Results 41 to 50 of about 121,700,018 (217)

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Radharaman Ray, James Keller, Bal Ram Singh, Prabhati Ray, Peng Zhang, Michael Adler, Dan Li   +6 more
core  

Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome [PDF]

, 2010
Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection
Mayer, Margit E., Yasmin Hocaoglu, Alexander Buchner, Hocaoglu, Yasmin, Buchner, Alexander, Christian G. Stief, Bauer, Ricarda M., Alexander Roosen, Stief, Christian G., May, Florian, Christian Gratzke, Ricarda M. Bauer, Margit E. Mayer, Gratzke, Christian, Florian May, Roosen, Alexander   +15 more
core   +1 more source

Efficacy of IncobotulinumtoxinA (BoNT‐A) Injections in Upper Limb Task‐Specific and Position‐Dependent Tremors

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Task‐specific tremors (TST) and position‐dependent tremors (PDT) are rare isolated focal tremors that impair fine motor control with few effective treatment options. Although botulinum neurotoxin (BoNT) is effective in other tremor syndromes, its evidence in these tremor subtypes remains limited.
Elizabeth K. Boyd, Shangge Jiang, Runjie Bill Shi, Philippe Rizek   +3 more
wiley   +1 more source

Lysozyme gene treatment in testosterone induced benign prostate hyperplasia rat model and comparasion of its’ effectiveness with botulinum toxin injection

International Brazilian Journal of Urology
Objectives: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model.
Osman Ergün, Pinar Aslan Koşar, İbrahim Onaran, Hakan Darici, Alim Koşar   +4 more
doaj   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Substrate-Modified Hydrogels for Autonomous Sensing of Botulinum Neurotoxin Type A

, 2016
Substrate-Modified Hydrogels for Autonomous Sensing of Botulinum Neurotoxin Type
William H. Tepp (226108), Megan L. Frisk (2383357), David J. Beebe (128701), Eric A. Johnson (225183), Guangyun Lin (323901)   +4 more
core   +1 more source

Histopathological changes of the buccal mucosa and skin after botulinum neurotoxin intramuscular injection in rats (immunohistochemical study)

BMC Oral Health
Background A surplus of clinical studies focused mainly on the clinical impacts of botulinum neurotoxin type A disregarding the histopathological changes stemming from its injection.
Gihan S. Hassan, Basant H. Abouzaid, Reda G. Saleh   +2 more
doaj   +1 more source

Intramuscular Botulinum Neurotoxin Serotypes E and A Elicit Distinct Effects on SNAP25 Protein Fragments, Muscular Histology, Spread and Neuronal Transport: An Integrated Histology-Based Study in the Rat

Toxins
Botulinum neurotoxins E (BoNT/E) and A (BoNT/A) act by cleaving Synaptosome-Associated Protein 25 (SNAP25) at two different C-terminal sites, but they display very distinct durations of action, BoNT/E being short acting and BoNT/A long acting.
Vincent Martin, Denis Carre, Heloise Bilbault, Sebastien Oster, Lorenzo Limana, Florian Sebal, Christine Favre-Guilmard, Mikhail Kalinichev, Christian Leveque, Virginie Boulifard, Catherine George, Stephane Lezmi   +11 more
doaj   +1 more source

Pain trajectories in children and adolescents with cerebral palsy: A longitudinal population‐based register study

Developmental Medicine &Child Neurology, EarlyView.
Four pain trajectories were identified in a population‐based register study of 4887 children and adolescents with cerebral palsy: (1) increasing trend, low probability of experiencing pain (20.28%), (2) increasing trend, high probability of experiencing pain (30.30%), (3) decreasing trend (26.85%), and (4) consistently high probability of experiencing ...
May Phyu Sin, Johan Jarl, David L. Roth, Ann I. Alriksson‐Schmidt   +3 more
wiley   +1 more source

Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A [PDF]

, 2008
Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle action potential amplitude decreased. Injection of capsaicin
Carmen Garcia, Joseph McArdle, Kormakur Hognason, Joseph Potian, Baskaran Thyagarajan, Natalia Krivitskaya   +5 more
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