Results 51 to 60 of about 122,466 (202)

Effect of Pentadecapeptide BPC 157 on Hypercalcaemia in Rats [PDF]

Liječnički vjesnik, 2023
Isolated from gastric juice stable pentadecapeptide BPC 157 has already shown cytoprotective and organoprotective properties. Beneficial effects of BPC 157 on various organic systems such as cardiovascular, digestive, skeletomuscular system have already ...
Matej Lacković, Helen Marie Chiddenton, Sara Burić   +2 more
doaj   +2 more sources

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review. [PDF]

HSS J
Background: Body protection compound-157 (BPC-157) is a naturally occurring gastric peptide that promotes mucosal integrity and homeostasis. Preclinical studies show its potential for promoting healing in musculoskeletal injuries such as fractures ...
Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM.   +6 more
europepmc   +2 more sources

Effects of diclofenac, L-NAME, L-Arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation deterioration in 24 hour-short-bowel rats [PDF]

, 2016
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Drmić, Domagoj, Kolenc, Danijela, Lojo, Nermin, Rašić, Žarko, Seiwerth, Sven, Sever, Marko, Sikirić, Predrag, Vukušić, Darko, Zenko Sever, Anita, Zoričić, Ivan   +9 more
core   +7 more sources

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Journal of Pharmacological Sciences, 2008
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this ...
Robert Klicek, Marko Sever, Bozo Radic, Domagoj Drmic, Ivan Kocman, Ivan Zoricic, Tihomir Vuksic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Hrvoje Vrcic, Luka Brcic, Alenka Boban Blagaic, Marijana Coric, Iva Brcic, Dinko Stancic Rokotov, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +4 more sources

Stable Isotope Labeling-Based Nontargeted Strategy for Characterization of the In Vitro Metabolic Profile of a Novel Doping BPC-157 in Doping Control by UHPLC-HRMS. [PDF]

Molecules, 2023
Traditional strategies for the metabolic profiling of doping are limited by the unpredictable metabolic pathways and the numerous proportions of background and chemical noise that lead to inadequate metabolism knowledge, thereby affecting the selection ...
Tian T, Jing J, Li Y, Wang Y, Deng X, Shan Y.   +5 more
europepmc   +2 more sources

Concerning BPC-157, a natural pentadecapeptide, that acts as a cytoprotectant and is believed to protect the gastro-intestinal tract (GIT). [PDF]

Inflammopharmacology
This article discusses the lengthy review by Pedrag Sikiric and twenty one (21) co-authors in Inflammopharmacology (2024) 32:3119–3161.
Whitehouse M.
europepmc   +2 more sources

Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats. [PDF]

Pharmaceutics
Background: This is a novel rat study using native peptide therapy, focused on reversing quadriceps muscle-to-bone detachment to reattachment and stable gastric pentadecapeptide BPC 157 per-oral therapy for shared muscle healing and function restoration.
Matek D, Matek I, Staresinic E, Japjec M, Bojanic I, Boban Blagaic A, Beketic Oreskovic L, Oreskovic I, Ziger T, Novinscak T, Krezic I, Strbe S, Drinkovic M, Brkic F, Popic J, Skrtic A, Seiwerth S, Staresinic M, Sikiric P, Brizic I.   +19 more
europepmc   +2 more sources

Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy. [PDF]

Pharmaceuticals (Basel)
To better address the challenge of corneal ulcer healing, with already available standard agents, and those recently introduced, such as stable gastric pentadecapeptide BPC 157, we introduced a novel conceptual framework—the “triad” of corneal ulcer ...
Masnec S, Kokot A, Kralj T, Zlatar M, Loncaric K, Sablic M, Kalauz M, Beslic I, Oroz K, Mrvelj B, Beketic Oreskovic L, Oreskovic I, Strbe S, Staresinic B, Slivsek G, Boban Blagaic A, Seiwerth S, Skrtic A, Sikiric P.   +18 more
europepmc   +2 more sources

Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME [PDF]

, 2017
AIM: To counteract/reveal celecoxib-induced toxicity and NO system involvement. ----- METHODS: Celecoxib (1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157 (known to inhibit these lesions, 10 μg/kg, 10 ng ...
Bauk, Lara, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Luetić, Krešimir, Seiwerth, Sven, Sever, Marko, Sikirić, Predrag, Zenko Sever, Anita, Šuran, Jelena   +9 more
core   +3 more sources

Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. [PDF]

Biomedicines, 2022
In heart disturbances, stable gastric pentadecapeptide BPC 157 especial therapy effects combine the therapy of myocardial infarction, heart failure, pulmonary hypertension arrhythmias, and thrombosis prevention and reversal.
Sikiric P, Udovicic M, Barisic I, Balenovic D, Zivanovic Posilovic G, Strinic D, Uzun S, Sikiric S, Krezic I, Zizek H, Yago H, Gojkovic S, Smoday IM, Kalogjera L, Vranes H, Sola M, Strbe S, Koprivanac A, Premuzic Mestrovic I, Mestrovic T, Pavic P, Skrtic A, Blagaic AB, Lovric Bencic M, Seiwerth S.   +24 more
europepmc   +2 more sources