Results 81 to 90 of about 21,819 (222)

RESPONSE OF TYPE B AND E BOTULINUM TOXINS TO PURIFIED SULFHYDRYL-DEPENDENT PROTEASE PRODUCED BY CLOSTRIDIUM BOTULINUM TYPE F

Japanese Journal of Medical Science and Biology, 1977
A sulfhydryl-dependent protease (SHP) was purified from a culture of Clostridium botulinum type F. The enzyme can activate type E progenitor toxin completely but type B progenitor toxin only partially. This may suggest that SHP by itself could completely activate the toxin of proteolytic C. botulinum types A and F in culture.
OHISHI, IWAO, SAKAGUCHI, GENJI
openaire   +3 more sources

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Botulism in Brazil, 2000-2008: epidemiology, clinical findings and laboratorial diagnosis Botulismo no Brasil, 2000-2008: epidemiologia, achados clínicos e diagnóstico laboratorial

Revista do Instituto de Medicina Tropical de São Paulo, 2010
Botulism is a rare and potentially lethal illness caused by Clostridium botulinum neurotoxin. We describe the findings of a laboratorial investigation of 117 suspected cases of botulism reported to the surveillance system in Brazil from January 2000 to ...
Ruth Estela Gravato Rowlands, Christiane Asturiano Ristori, Giselle Ibette S. Lopez Lopes, Ana Maria Ramalho de Paula, Harumi Sakuma, Raquel Grigaliunas, Roberto Lopreato Filho, Dilma Scala Gelli, Maria Bernadete de Paula Eduardo, Miyoko Jakabi   +9 more
doaj   +1 more source

Expanding the Phenotype of PARK‐PRKN to Spastic Paraplegia: A Report of Two Cases

Movement Disorders Clinical Practice, EarlyView.
Nicolas Geoffre, Thomas Ollivier, Guillaume Baille, Luc Defebvre, Vincent Huin, Eugenie Mutez   +5 more
wiley   +1 more source

The predictive nature of diagnostic nerve blocks for lower extremity spasticity management with botulinum toxin and neurotomy: A systematic review

PM&R, EarlyView.
Abstract Introduction/Objective Diagnostic nerve blocks (DNBs) involve the injection of anesthetic around peripheral nerves to temporarily reduce motor tone. Although they are used clinically to inform spasticity treatment with neurotomy and chemodenervation, there is little research exploring the predictive nature of DNBs.
Katherine Archibold, Jeremy Slayter, Emily M. Krauss, Alexander Whelan   +3 more
wiley   +1 more source

[Immunochemical study of the toxin of C1. botulinum type E].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1976
Toxins extracted from the cells and the culture fluid of C1. butulinum type E had a similar mol wt and antigenic composition. Trypsin activation led to the appearance of an additional antigen. Coefficient of the cell toxin activation was much greater than the coefficient of activation of the toxin contained in the culture fluid.
M V, Ispolatovskaia, L N, Reshetnikova, L I, Anisimova   +2 more
openaire   +1 more source

Activation of Clostridium botulinum Type E Toxin Purified by Two Different Procedures

Microbiology, 1986
Clostridium botulinum type E toxin was purified from culture supernates and from cell extracts by two methods. The specific activity [2 X 10(4) mouse LD50 (mg protein)-1] of the toxin purified from cell extract under slightly acidic conditions was lower than that [3 X 10(5) LD50 (mg protein)-1] of the toxin purified from culture supernate under ...
N, Yokosawa, K, Tsuzuki, B, Syuto, K, Oguma   +3 more
openaire   +2 more sources

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

[Characteristics of the activation of type E. Cl. botulinum toxins].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1982
Molecular changes occurring in type E. Cl. botulinum single-chain toxin as the result of treatment with trypsin under different conditions were studied. The intensity of activation of the precursor and the ensuing changes of its molecular structure were found to depend on the pH of the medium.
G A, Levdikova, L V, Klimacheva, M V, Ispolatovskaia, T I, Bulatova, L I, Anisimova   +4 more
openaire   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source