HMGB1-BoxA gene therapy in reversing cisplatin resistance in non-small cell lung cancer [PDF]
PLoS ONECisplatin is a widely used chemotherapy agent in the treatment of non-small cell lung cancer (NSCLC). However, its clinical efficacy is limited by the development of drug resistance in patients with NSCLC.
Pithi Chanvorachote +2 more
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High mobility group box 1 inhibition by BoxA attenuates ovalbumin-induced allergic rhinitis in mice
Autoimmunity, 2022 This study was designed to evaluate the effects of BoxA on allergic rhinitis (AR). Ovalbumin (OVA)-induced AR mice model was employed and BoxA was administered to AR mice.
Liyan Yue +6 more
exaly +4 more sources
High-Mobility Group Box 1 Inhibitor BoxA Alleviates Neuroinflammation-Induced Retinal Ganglion Cell Damage in Traumatic Optic Neuropathy [PDF]
International Journal of Molecular Sciences, 2022 Traumatic optic neuropathy (TON) is a significant cause of vision loss and irreversible blindness worldwide. It is defined as retinal ganglion cell death and axon degeneration caused by injury. Optic nerve crush (ONC), a well-validated model of TON, activates retinal microglia and initiates neuroinflammation.
Wenru Su, Huan Yu, Yongxin Zheng
exaly +4 more sources
Bacteriophage genotyping using BOXA repetitive-PCR [PDF]
BMC Microbiology, 2020 Background Repetitive-PCR (rep-PCR) using BOXA1R and BOXA2R as single primers was investigated for its potential to genotype bacteriophage. Previously, this technique has been primarily used for the discrimination of bacterial strains.
Dragica Damnjanovic +4 more
doaj +4 more sources
Use of an antagonist of HMGB1 in mice affected by malignant mesothelioma: a preliminary ultrasound and optical imaging study [PDF]
European Radiology Experimental, 2022 Background Malignant mesothelioma (MM) is an aggressive tumor, with a poor prognosis, usually unresectable due to late diagnosis, mainly treated with chemotherapy.
Massimo Venturini +15 more
doaj +2 more sources
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma [PDF]
EMBO Molecular Medicine, 2021 Boosting antitumor immunity has emerged as a powerful strategy in cancer treatment. While releasing T‐cell brakes has received most attention, tumor recognition by T cells is a pre‐requisite. Radiotherapy and certain cytotoxic drugs induce the release of
Rosanna Mezzapelle +23 more
doaj +2 more sources
Evidence that a nucleotide sequence, “boxA,” is involved in the action of the NusA protein [PDF]
Cell, 1983 We report the isolation of a mutation, boxA1, in the nutR region of the phage lambda genome. The nutR region, located downstream of the pR promoter, includes the site nutR where the lambda N protein is thought to act to render subsequent transcription termination-resistant.
Friedman, David I., Olson, Eric R.
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Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro [PDF]
Scientific Reports, 2021 Traumatic brain injury (TBI) is associated with poor clinical outcomes; autopsy studies of TBI victims demonstrate significant oligodendrocyte progenitor cell (OPC) death post TBI; an observation, which may explain the lack of meaningful repair of ...
R. Ved +7 more
doaj +2 more sources
Boxa i procés de civilització en la societat espanyola [PDF]
Apunts. Educació física i esports, 2009 Durant el segle xx la boxa, a la societat espanyola, va passar de ser un esport de masses a ser una activitat oblidada a final dels anys setanta. La boxa, sumida en aquell temps en una profunda crisi institucional i esportiva, no va poder resistir les ...
Sánchez García, Raúl
core +2 more sources
Involvement of boxA Nucleotides in the Formation of a Stable Ribonucleoprotein Complex Containing the Bacteriophage λ N Protein [PDF]
Journal of Biological Chemistry, 1998 The association of the transcriptional antitermination protein N of bacteriophage lambda with Escherichia coli RNA polymerase depends on nut site RNA (boxA + boxB) in the nascent transcript and the host protein, NusA. This ribonucleoprotein complex can transcribe through Rho-dependent and intrinsic termination sites located up to several hundred base ...
Jack Greenblatt
exaly +3 more sources