Results 21 to 30 of about 44,634 (185)

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

Journal of Pharmacological Sciences, 2017
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepezil ...
Kouki Makitani, Shota Nakagawa, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume   +4 more
doaj   +1 more source

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. [PDF]

PLoS ONE, 2015
Cerebral arterial myogenic and autoregulatory responses are impaired in Fawn Hooded hypertensive (FHH) rats. Cerebral autoregulatory responses are restored in the congenic rat strain in which a segment of chromosome 1 from the Brown Norway (BN) rat was ...
Md Abdul Hye Khan, Amit Sharma, Kevin R Rarick, Richard J Roman, David R Harder, John D Imig   +5 more
doaj   +1 more source

Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist Peptide from Ranid Frogs

The Scientific World Journal, 2014
The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions
Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw   +8 more
doaj   +1 more source

Effects of bradykinin on the survival of multiterritory perforator flaps in rats

World Journal of Surgical Oncology, 2019
Background Bradykinin, a vasoactive peptide, has many biological functions. For example, it accelerates angiogenesis. Thus, we studied the effects of bradykinin on the survival of perforator flaps.
Jieke Wang, Encheng Ji, Chen Lin, Long Wang, Li Dai, Weiyang Gao   +5 more
doaj   +1 more source

At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis

Advanced Healthcare Materials, EarlyView.
Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang, Chayla L. Reeves, Mehrnoosh Moghaddar, Kate E. Fox, Aaron Elbourne, Amy Gelmi   +5 more
wiley   +1 more source

DETERMINATION OF RELAXANT EFFECT OF ROPIVACAINE AGAINST ACETYLCHOLINE AND BRADYKININ INDUCED AIRWAY CONTRACTION OF GUINEA PIGS

Pakistan Armed Forces Medical Journal, 2020
Objective: To study the relaxant effect of ropivacaine against acetylcholine and bradykinin induced airway contraction of isolated tracheal tissue of guinea pig in vitro. Study Design: Laboratory based experimental study.
Fatima Qasim Malik, Bushra Tayyaba Khan, Mahjabeen Sharif   +2 more
doaj  

Bradykinin release avoids high molecular weight kininogen endocytosis. [PDF]

PLoS ONE, 2015
Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis.
Igor Z Damasceno, Katia R B Melo, Fabio D Nascimento, Daianne S P Souza, Mariana S Araujo, Sinval E G Souza, Misako U Sampaio, Helena B Nader, Ivarne L S Tersariol, Guacyara Motta   +9 more
doaj   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep

Journal of Parasitology Research, 2012
Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum
Andrew R. Williams
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source