Results 81 to 90 of about 18,175 (274)

Guideline on the use of onabotulinumtoxinA in chronic migraine. a consensus statement from the European Headache Federation [PDF]

, 2018
OnabotulinumtoxinA is being increasingly used in the management of chronic migraine (CM). Treatment with onabotulinumtoxinA poses challenges compared with traditional therapy with orally administered preventatives.
Ahmed, Fayyaz, Ashina, Messoud, Bendtsen, Lars, Hospital Universitari Vall d'Hebron, Martelletti, Paolo, Mitsikostas, Dimos, Pozo-Rosich, Patricia, Sacco, Simona, Universitat Autònoma de Barcelona   +8 more
core   +3 more sources

Segmental and Multifocal Isolated Dystonias: Similarities and Differences

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Whether the traditional distinction between segmental and multifocal dystonia is clinically or scientifically useful remains unclear. Objective To evaluate whether idiopathic isolated adult‐onset segmental and multifocal dystonia can be differentiated based on clinical features other than the contiguity of affected body regions ...
Hyder A. Jinnah, Vittorio Velucci, Daniele Belvisi, Gamze Kilic‐Berkmen, Joel S. Perlmutter, Laura J. Wright, Christine Klein, Jeanne S. Feuerstein, Steven Bellows, Joseph Jankovic, Cynthia Comella, Richard L. Barbano, Aparna Wagle Shukla, Stephen G. Reich, Mark S. LeDoux, Alberto J. Espay, Kevin R. Duque, Florence C.F. Chang, Victor S.C. Fung, Sarah Pirio‐Richardson, Carmen Terranova, Emile S. Moukheiber, Sarah Idrissi, Barbara Vitucci, Susan H. Fox, Samuel Frank, Natividad Stover, Brian D. Berman, Rachel Saunders‐Pullman, William G. Ondo, Christopher L. Groth, Marcello Esposito, Laura Avanzino, Francesco Bono, Roberto Erro, Marcello Mario Mascia, Antonella Muroni, Alfredo Berardelli, Giovanni Defazio   +38 more
wiley   +1 more source

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R, Conrad, Fraser, Espinoza, Yero, Garcia-Rodriguez, Consuelo, Kimbler, Angie, Kraus, Carl N, Marks, James D, Martinez, Zachary, Pham, Khanh, Riling, Kathryn, Snow, Doris M, Tomic, Milan T, Wong, David   +12 more
core  

Investigating Sleep Concerns in Cervical Dystonia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Heterogenous, small cohorts, and co‐occurrence of pain and psychiatric burden complicate understanding of sleep in dystonia. Objective To investigate sleep concerns in cervical dystonia (CD). Methods Longitudinal data from CD‐PROBE on subjects who were toxin‐naïve, new to practice, or without injections for at least 16 weeks were ...
Abhimanyu Mahajan, David Andrés González, Cynthia Comella   +2 more
wiley   +1 more source

Iatrogenic Botulism After Botulinum Toxin Type A Injections

Clinical Neuropharmacology, 2010
Therapeutic use of botulinum toxin type A (BT/A) is well known, effective, and safe. Iatrogenic botulism that presents with generalized weakness, dysphagia, and respiratory distress is a rare but significant complication in BT/A treatment. In this study, we report 4 patients who developed iatrogenic botulism after receiving therapeutic doses of BT/A ...
Çoban, Arzu, Matur, Zeliha, Hanağası, Haşmet Ayhan, Parman, Yeşim Gülşen   +3 more
openaire   +3 more sources

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells [PDF]

, 2016
Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human
Binz, T., Davletov, B., Leese, C., Rust, A.   +3 more
core   +1 more source

Clinical Algorithm‐Guided Approach to Botulinum Toxin Type A Treatment for Axial Postural Abnormalities in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Axial postural abnormalities (APAs) are common, disabling complications of Parkinson's disease (PD) with unclear pathophysiology. The presence of hyperactivity in multiple trunk muscles supports the use of botulinum toxin (BTA). However, its application is complex, due to the lack of standardized clinical and electrophysiological ...
Giacomo Argenziano, Giovanna Squintani, Serena Camozzi, Ilaria Di Vico, Marialuisa Gandolfi, Carlo Alberto Artusi, Michele Tinazzi, Christian Geroin   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Real-World Safety And Effectiveness Of OnabotulinumtoxinA Treatment Of Crow’s Feet Lines And Glabellar Lines: Results Of A Korean Postmarketing Surveillance Study

Clinical, Cosmetic and Investigational Dermatology, 2019
Dong-Jin Yi,1 Seongjin Hwang,2 JunHyuk Son,3 Irina Yushmanova,4 Krystal Anson Spenta,5 Suzanne St.Rose6 1BLS Clinic, Seoul, Republic of Korea; 2Fulore Clinic, Seoul, Republic of Korea; 3Department of Ophthalmology, Yeungnam University College of Medicine,
Yi DJ, Hwang S, Son J, Yushmanova I, Anson Spenta K, St.Rose S   +5 more
doaj  

Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins [PDF]

, 2014
Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2 ...
Adler, Michael, Borrell, Andrew, Demogines, Ann, Dong, Min, Johnson, Eric A., Liu, Huisheng, Peng, Lisheng, Sawyer, Sara L., Tao, Liang, Tepp, William H., Zhang, Su-Chun   +10 more
core   +3 more sources