Results 61 to 70 of about 121,700,018 (217)

Emerging Opportunities for Serotypes of Botulinum Neurotoxins

Toxins, 2012
Background: Two decades ago, botulinum neurotoxin (BoNT) type A was introduced to the commercial market. Subsequently, the toxin was approved by the FDA to address several neurological syndromes, involving muscle, nerve, and gland hyperactivity.
John Tapia-Núñez, Michael S. Okun, Aparna Wagle Shukla, Ramon L. Rodriguez, J. Glenn Morris, Zhongxing Peng Chen   +5 more
doaj   +1 more source

Evaluation of a Multipolar MEMS Based Low‐Power Radiofrequency Device for Pain‐Free Facial Rejuvenation: A Prospective Clinical Study

Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.
ABSTRACT Background Noninvasive radiofrequency (RF) therapy has emerged as a prominent approach for facial rejuvenation due to its ability to stimulate collagen remodeling without epidermal ablation. However, conventional RF systems often rely on high thermal output, posing risks of heat‐induced dermal damage. Objective This study aimed to evaluate the
Rongwei Mao, Shengshuo Yan, Aditi A. Sharma, Tony Shum, Yang Zhang   +4 more
wiley   +1 more source

Transynaptic Action of Botulinum Neurotoxin Type A at Central Cholinergic Boutons [PDF]

The Journal of Neuroscience, 2018
Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) at the neuromuscular junction, thus blocking synaptic transmission and weakening overactive muscles.
Caleo, Matteo, Spinelli, Matteo, Colosimo, Francesca, Matak, Ivica, Rossetto, Ornella, Lackovic, Zdravko, Restani, Laura   +6 more
openaire   +4 more sources

Sequencing the botulinum neurotoxin gene and related genes in Clostridium botulinum type E strains reveals orfx3 and a novel type E neurotoxin subtype. [PDF]

, 2007
Three Clostridium botulinum type E strains were sequenced for the botulinum neurotoxin (BoNT) gene cluster, and 11 type E strains, representing a wide biodiversity, were sequenced for the bont/E gene.
Lindström, Miia, Korkeala, Hannu, Chen, Ying, Aarnikunnas, Johannes   +3 more
core   +1 more source

Protocol and Demographics of the RELY-CD Study: Assessing Long-Term Clinical Response to Botulinum Neurotoxin in Cervical Dystonia

Toxins
The RELY-CD study investigated the long-term clinical response to botulinum neurotoxin type A in cervical dystonia within a multicenter, real-world setting.
Benjamin Waeschle, John-Ih Lee, Tristan Kölsche, Robin Jansen, Marta Banach, Stanislaw Ochudlo, Małgorzata Tyślerowicz, Piotr Sobolewski, Sara Sánchez Valiente, Eva López-Valdés, Pablo Mir, Silvia Jesús, Elena Ojeda-Lepe, Ewa Papuć, Pilar Sánchez Alonso, Gabriel Salazar, Georg Comes, Holger Stark, Philipp Albrecht   +18 more
doaj   +1 more source

PEG precipitation coupled with chromatography is a new and sufficient method for the purification of botulinum neurotoxin type B [corrected]. [PDF]

PLoS ONE, 2012
Clostridium botulinum neurotoxins are used to treat a variety of neuro-muscular disorders, as well as in cosmetology. The increased demand requires efficient methods for the production and purification of these toxins.
Yao Zhao, Lin Kang, Shan Gao, Xing Gao, Wenwen Xin, Jinglin Wang   +5 more
doaj   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source

Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)

Neurological Research and Practice, 2019
Background Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia.
Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann, Jens Volkmann   +4 more
doaj   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, Volume 6, Issue 10, Page 392-421, October 2026.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Botulinum-Neurotoxin-A induzierte cholinerge Varikositäten im Caudatus-Putamen-Komplex der Maus: eine quantitative Studie [PDF]

, 2018
Nach intrastriataler Injektion von Botulinum-Neurotoxin-A in C57BL/6-Mäuse zeigten sich Botulinum-Neurotoxin-induzierte Varikositäten, kurz BiVs. Es wurden sowohl zeitliche als auch dosisabhängige Veränderungen der Chat-positiven Varikositätenvolumina ...
Spiewok, Juliane (gnd: 1161741976)
core   +1 more source