Results 111 to 120 of about 174,356 (352)

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling [PDF]

, 2005
Kavita V Bhatt, Laurie S. Spofford, Gazelle Aram, Meghan E. McMullen, Kevin Pumiglia, Andrew E. Aplin   +5 more
openalex   +1 more source

Table S2 from Fibronectin Contributes to a BRAF Inhibitor–driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2

, 2023
Hannah M. Hicks, Nikita Pozdeyev, Sharon B. Sams, Umarani Pugazhenthi, Elise S. Bales, Marie‐Claude Hofmann, Logan R. McKenna, Rebecca E. Schweppe   +7 more
openalex   +1 more source

Independent Prognostic Significance of Perforation in Colorectal Cancer: Insights From a Propensity Score‐Matched Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
Perforated colorectal cancer (PCC) is considered to have a poor prognosis; however, it remains unclear whether this is attributable to perforation itself or to perforation‐related clinicopathological factors. In this study, we analyzed prognosis using propensity score matching with perforation‐related factors and demonstrated that perforation is an ...
Yoshiaki Fujii, Shuhei Ueno, Yoshinaga Aoyama, Hiroyuki Imafuji, Takahisa Hirokawa, Hirotaka Miyai, Masahiro Kimura, Kenji Kobayashi, Shuji Takiguchi   +8 more
wiley   +1 more source

SLPI as a dedifferentiation biomarker in BRAFV600E-mutant papillary thyroid cancer

Endocrine Connections
The BRAFV600E mutation drives papillary thyroid carcinoma (PTC) progression and therapy resistance, yet its downstream effectors remain incompletely characterized.
Wei Luo, Xin Ji, Xiang-Yu Tan, Yu-Ting Li, Zhi-Qiang Zhang, Chui-Mian Zeng   +5 more
doaj   +1 more source

Limits of Dideoxysequencing in the Detection of Somatic Mutations in Gastrointestinal Stromal Tumors

Acta Medica Martiniana, 2015
Detection of mutations in cancer is particularly important in terms of proper treatment and targeted therapy. The aim of this study was the comparison of two methods: allele-specific PCR (AS-PCR) and dideoxysequencing applied for the identification of ...
Jasek K, Buzalkova V, Szepe P, Plank L, Lasabova Z   +4 more
doaj   +1 more source

Role of tyrosine-kinase inhibitor selectivity in development of adverse effects during treatment of chronic myeloid leukemia

Клиническая онкогематология, 2014
This review focuses on association between the selectivity of Bcr-Abl kinase inhibitors and the spectrum of their adverse effects during treatment of patients with chronic myeloid leukemia.
A. A. Zeifman, E. Yu. Chelysheva, A. G. Tukrina, G. G. Chilov   +3 more
doaj   +1 more source

Targeting BRAF V600E in metastatic colorectal cancer: where are we today? [PDF]

, 2022
Rodrigo Motta, Veronica Arnao Labajos, Sophia Lozano Ballena, Carlos Aliaga Macha, Miguel J. Sotelo, Cristian Pacheco Roman, Paola Montenegro Beltran, Alejandro Figueroa Torrejon   +7 more
openalex   +1 more source

Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis evaluated the role of primary tumor resection (PTR) in asymptomatic patients with unresectable metastatic colorectal cancer. Across 17 eligible studies including 9317 patients, PTR did not improve overall or progression‐free survival compared with chemotherapy alone.
Junpei Takashima, Hirotoshi Kobayashi, Daisuke Fujimoto, Fumihiko Miura   +3 more
wiley   +1 more source