Results 21 to 30 of about 261,882 (142)

Stable gastric pentadecapeptide BPC 157

Journal of physiology and pharmacology, 2009
Considering peptidergic drugs, many cytokines, enzymes, clotting factors registered for the use as therapeutic agents in specific conditions, they are mainly given by injection, only occasionally by other routes. Also, to ascertain delivery and activity, they use different carriers, peptide+carrier complex may provide significant methodology/activity ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko   +3 more
openaire   +3 more sources

Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

Pharmaceuticals, 2023
Even before behavioral disturbances, neuroleptics, amphetamine, and domperidone application rapidly emerged severe occlusion/occlusion-like syndrome, shared innate vascular and multiorgan failure in rats, comparable to occlusion/occlusion-like syndrome ...
Sanja Strbe, Ivan Maria Smoday, Ivan Krezic, Luka Kalogjera, Vlasta Vukovic, Helena Zizek, Slaven Gojkovic, Hrvoje Vranes, Ivan Barisic, Suncana Sikiric, Marijan Tepes, Katarina Oroz, Filip Brkic, Martin Drinkovic, Lidija Beketic Oreskovic, Jelena Popic, Alenka Boban Blagaic, Anita Skrtic, Mario Staresinic, Sven Seiwerth, Predrag Sikiric   +20 more
doaj   +1 more source

Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy

Current Issues in Molecular Biology, 2022
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the ...
Darko Perovic, Marija Milavic, Stjepan Dokuzovic, Ivan Krezic, Slaven Gojkovic, Hrvoje Vranes, Igor Bebek, Vide Bilic, Nenad Somun, Ivan Brizic, Ivan Skorak, Klaudija Hriberski, Suncana Sikiric, Eva Lovric, Sanja Strbe, Milovan Kubat, Alenka Boban Blagaic, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source

BPC 157 as Potential Treatment for COVID-19

Medical Hypotheses, 2022
The emergence of coronavirus disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. COVID-19 is largely seen as a thrombotic and vascular disease targeting endothelial cells (ECs) throughout the body that can provoke the breakdown of central vascular functions.
openaire   +2 more sources

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

Journal of Orthopaedic Surgery and Research, 2019
Background We focused on the therapeutic effects of the stable gastric pentadecapeptide BPC 157 in spinal cord injury using a rat model. BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel ...
Darko Perovic, Danijela Kolenc, Vide Bilic, Nenad Somun, Domagoj Drmic, Esmat Elabjer, Gojko Buljat, Sven Seiwerth, Predrag Sikiric   +8 more
doaj   +1 more source

Stable Gastric Pentadecapeptide BPC 157 Therapy for Monocrotaline-Induced Pulmonary Hypertension in Rats Leads to Prevention and Reversal

Biomedicines, 2021
Background. Monocrotaline selectively injures the lung’s vascular endothelium and induces pulmonary arterial hypertension. The stable gastric pentadecapeptide BPC 157 acts as a prototype cytoprotective agent that maintains endothelium, and its ...
Mario Udovicic, Marko Sever, Lovro Kavur, Kristina Loncaric, Ivan Barisic, Diana Balenovic, Gordana Zivanovic Posilovic, Dean Strinic, Sandra Uzun, Lovorka Batelja Vuletic, Suncana Sikiric, Anita Skrtic, Domagoj Drmic, Alenka Boban Blagaic, Martina Lovric Bencic, Sven Seiwerth, Predrag Sikiric   +16 more
doaj   +1 more source

Hepatoprotective effects of BPC-157 - paracetamol overdose

Liječnički vjesnik, 2023
Paracetamol, also known as acetaminophen, is a widely used medication to treat pain and fever. As it’s one of the over-the-counter medications, it’s easily accessible to everyone. Its mechanism of action is the inhibition of prostaglandin synthesis in the CNS to reduce hyperalgesia. It also influences the thermoregulatory center in the hypothalamus and
Sara Burić, Hrvoje Vraneš, Vlasta Vuković   +2 more
openaire   +2 more sources

Physiological and Immunological Status of Adult Honeybees (Apis mellifera) Fed Sugar Syrup Supplemented with Pentadecapeptide BPC 157

Biology, 2021
Various factors contribute to a decline in diversity and number of bees. Here, an integrated approach in experimental BPC 157 therapy was implemented, combining laboratory-controlled and field study results.
Ivana Tlak Gajger, Maja Ivana Smodiš Škerl, Petra Šoštarić, Jelena Šuran, Predrag Sikirić, Josipa Vlainić   +5 more
doaj   +1 more source

Pentadecapeptide BPC 157 therapy in bile duct ligated (bdl) rats [PDF]

, 2019
Pentadecapeptide BPC 157 demonstrates beneficial healing and anti-inflammatory effects on gastrointestinal and many extra - gastrointestinal tissues. Bile duct ligation causes inflammation and fibrotic changes in the liver. We wanted to explore effect of
Antunović, Marko, Fry, Josh, Orešković, Emma, Peraić, Pavla, Belamarić, Marko, Malekinušić, Dominik, Krezić, Ivan   +6 more
core   +3 more sources

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Journal of Pharmacological Sciences, 2008
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this ...
Robert Klicek, Marko Sever, Bozo Radic, Domagoj Drmic, Ivan Kocman, Ivan Zoricic, Tihomir Vuksic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Hrvoje Vrcic, Luka Brcic, Alenka Boban Blagaic, Marijana Coric, Iva Brcic, Dinko Stancic Rokotov, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source