : In order to study prolonged recovery times, mice were injected via the intramuscular route with sublethal concentrations of botulinum type A toxin. Proteolytic enzyme solutions were injected into the test site to determine if the removal of bound proteinacious toxin from neuromuscular junctions could influence paralytic recovery times ...
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In vitro assays for botulinum toxin and antitoxins.
Developments in biological standardization, 1987Clostridium botulinum produces several powerful neuroparalytic toxins which, although rare in food-poisoning instances, are generally fatal. A considerable amount of effort has therefore been made by the food industry to ensure that food treatment processes adequate to prevent growth and toxin production by Cl. botulinum.
C, Shone +6 more
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Anaphylaxis to Botulinum Antitoxin: A Systematic Review
Journal of Allergy and Clinical Immunology, 2017Edith Schussler +4 more
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Source of Botulinum Antitoxin Products Needs Clarifying
Pediatric Annals, 2010LCDR Ryan P. Fagan, CAPT Hye-Joo Kim
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Development of in vitro functional replacement assays for Botulinum toxin and antitoxin preparations
2011Botulinum neurotoxins are lethal toxins that induce prolonged muscle paralysis by blocking the release of neuronal transmitters from peripheral cholinergic nerve endings. Although highly toxic, botulinum toxins are available as licensed drugs for the treatment of a variety of medical disorders and increasingly applied for cosmetic purposes which ...
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