Results 171 to 180 of about 121,700,018 (217)
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Botulinum neurotoxin type A in facial aesthetics
Expert Opinion on Pharmacotherapy, 2007Injection of botulinum neurotoxin type A has rapidly become the most common non-surgical cosmetic procedure performed, due to its exceptional safety profile, as well as its ability to rejuvenate and enhance a number of facial areas. There are several marketed botulinum neurotoxin preparations, but products are not interchangeable as each possesses ...
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Botulinum neurotoxin type C (Clostridium botulinum)
1997Abstract Botulinum neurotoxin C (BoNT/C} is one of the seven neurotoxins produced by the anaerobic bacteria Clostridium botulinum, and are responsible for the flaccid paralysis characteristic of botulism. Its structural gene is located on the genome of bacteriophages (GenBank accession number X53751), which produce a 150 kDa protein of ...
J Herreros, J Blasi
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Patient‐reported outcomes with botulinum neurotoxin type A
Journal of Cosmetic and Laser Therapy, 2007Clinical trials establishing the efficacy of botulinum neurotoxin type A historically have included as outcomes investigator assessments and general patient global assessments of treatment. However, these outcomes are of limited value in determining the specific benefits desired by patients who seek facial rejuvenation.
Alastair, Carruthers, Jean, Carruthers
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Comparative sizes of type A and B botulinum neurotoxins
Toxicon, 1977NEUROTOXINS of Clostridiwn botulinum are synthesized as molecules of low or possibly no toxicity ; they attain their characteristically high specific toxicity when activated by culture protease(s) or by trypsin. At their highest attainable specific toxicity types A, B, E and F neurotoxins have a structural similarity : they are nicked proteins composed
B R, DasGupta, H, Sugiyama
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Botulinum neurotoxins type A and E (Clostridium botulinum)
1997Abstract Botulinum neurotoxins are structurally related protein toxins (BoNTs) produced by Clostridia in seven different serotypes: A, B, C, D, E, F, and G. BoNTs penetrate motorneurons at the neuromuscular junction and block acetylcholine release, thus causing the flaccid paralysis of botulism.
O Rossetto, R Pellizzari
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Pharmacokinetic properties of different formulations of botulinum neurotoxin type A
Movement Disorders, 2004Although the relative potency measured by the number of units per nanogram of the toxin is different for the three preparations (BOTOX = 20 U/ng; Dysport = 40 U/ng, and CS-BOT = 15.2 U/ng), the effective dose for CS-BOT is similar to that of BOTOX (Allergan, Irvine, CA).
Kai, Wohlfarth +2 more
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Separation of the components of type A botulinum neurotoxin complex by electrophoresis
Toxicon, 2003Clostridium botulinum neurotoxins (BoNTs) are the most toxic substances known. They exert potent neuroparalysis on vertebrates. C. botulinum produces seven serotypes of neurotoxin (A-G). BoNT/A, found in bacterial cultures of C. botulinum type A, is produced as a complex with a group of neurotoxin associated proteins (NAPs).
S K, Sharma, M A, Ramzan, B R, Singh
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Development of Potent Inhibitors of Botulinum Neurotoxin Type B
Journal of Medicinal Chemistry, 2003Botulinum neurotoxins are the most potent toxins known to date. They are zinc-metalloproteases able to cleave selectively an essential component of neurotransmitter exocytosis, causing the syndrome of botulism characterized by a flaccid paralysis. There is a great interest in designing antagonists of the action of these toxins.
Anne, Christine +6 more
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Clinical differences between botulinum neurotoxin type A and B
Toxicon, 2015In humans, the therapeutic use of botulinum neurotoxin A (BoNT/A) is well recognized and continuously expanding. Four BoNTs are widely available for clinical practice: three are serotype A and one is serotype B: onabotulinumtoxinA (A/Ona), abobotulinumtoxinA (A/Abo) and incobotulinumtoxinA (A/Inco), rimabotulinumtoxinB (B/Rima).
Bentivoglio, Anna Rita +4 more
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Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease*
The Journal of Peptide Research, 2004Abstract: Botulinum neurotoxin (BoNT) metalloproteases and related proteases are the most selective proteases known. X‐ray crystal structures suggest that the active sites of the native enzymes exist in catalytically incompetent forms that must be activated by substrate binding.
C, Sukonpan +5 more
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