Results 81 to 90 of about 121,700,018 (217)

Analysis of genomic differences among Clostridium botulinum type A1 strains

BMC Genomics, 2010
Background Type A1 Clostridium botulinum strains are a group of Gram-positive, spore-forming anaerobic bacteria that produce a genetically, biochemically, and biophysically indistinguishable 150 kD protein that causes botulism.
Singh Bal, Maslanka Susan E, Cai Shuowei, Raphael Brian H, Fang Ping-Ke   +4 more
doaj   +1 more source

DNA Repair Pathway Variants Are Enriched in Individuals with Biallelic AAGGG CANVAS and RFC1‐Related Disease

Movement Disorders, Volume 41, Issue 10, Page 2745-2754, October 2026.
Abstract Background Cerebellar ataxia, neuropathy and vestibular are flexia syndrome (CANVAS) and RFC1‐related disease are most commonly caused by biallelic AAGGG repeat expansions in RFC1. The high population frequency of this expansion compared to the frequency of CANVAS suggests incomplete penetrance.
Xuemin Wang, Liam G. Fearnley, Kayli C. Davies, Penny Snell, Stuart Lee, Victoria E. Jackson, Justin Read, Michael Milton, Ian H. Harding, Martin B. Delatycki, David J. Szmulewicz, Paul J. Lockhart, Melanie Bahlo, Haloom Rafehi   +13 more
wiley   +1 more source

Uso da toxina botulínica no controle do bruxismo [PDF]

, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.A toxina botulínica é uma substância produzida pela bactéria Clostridium botulinum, e o seu uso oferece ao cirurgião dentista uma nova alternativa para ...
Francescon, Ariane
core  

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells [PDF]

, 2016
Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human
Leese, C., Rust, A., Binz, T., Davletov, B.   +3 more
core   +1 more source

Functional influence of botulinum neurotoxin type A treatment (Xeomin®) of multifocal upper and lower limb spasticity on chronic hemiparetic gait

Neurology International, 2012
This report describes the modification of hemiplegic shoulder pain and walking velocity through injections of Xeomin®, a new botulinum neurotoxin type A formulation, in a 67-year-old woman with chronic residual left hemiparesis and hemiparetic gait ...
Maurizio Falso, Rosalba Galluso, Andrea Malvicini   +2 more
doaj   +1 more source

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, Volume 41, Issue 10, Page 2755-2766, October 2026.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard, Lucy Dougherty‐de Miguel, German Demidov, Galuh Astuti, Amaia Lasa‐Aranzasti, Ana Cueto‐González, Marta Correa‐Vela, Carlos Lázaro‐Hernández, Charlotte A. Haaxma, Clara D.M. van Karnebeek, David Gómez‐Andrés, Ignacio Iglesias‐Serrano, Jiddeke M. van de Kamp, Jolanda Schieving, Laura Trujillano, Marc Engelen, Beatriz Muñoz‐Cabello, Roderick P.P.W.M. Maas, Thatjana Gardeitchik, Victoria Gonzalez, Annemarie de Vreugd, Cristina Pérez‐Sanchez, Elisabet Lloveras, Erik‐Jan Kamsteeg, Maartje Pennings, Natalia Rey‐Viñets, Javier Sánchez, Ronald van Beek, Antonio Moreno‐Galdó, Lisenka E.L.M. Vissers, Kornelia Neveling, Anna Marcé‐Grau, Machteld M. Oud, Belén Pérez‐Dueñas   +33 more
wiley   +1 more source

Adverse neurological events following botulinum toxin type A: A case series of post-injection seizures and paralysis

Toxicon: X
Within the field of rehabilitation and aesthetic medicine, botulinum neurotoxin (BoNT), particularly type A (BoNT-A), has gained significant popularity for its unique muscle-relaxing properties including muscular spasticity and reducing wrinkles ...
Qiaozhen Li, Chunqiu Dai, Hongbin Wang, Feng Feng, Xiao Xi, Hong Wang, Hua Yuan, Xiaolong Sun   +7 more
doaj   +1 more source

Effects of Ultraviolet Radiation and Heat Treatment on the Inactivation of Clostridium sporogenes Endospores in Honey

Journal of Food Safety, Volume 46, Issue 5, October 2026.
UV‐C‐based treatments, alone or combined with UV‐B and heat, reduced vegetative cells of Clostridium sporogenes in honey while preserving physicochemical and rheological quality. However, endospores showed limited inactivation due to their high resistance, highlighting the need for complementary strategies to improve honey microbiological safety ...
Maria Cecília Evangelista Vasconcelos Schiassi, Bruna Azevedo Balduino, Jhenifer Cristina Carvalho Santos, Tainah Morais Bueno, Ana Cristina Freitas de Oliveira Meira, Gabriela Fonsêca Leal, Roberta Hilsdorf Piccoli, Patrícia Aparecida Pimenta Pereira, Jaime Vilela de Resende   +8 more
wiley   +1 more source

Treatment with Botulinum Neurotoxin Improves Activities of Daily Living and Quality of Life in Patients with Upper Limb Tremor

Tremor and Other Hyperkinetic Movements, 2019
Background: Botulinum neurotoxin’s degree of effectiveness on upper limb tremor is subject to debate; although this treatment reduces the tremor’s amplitude, a clear functional benefit has not been demonstrated.
Alexandre Kreisler, Benoîte Bouchain, Luc Defebvre, Pierre Krystkowiak   +3 more
doaj   +3 more sources

An Investigation of Immunogenicity of Chitosan-Based Botulinum Neurotoxin E Binding Domain Recombinant Candidate Vaccine via Mucosal Route

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Botulism syndrome is caused by serotypes A-G of neurotoxins of Clostridium genus. Neurotoxin binding domain is an appropriate vaccine candidate due to its immunogenic activity.
Mohammad Javad Bagheripour, Firouz Ebrahim, Abbas Hajizadeh, Shahram Nazarian, Jamil Zargan, Jamal Rashidiani   +5 more
doaj