Results 31 to 40 of about 121,700,018 (217)

Botulinum neurotoxin type A: Actions beyond SNAP-25? [PDF]

Toxicology, 2015
Botulinum neurotoxin type A (BoNT/A), the most potent toxin known in nature which causes botulism, is a commonly used therapeutic protein. It prevents synaptic vesicle neuroexocytosis by proteolytic cleavage of synaptosomal-associated protein of 25kDa (SNAP-25).
Matak, Ivica, Lacković, Zdravko
openaire   +4 more sources

CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C.

PLoS ONE, 2015
Botulinum neurotoxins produced by Clostridium botulinum cause flaccid paralysis by inhibiting neurotransmitter release at peripheral nerve terminals. Previously, we found that neurons derived from the murine P19 embryonal carcinoma cell line exhibited ...
Kentaro Tsukamoto, Chikako Ozeki, Tomoko Kohda, Takao Tsuji   +3 more
doaj   +1 more source

Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth

mSystems, 2019
Clostridium butyricum, the type species of the genus Clostridium, is considered an obligate anaerobe, yet it has been shown to grow in the presence of oxygen. C. butyricum strains atypically producing the botulinum neurotoxin type E are the leading cause
Serena Camerini, Lucia Marcocci, Lara Picarazzi, Egidio Iorio, Irene Ruspantini, Paola Pietrangeli, Marco Crescenzi, Giovanna Franciosa   +7 more
doaj   +1 more source

A historical and proteomic analysis of botulinum neurotoxin type/G [PDF]

BMC Microbiology, 2011
Abstract Background Clostridium botulinum is the taxonomic designation for at least six diverse species that produce botulinum neurotoxins (BoNTs). There are seven known serotypes of BoNTs (/A through/G), all of which are potent toxins classified as category A bioterrorism agents.
Rees Jon, Woolfitt Adrian R, Moura Hercules, Terilli Rebecca R, Schieltz David M, Barr John R   +5 more
openaire   +3 more sources

Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons

, 2023
Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like mechanism.
Marco Pirazzini, Montecucco, Cesare, Rossetto, Ornella, Cesare Montecucco, Pirazzini, Marco, Ornella Rossetto   +5 more
core   +1 more source

Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody [PDF]

Toxins, 2016
Botulinum neurotoxins (BoNTs) cause botulism and are the deadliest naturally-occurring substances known to humans. BoNTs have been classified as one of the category A agents by the Centers for Disease Control and Prevention, indicating their potential use as bioweapons.
Yağmur Derman, Katja Selby, Sebastian Miethe, André Frenzel, Yvonne Liu, Christine Rasetti-Escargueil, Arnaud Avril, Thibaut Pelat, Remi Urbain, Alexandre Fontayne, Philippe Thullier, Dorothea Sesardic, Miia Lindström, Michael Hust, Hannu Korkeala   +14 more
openaire   +5 more sources

Complete continence after botulinum neurotoxin type A injections for refractory idiopathic detrusor overactivity incontinence: patient-reported outcome at 4 weeks [PDF]

, 2010
Objective improvement following intradetrusor injections of botulinum neurotoxin type A (BoNTA) is well documented. Although patient-related outcome measures are highly recommended for monitoring overactive bladder symptoms, no study before has dealt ...
Panicker, Jalesh, Khan, Shahid, Kessler, Thomas M, Dasgupta, Prokar, Fowler, Clare J, Elneil, Sohier, Roosen, Alexander, Gonzales, Gwen, Jalesh Panicker, Thomas M. Kessler, Clare J. Fowler, Sohier Elneil, Shahid Khan, Prokar Dasgupta, Alexander Roosen, Gwen Gonzales   +15 more
core   +1 more source

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum

BMC Genomics, 2009
Background Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness. Given the severity of botulism, surprisingly little is known of the population structure, biology, phylogeny or evolution of C.
Twine Susan M, Mason David R, Paul Catherine J, Carter Andrew T, Alston Mark J, Logan Susan M, Austin John W, Peck Michael W   +7 more
doaj   +1 more source

Botulinum Neurotoxin for the Treatment of Neuropathic Pain

Frontiers in Neurology, 2020
Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders.
Gabriella Egeo, Luisa Fofi, Piero Barbanti, Piero Barbanti   +3 more
doaj   +1 more source

Supraglottic Botulinum Toxin Injection Improves Symptoms of Laryngeal Sensory Dysfunction

The Laryngoscope, EarlyView.
In this retrospective cohort of 80 patients with refractory laryngeal sensory symptoms, supraglottic botulinum toxin type A significantly improved Laryngeal Hypersensitivity Questionnaire, Reflux Symptom Index, and Cough Severity Index scores at a mean of 5.2 weeks, while Voice Handicap Index‐10 scores remained unchanged.
Daniel Novakovic, Katrina Sandham, Thomas Emslie Stewart, James Jordan Johnston   +3 more
wiley   +1 more source