Results 21 to 30 of about 121,700,018 (217)
Botulinum neurotoxin type A in neurology: update
Neurology International, 2015 This paper reviews the current and most neurological (central nervous system, CNS) uses of the botulinum neurotoxin type A. The effect of these toxins at neuromuscular junction lends themselves to neurological diseases of muscle overactivity, particularly abnormalities of muscle control.
Orsini, Marco +12 more
openaire +3 more sources
In the human urothelium and suburothelium, intradetrusor botulinum neurotoxin type A does not induce apoptosis: preliminary results [PDF]
, 2010 Intradetrusor injections of botulinum neurotoxin type A (BoNTA) are emerging as the preferred second-line treatment for neurogenic and idiopathic overactive bladder (OAB).
Khan, Shahid +13 more
core +2 more sources
Neurologic uses of botulinum neurotoxin type A
Neuropsychiatric Disease and Treatment, 2008 This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized
Ney,John P, Joseph,Kevin R
openaire +5 more sources
A Cell Line for Detection of Botulinum Neurotoxin Type B [PDF]
Frontiers in Pharmacology, 2017 Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleavage of the neuron-specific proteins, SNAP-25 and ...
Rust, A. +7 more
openaire +5 more sources
Action of Botulinum Neurotoxin E Type in Experimental Epilepsies
Toxins, 2023 Botulinum neurotoxins (BoNTs) are zinc endopeptidases produced by the Clostridium genus of anerobic bacteria, largely known for their ability to cleave synaptic proteins, leading to neuromuscular paralysis. In the central nervous system, BoNTs are known to block the release of glutamate neurotransmitter, and for this reason, researchers explored the ...
Flavia Antonucci, Yuri Bozzi
openaire +4 more sources
Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]
, 2013 Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ +13 more
core +1 more source
Onset dynamics of type A botulinum neurotoxin-induced paralysis [PDF]
Journal of Pharmacokinetics and Pharmacodynamics, 2008 Experimental studies have demonstrated that botulinum neurotoxin serotype A (BoNT/A) causes flaccid paralysis by a multi-step mechanism. Following its binding to specific receptors at peripheral cholinergic nerve endings, BoNT/A is internalized by receptor-mediated endocytosis.
Lebeda, Frank J. +3 more
openaire +2 more sources
PLoS ONE, 2014 Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover +5 more
doaj +1 more source
Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study [PDF]
, 2009 Aim: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. Methods: Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport (R)). The primary endpoint was reduction in
Toelle, Thomas +13 more
core +1 more source
PLoS ONE, 2013 Sanger and shotgun sequencing of Clostridium botulinum strain Af84 type Af and its botulinum neurotoxin gene (bont) clusters identified the presence of three bont gene clusters rather than the expected two. The three toxin gene clusters consisted of bont
Nir Dover +6 more
doaj +1 more source