Results 41 to 50 of about 830 (135)

Stable gastric pentadecapeptide BPC 157

Journal of physiology and pharmacology, 2009
Considering peptidergic drugs, many cytokines, enzymes, clotting factors registered for the use as therapeutic agents in specific conditions, they are mainly given by injection, only occasionally by other routes. Also, to ascertain delivery and activity, they use different carriers, peptide+carrier complex may provide significant methodology/activity ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko   +3 more
  +7 more sources

Molecular effects of stable gastric pentadecapeptide BPC 157 on psoriasis

Liječnički vjesnik, 2023
Psoriasis is a chronic, relapsing, immune-mediated skin disease. Etiopathogeniesis of psoriasis includes pro-inflammatory cytokines such as: TNF-alpha, IL-12, IL-17, IL-23 etc.
Hrvoje Vraneš, Luka Kalogjera, Ivan Maria Smoday   +2 more
doaj   +1 more source

Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. [PDF]

Curr Rev Musculoskelet Med
McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM.   +4 more
europepmc   +3 more sources

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

Journal of Orthopaedic Surgery and Research, 2019
Background We focused on the therapeutic effects of the stable gastric pentadecapeptide BPC 157 in spinal cord injury using a rat model. BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel ...
Darko Perovic, Danijela Kolenc, Vide Bilic, Nenad Somun, Domagoj Drmic, Esmat Elabjer, Gojko Buljat, Sven Seiwerth, Predrag Sikiric   +8 more
doaj   +1 more source

Stable Gastric Pentadecapeptide BPC 157 Therapy for Monocrotaline-Induced Pulmonary Hypertension in Rats Leads to Prevention and Reversal

Biomedicines, 2021
Background. Monocrotaline selectively injures the lung’s vascular endothelium and induces pulmonary arterial hypertension. The stable gastric pentadecapeptide BPC 157 acts as a prototype cytoprotective agent that maintains endothelium, and its ...
Mario Udovicic, Marko Sever, Lovro Kavur, Kristina Loncaric, Ivan Barisic, Diana Balenovic, Gordana Zivanovic Posilovic, Dean Strinic, Sandra Uzun, Lovorka Batelja Vuletic, Suncana Sikiric, Anita Skrtic, Domagoj Drmic, Alenka Boban Blagaic, Martina Lovric Bencic, Sven Seiwerth, Predrag Sikiric   +16 more
doaj   +1 more source

Pentadecapeptide BPC 157 and rat osteoarthritis

The FASEB Journal, 2013
Rat osteoarthritis (transected anterior cruciate and medial collateral ligament, medial meniscectomy) exhibited large cartilage destruction, still preserved bone (4 weeks), proximal tibia (cartilage and bone) totally destructed (8 and 12 weeks), and severely impaired knee function.
Predrag Sikiric, Zoran Krstonijevic, Marko Sever, Nermin Lojo, Domagoj Drmic, Anita Zenko, Luka Brcic, Ivan Zoricic, Zarko Rasic, Rudolf Rucman, Sven Seiwerth   +10 more
openaire   +1 more source

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Journal of Pharmacological Sciences, 2008
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this ...
Robert Klicek, Marko Sever, Bozo Radic, Domagoj Drmic, Ivan Kocman, Ivan Zoricic, Tihomir Vuksic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Hrvoje Vrcic, Luka Brcic, Alenka Boban Blagaic, Marijana Coric, Iva Brcic, Dinko Stancic Rokotov, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source

Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157

Biomedicines, 2021
We redefined Robert’s prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar to that which occurs when major central or peripheral veins are occluded
Slaven Gojkovic, Ivan Krezic, Hrvoje Vranes, Helena Zizek, Domagoj Drmic, Lovorka Batelja Vuletic, Marija Milavic, Suncana Sikiric, Irma Stilinovic, Paris Simeon, Mario Knezevic, Toni Kolak, Marijan Tepes, Karol Simonji, Sanja Strbe, Nora Nikolac Gabaj, Ivan Barisic, Emma Grace Oreskovic, Eva Lovric, Antonio Kokot, Anita Skrtic, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric   +23 more
doaj   +1 more source

Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension

Biomedicines, 2021
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta.
Mario Knezevic, Slaven Gojkovic, Ivan Krezic, Helena Zizek, Dominik Malekinusic, Borna Vrdoljak, Hrvoje Vranes, Tamara Knezevic, Ivan Barisic, Katarina Horvat Pavlov, Domagoj Drmic, Miro Staroveski, Antonija Djuzel, Zoran Rajkovic, Toni Kolak, Ivica Kocman, Eva Lovric, Marija Milavic, Suncana Sikiric, Ante Tvrdeic, Leonardo Patrlj, Sanja Strbe, Antonio Kokot, Alenka Boban Blagaic, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +26 more
doaj   +1 more source

The effects of pentadecapeptide BPC 157 on the healing of the incisional skin wound in rats

Liječnički vjesnik, 2023
Healing of the wounds is accomplished by: the resolution of vessel constriction, the primary platelet plug formation, the fibrin mesh which acts to stabilize the platelet plug and finally resolution of the clot.
Luka Kalogjera, Ivan Maria Smoday
doaj   +1 more source