Results 171 to 180 of about 55,357 (300)

Aicardi‐Goutières Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant‐Negative Effect of the ADAR1 c.3019G>A Variant

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Aicardi–Goutières syndrome type 6 (AGS6) is a genetically determined autoinflammatory disorder, classically inherited in an autosomal recessive manner. We report a Czech child with a heterozygous ADAR1 NM_001111.5:c.3019G>A variant causing AGS6.
Katerina Turan   +11 more
wiley   +1 more source

Successful Surgical Management of Tonic Toe Flexion Reflex by Tenotomy of the Flexor Digitorum Longus Tendon Under Wide‐Awake Local Anesthesia: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT The tonic toe flexion reflex may present as a dynamic toe deformity only during weight‐bearing and can be overlooked. Flexor digitorum longus tenotomy under wide‐awake local anesthesia allows real‐time confirmation of symptom resolution and represents a practical surgical option when conservative treatment fails.
Yoichi Toyoshima   +2 more
wiley   +1 more source

Intravesical Botulinum Toxin Type A for an Overactive Bladder: A Single-Center Audit. [PDF]

open access: yesCureus
Abolanle P   +5 more
europepmc   +1 more source

Shared and Specific Patterns of Brain Functional Network Abnormalities in Patients With Idiopathic Dystonia and Across Subtypes

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
The whole brain functional network based on brainnetome atlas with 28 cerebellar subregions was constructed and topological parameters were calculated and compared based on graph theoretical analyses between patients with idiopathic dystonia and healthy controls, as well as further subgroup analyses.
Gang Liu   +12 more
wiley   +1 more source

Evolution of Drug Development Trends in Multiple Sclerosis: Analysis of Mainland China and Global Landscapes From 2004 to 2024

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
This registry‐based analysis of 1183 MS clinical trials (2004–2024) shows sustained global activity and a marked increase in mainland China after 2018, predominantly driven by late‐phase and bioequivalence studies. Trial density varied across regions, and IFNAR, CD20, and S1PR1 were the most frequently investigated targets. ABSTRACT Background Multiple
Chaoyang Chen   +7 more
wiley   +1 more source

Why, When, and How to Treat Dynamic Forehead Lines with Botulinum Toxin Type A. [PDF]

open access: yesToxins (Basel)
de Sanctis Pecora C   +3 more
europepmc   +1 more source

Endoscopic resection of polypoid solitary rectal ulcer: A novel first‐line therapeutic strategy using snare‐assisted mucosal and fibrosis resection

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
Abstract Objectives To propose a novel first‐line endoscopic therapy for treating polypoid lesions in solitary rectal ulcer syndrome (P‐SRUS), the rarest and most challenging subtype of SRUS, which encompasses various endoscopic findings including mucosal erythema, superficial or deep ulcers, and polypoid lesions.
Mojgan Forootan   +12 more
wiley   +1 more source

Enhanced Visualization of the Distal Myotomy Endpoint during Peroral Endoscopic Myotomy Using Indocyanine Green With Infrared Imaging

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
Indocyanine green with infrared imaging (ICG‐IRI) provides real‐time fluorescence visualization of the distal myotomy endpoint during peroral endoscopic myotomy (POEM). In this study of 39 patients, ICG‐IRI achieved a 94.9% success rate in fluorescence detection and significantly improved esophageal relaxation and symptoms.
Yuichiro Ikebuchi   +14 more
wiley   +1 more source

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