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Recent developments in the understanding of bradykinin receptors
Life Sciences, 1992The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growth, and leukocyte activation have ...
R M, Burch, D J, Kyle
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Advances in the Development of Bradykinin Receptor Ligands
Current Topics in Medicinal Chemistry, 2006Kinins are blood-derived local-acting peptides that elicit specific cellular effects via the stimulation of two related G protein coupled receptors. While the B(2)receptor subtype, constitutively expressed in various tissues, is believed to mediate most of the physiological actions of kinins in healthy conditions, the B(1) receptor, highly regulated ...
Jean-Philippe, Fortin +1 more
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Differential Contribution of Bradykinin Receptors in Angiogenesis
2000Bradykinin (BK) contributes to the inflammatory response inducing vasodilation of postcapillary venules and has been demonstrated to induce neovascular growth in subcutaneous rat sponges. In this study the ability of BK to stimulate cell growth and migration in cultured endothelium from coronary postcapillary venules (CVEC) has been investigated.
Morbidelli, Lucia +5 more
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The Bradykinin B2-Receptor in Human Decidua
Seminars in Thrombosis and Hemostasis, 1999Bacterial infection of the amniotic cavity is one of the most frequent causes of preterm delivery. Bacterial products activate a network of autocrine and paracrine mediators in fetal membranes and decidua, with prostaglandins finally inducing contractions of the myometrium. Bradykinin and its B2-receptor (B2R) seem to be part of this network.
P, Buchinger, J, Rehbock
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Bradykinin receptor types and B2 subtypes
Life Sciences, 1994Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely used B2 preparations which have shown marked differences in their ...
D, Regoli +6 more
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Activation of B2 bradykinin receptors by neurotensin
Cellular Signalling, 2003Many previous reports suggested that relatively high concentrations of neurotensin were required to exert its effects on neurotransmitter secretion. The neurotensin binding sites, which recognize high concentrations of neurotensin, were characterized in rat pheochromocytoma (PC12) cells. When PC12 cells were treated with neurotensin, [3H]norepinephrine
Park, TJ, Kim, KT
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Bradykinin receptor ligands: therapeutic perspectives
Nature Reviews Drug Discovery, 2004Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-acting peptides that have broad effects mediated by two related G-protein-coupled receptors termed the bradykinin receptors. The endogenous kallikrein-kinin system controls blood circulation and kidney function, and promotes inflammation and pain in pathological ...
François, Marceau, Domenico, Regoli
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Expression and function of bradykinin receptors in microglia
Life Sciences, 2003Expression of bradykinin (BK) receptors and their cellular function were investigated in microglia. Microglial cells were isolated from mixed cultures of cerebrocortical cells from postnatal day 3 Wistar rats. Reverse transcription-PCR (RT-PCR) showed that rat primary microglia express mRNAs for the type 2 bradykinin (B(2)) receptor subtype but not the
Mami, Noda +6 more
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Intracellular and nuclear bradykinin B2 receptors
European Journal of Pharmacology, 2014Bradykinin is a vasoactive peptide that participates in numerous inflammatory processes, vasodilation, and cell growth/survival; it mainly acts through two receptor subtypes, bradykinin B1 and bradykinin B2 receptors, which are G protein-coupled receptor (GPCR) family members.
Masaoki Takano, Shogo Matsuyama
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Characterization of bradykinin receptors in peripheral organs
Canadian Journal of Physiology and Pharmacology, 1991Bradykinin (BK) and related kinins are potent stimulants of the rabbit jugular vein, the hamster urinary bladder, and the guinea pig trachea. The characterization of kinin receptors in these tissues was made with agonists and antagonists. Results obtained with agonists indicate that bradykinin and kallidin are much more active than des-Arg9-BK and ...
N E, Rhaleb +4 more
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