Results 81 to 90 of about 16,551 (199)

Atypical MAPKs in cancer

The FEBS Journal, Volume 292, Issue 9, Page 2173-2188, May 2025.
Mitogen‐activated protein kinases (MAPKs) regulate various cellular processes, including proliferation, differentiation, and motility. Alterations in these signalling pathways can lead to various diseases, including cancer. The atypical MAPKs ERK3 (MAPK6), ERK4 (MAPK4), ERK7/8 (MAPK15) and NLK have long been neglected in kinomic studies.
Katrin Dahm, Parthiban Vijayarangakannan, Hans‐Peter Wollscheid, Hansjörg Schild, Krishnaraj Rajalingam   +4 more
wiley   +1 more source

A multicenter, prospective, single‐arm study of 60‐day peripheral nerve stimulation of the occipital nerves for the treatment of headache

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The aim of this study was to evaluate the efficacy and safety of a 60‐day peripheral nerve stimulation (PNS) treatment targeting the occipital nerves for reducing pain and improving function in individuals diagnosed with cervicogenic headache or occipital neuralgia. Background Headache conditions are prevalent and commonly disabling,
Genaro G. Gutierrez, Zachary L. McCormick, Mitchell P. Engle, Christopher A. Gilmore, Matthew J. Pingree, Jason E. Pope, David J. DiBenedetto, Narayan R. Kissoon, Puneet K. Sayal, Claire A. Zurn, Nathan D. Crosby, Joseph W. Boggs   +11 more
wiley   +1 more source

Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A [PDF]

, 2008
Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle action potential amplitude decreased. Injection of capsaicin
Baskaran Thyagarajan, Carmen Garcia, Joseph McArdle, Joseph Potian, Kormakur Hognason, Natalia Krivitskaya   +5 more
core   +1 more source

Correlating Optical Coherence Tomography and Other Noninvasive Imaging Features With Atrophic and Hypertrophic Skin Photoaging

International Journal of Dermatology, EarlyView.
ABSTRACT Background According to morphological and clinical differences, atrophic (AP) and hypertrophic (HP) skin photoaging types have been reported. The current study examines the correlation between optical coherence tomography (OCT) and dynamic‐OCT (D‐OCT) features in subjects with skin photoaging types classified as AP, HP, or controls ...
Stefania Guida, Silvana Ciardo, Hassan Galadari, Barbara De Pace, Marco Manfredini, Johanna Chester, Shaniko Kaleci, Ilaria Proietti, Carmen Cantisani, Simone Michelini, Camilla Chello, Camila Scharf, Caterina Longo, Steven P. Nisticò, Francesca Farnetani, Franco Rongioletti, Giovanni Pellacani   +16 more
wiley   +1 more source

Comorbid Diabetes Mellitus Contributes to Residual Overactive Bladder After Transurethral Surgery for Benign Prostatic Hyperplasia

International Journal of Urology, EarlyView.
ABSTRACT Objectives This study aimed to investigate the factors associated with residual overactive bladder after transurethral surgery for benign prostatic hyperplasia. Methods This study retrospectively analyzed male patients aged 50 years or older who underwent transurethral surgery for benign prostatic hyperplasia with overactive bladder between ...
Koji Miki, Keisuke Kiba, Daisuke Maenosono, Yasunori Akashi, Mamoru Hashimoto, Yutaka Yamamoto, Kazutoshi Fujita, Akihide Hirayama   +7 more
wiley   +1 more source

Sternocleidomastoid Omohyoid Entrapment of the Internal Jugular Vein Causing Vertigo and Headaches

Clinical Otolaryngology, EarlyView.
Yoon‐Hee Cha, Mahmood Gharib, Kayla Chan, Joseph Karam   +3 more
wiley   +1 more source

Hyperhidrosis: don't sweat it

Internal Medicine Journal, EarlyView.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Darier disease: Current insights and challenges in pathogenesis and management

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 942-951, May 2025.
Darier disease (DD) is characterized by the following: Disrupted Ca2+ gradients, impaired desmosomes, impaired keratinocyte differentiation, type 17 inflammation, DC and LC ↓, Th17 cells ↑. DD treatment: First line: keratinocyte focused and/or anti‐inflammatory. Second line: experimental approaches like specific targeting of the inflammatory infiltrate.
Monika Ettinger, Susanne Kimeswenger, Isabella Deli, Judith Traxler, Sabine Altrichter, Petar Noack, Jakob D. Wikstrom, Emmanuella Guenova, Wolfram Hoetzenecker   +8 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 899-941, May 2025.
HS treatment algorithm. Abstract Introduction This second part of the S2k guidelines is an update of the 2015 S1 European guidelines. Objective These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS ...
C. C. Zouboulis, F. G. Bechara, F. Benhadou, V. Bettoli, Z. Bukvić Mokos, V. Del Marmol, M. Dolenc‐Voljč, E. J. Giamarellos‐Bourboulis, Ø. Grimstad, P. Guillem, B. Horváth, R. E. Hunger, J. R. Ingram, D. Ioannidis, E. Just, L. Kemény, B. Kirby, A. I. Liakou, B. M. McGrath, A. V. Marzano, Ł. Matusiak, A. Molina‐Leyva, A. Nassif, M. Podda, E. P. Prens, F. Prignano, H. Raynal, M. Romanelli, D. M. L. Saunte, A. Szegedi, J. C. Szepietowski, T. Tzellos, S. Valiukevičienė, H. H. van der Zee, K. R. van Straalen, B. Villumsen, G. B. E. Jemec   +36 more
wiley   +1 more source