Results 61 to 70 of about 40,647 (354)
Arquivos de Neuro-PsiquiatriaBackground The movement disorder known as hemifacial spasm is characterized by involuntary contractions of the muscles that are innervated by the facial nerve. The treatment of choice for this condition is botulinum toxin injections.
Fátima de Menezes Dantas +4 more
doaj +1 more source
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]
, 2020 Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng +8 more
core
Clinical Anatomy, EarlyView.ABSTRACT The orbicularis oculi muscle (OOc) is strongly associated with facial aging as its contraction causes the formation of crow's feet. Botulinum neurotoxin (BoNT) injection is a representative treatment targeting muscle. The aim of this study was to demonstrate the anatomical relationship between the OOc and the zygomaticus complex muscles, and ...
Jiong‐Zhen Piao +3 more
wiley +1 more source
Fluid flow enhances the effectiveness of toxin export by aquatic microorganisms: a first-passage perspective on microvilli and the concentration boundary layer [PDF]
, 2014 A central challenge for organisms during development is determining a means to efficiently export toxic molecules from inside the developing embryo. For aquatic microorganisms, the strategies employed should be robust with respect to the variable ocean environment and limit the chances that exported toxins are reabsorbed.
arxiv +1 more source
Rheumatoid arthritis and Hailey‐Hailey disease treated with methotrexate
International Journal of Rheumatic Diseases, Volume 26, Issue 1, Page 157-159, January 2023., 2023 Abstract We report a rare case of long‐standing Hailey‐Hailey disease in a Caucasian Portuguese 69‐year‐old woman, recently diagnosed with rheumatoid arthritis. The patient's skin lesions remained active and exudative despite topical and oral treatments with corticosteroids, tetracyclines, antifungals, and oral treatment with azathioprine.
Beatriz Mestre +2 more
wiley +1 more source
Botulinum neurotoxin X lacks potency in mice and in human neurons
mBioBotulinum neurotoxins (BoNTs) are a class of toxins produced by Clostridium botulinum (C. botulinum) and other species of Clostridia. BoNT/X is a putative novel botulinum neurotoxin identified through genome sequencing and capable of SNARE cleavage, but ...
Brieana M. Gregg +8 more
doaj +1 more source
Botulinum Toxins in Medical and Cosmetic Dermatology
European Medical Journal Dermatology, 2021 Background: Botulinum toxin (BoNT), a bacterially produced neurotoxin, is a mainstay in the dermatologic armamentarium. Although BoNT is commonly used to treated rhytides associated with ageing, it can be employed for a variety of other cosmetic ...
Margit Juhász +2 more
doaj +1 more source
Single-species population models with age structure and psychological effect in a polluted environment [PDF]
arXiv, 2022 This paper considers a single-population model with age structure and psychological effects in a polluted environment. We divide the single population into two stages of larval and adult structure. The model uses Logistic input, and the larvae are converted into adult bodies by constant ratio. We only consider adulthood.
arxiv
Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]
, 2013 Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason +5 more
core +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source