Results 121 to 130 of about 21,762 (295)

Comparison of botulinum toxins for treatment of movement disorders: real-world utilization and cost analysis in a national Medicare population. [PDF]

J Manag Care Spec Pharm, 2021
Kazerooni R, Watanabe JH.
europepmc   +1 more source

Endoscopic small bowel therapies for type 2 diabetes

Nutrition in Clinical Practice, EarlyView.
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel, Zehra Naseem, Prisha Gattu, Stephen Firkins, Roberto Simons‐Linares   +4 more
wiley   +1 more source

Recombinant synthesis and immunological characterization of single-domain antibodies against botulinum neurotoxin serotype A and B

Tạp chí Kiểm nghiệm và An toàn thực phẩm
Nanobodies which are single-domain antibodies derived from the Variable Heavy domain of Heavy-chain-only antibodies (VHHs) found in camels and sharks, represent a novel approach for enhancing the detection and neutralization of food toxins.
Luong Trung Hieu, Bui Thi Thu Hoai, Phan Thi Thanh Thuy, Nguyen Le Duc Hai, Nguyen Thi Anh Nguyet, Pham Bao Yen, Nguyen Thi Hong Loan, Phan Tuan Nghia, Nguyen Thanh Trung, Le Phuong Linh, Trinh Van Toan, Le Thi Hong Nhung   +11 more
doaj   +1 more source

Procedural‐Based Contemporary Management of Bell's Palsy Long‐Term Sequelae: A Narrative Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To describe the long‐term sequelae of Bell's palsy and summarize available treatment options, including recent advances, so that general otolaryngologists and other practitioners are aware of the clinical findings and available interventions. Data Sources PubMed.
Robert M. Frederick, Rhorie Kerr, Eric Dobratz, William Dougherty   +3 more
wiley   +1 more source

Gut mucin fucosylation dictates the entry of botulinum toxin complexes

Nature Communications
Botulinum toxins (BoNTs) produced by Clostridium botulinum are the most potent known bacterial toxins. The BoNT complex from serotype B-Okra (LPTC/BOkra) exerts at least 80-fold higher oral toxicity in mice compared with that from serotype A1 (L-PTC/A62A)
Sho Amatsu, Takuhiro Matsumura, Chiyono Morimoto, Sunanda Keisham, Yoshiyuki Goto, Tomoko Kohda, Jun Hirabayashi, Kengo Kitadokoro, Takane Katayama, Hiroshi Kiyono, Hiroaki Tateno, Masahiko Zuka, Yukako Fujinaga   +12 more
doaj   +1 more source

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals [PDF]

, 2016
AZARNIA TEHRAN, Domenico, Binz, Thomas, Leka, Oneda, Lista, Florigio, Mattarei, Andrea, Montecucco, Cesare, Pirazzini, Marco, Rossetto, Ornella   +7 more
core   +1 more source

A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts

Pediatric Discovery, EarlyView.
ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs are diverse and not standardized.
Emily Kim, Rebeka Dejenie, Caroline Kim, Russell Reid   +3 more
wiley   +1 more source

Bacterial toxins modifying the actin cytoskeleton [PDF]

, 2010
Numerous bacterial toxins recognize the actin cytoskeleton as a target. The clostridial binary toxins (Iota and C2 families) ADP-ribosylate the actin monomers causing the dissociation of the actin filaments.
Claude Bouchaud, Jean Christophe Marvaud, Jean-François Richard, Laetitia Petit, Maryse Gibert, Michel R. Popoff   +5 more
core   +2 more sources

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source