Results 131 to 140 of about 119,004 (251)
Journal of the Egyptian Women’s Dermatologic SocietyIntroduction Vulvodynia is a painful and constant vulvar discomfort. This condition is often described as a searing or stinging sensation, with an increased awareness of pain (hyperalgesia) and pain sensitivity (allodynia).
Uzma D.M. Rajar +2 more
doaj +1 more source
Pathophysiology of Delayed Gastric Conduit Emptying After Oesophagectomy: A Multicentre Cohort Study
ANZ Journal of Surgery, EarlyView.In this multicentre study of 272 patients, early and late delayed gastric conduit emptying after oesophagectomy emerged as distinct phenotypes. Early DGCE was predicted by open surgery, whereas late DGCE was predicted by GOJ tumour location and postoperative complications.
Jonathan Sivakumar +10 more
wiley +1 more source
Bacterial food poisoning toxins as biothreat agents
, 2016 Biological toxins are chemical compounds produced by various living organisms. Botulinum toxin is the most toxic substance produced by a biological organism.
Pyötsiä, Hilla
core
Third‐Line Overactive Bladder Treatments: Cost–Benefit Analysis in an Australian Public Hospital
ANZ Journal of Surgery, EarlyView.ABSTRACT Introduction and Objectives To review the efficacy and cost‐effectiveness of third‐line overactive bladder (OAB) managements, including percutaneous tibial nerve stimulation (PTNS), intravesical botulinum toxin A (Botox) and sacral neuromodulation (SNM) in the urology department of a tertiary public hospital.
Rowan Klein Nulend +4 more
wiley +1 more source
Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins. [PDF]
Toxins (Basel), 2020 Hassell TJW, Charles D.
europepmc +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
Dystonia, an overview; classification, etiology and treatment
Fysioterapeuten, 2017 Introduction: Dystonia is a neurological condition which leads to involuntary muscle contractions and is little known among physiotherapists and doctors.
Jeanette Koht +3 more
doaj
Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents
British Journal of Pharmacology, EarlyView.Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić +10 more
wiley +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source