Results 91 to 100 of about 1,238,535 (282)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Functions of Well-Bounded Operators [PDF]

open access: yesProceedings of the American Mathematical Society, 1984
It is shown that if A A is a well-bounded operator of type (B), and if f f is of bounded variation and piecewise monotone, then f ( A ) f(A) is also well bounded of type (B).
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Commuting Toeplitz Operators With Mixed Quasihomogeneous and Analytic Symbols

open access: yesJournal of Mathematics
A major open problem in the theory of Toeplitz operators on the analytic Bergman space over the unit disk is the characterization of the commutant of a given Toeplitz operator, that is, the set of all bounded Toeplitz operators that commute with it.
Aissa Bouhali   +2 more
doaj   +1 more source

Estimation of Scale Parameter Under a Bounded Loss Function [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2016
The quadratic loss function has been used by decision-theoretic statisticians and economists for many years.  In this paper  the estimation of scale parameter under a bounded loss function, which is adequate for assessing quality and quality improvement,
N. Sanjari Farsipour
doaj  

Coefficients estimates of some subclasses of analytic functions related with conic domain

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013
In this paper, the authors determine the coefficient bounds for functions in certain subclasses of analytic functions related with the conic regions, which are introduced by using the concept of bounded boundary and bounded radius rotations.
Malik Sarfraz Nawaz   +3 more
doaj   +1 more source

A new proof of the Krzyz conjecture for n = 3 [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Математика. Механика. Информатика
The purpose of this paper is to solve the problem of the sharp estimation of the modulus of the third Taylor coefficient on the class of holomorphic bounded nonvanishing in the unit disk functions (hereafter referred to as the class of bounded ...
Stupin, Denis Leonidovich
doaj   +1 more source

ON p-ADIC BOUNDED FUNCTIONS

open access: yesMemoirs of the Faculty of Science, Kyusyu University. Series A, Mathematics, 1992
Let \(\mathbb{N}\) be equipped with the \(p\)-adic metric, let \(f: \mathbb{N}\to\mathbb{C}_ p\) (where \(\mathbb{C}_ p\) is the completion of the algebraic closure of the field of the \(p\)-adic numbers) be bounded. The authors establish relationships between the Mahler coefficients \(\Delta^ i f(0)=\sum^ i_{j=0}(-1)^{i-j}{i\choose j} f(j)\) and the `\
Ikeda, Kazuo   +2 more
openaire   +2 more sources

Complexity and fractal dimensions for infinite sequences with positive entropy

open access: yes, 2017
The complexity function of an infinite word $w$ on a finite alphabet $A$ is the sequence counting, for each non-negative $n$, the number of words of length $n$ on the alphabet $A$ that are factors of the infinite word $w$.
Mauduit, Christian   +1 more
core  

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