Results 91 to 100 of about 119,295 (311)

Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways

Open Medicine, 2020
In 2010, serrated polyps (SP) of the colon have been included in the WHO classification of digestive tumors. Since then a large corpus of evidence focusing on these lesions are available in the literature.
Sacco Michele, De Palma Fatima Domenica Elisa, Guadagno Elia, Giglio Mariano Cesare, Peltrini Roberto, Marra Ester, Manfreda Andrea, Amendola Alfonso, Cassese Gianluca, Dinuzzi Vincenza Paola, Pegoraro Francesca, Tropeano Francesca Paola, Luglio Gaetano, De Palma Giovanni Domenico   +13 more
doaj   +1 more source

Microarray expression profiling in melanoma reveals a BRAF mutation signature [PDF]

, 2004
We have used microarray gene expression pro. ling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines.
Schmidt, C, Walker, Graeme J., Ellem, KAO, Meltzer, Paul S., Laura Yudt, Johansson, Peter, Taylor, J, Michael GE O'Rourke, Ringnér, Markus, Yudt, Laura, Hersey, Peter, Glen M Boyle, Sarah-Jane Cozzi, O'Rourke, MGE, Pollock, PM, Harper, U, Cozzi, SJ, Hansen, Katherine, Hayward, NK, Cozzi, Sarah-Jane, Chris Schmidt, Harper, Ursula, Ellem, Kay A. O., Paul Meltzer, Peter Hersey, Stark, Mitchell, Peter G Parsons, Parsons, Peter G., Nicholas K Hayward, Meltzer, Paul, Mitchell Stark, Graeme J Walker, Boyle, Glen M., Hansen, K, Jennifer Taylor, Katherine Hansen, Meltzer, P, Schmidt, Chris, Sandra Pavey, Stark, M, Peter Johansson, Parsons, PG, Packer, Leisl, O'Rourke, Michael, Taylor, Jennifer, Ursula Harper, O'Rourke, Michael G. E., Markus Ringnér, Pamela M Pollock, Yudt, L, Pavey, Sandra, Packer, L, Pollock, Pamela M., Hersey, P, Kay AO Ellem, Ringnér, Markus,, Boyle, GM, Ellem, Kay, Leisl Packer, Hayward, Nicholas K., Pavey, S, Walker, GJ   +61 more
core   +1 more source

BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer

, 2021
CONTEXT: How lymph node metastasis (LNM)-associated mortality risk is affected by BRAF V600E in papillary thyroid cancer (PTC) remains undefined. OBJECTIVE: To study whether BRAF V600E affected LNM-associated mortality in PTC.
Liu, Rengyun, Mian, Caterina, Fugazzola, Laura, Czarniecka, Agnieszka, Puxeddu, Efisio, Zhu, Guangwu, Tao, Yubing, Viola, David, Wang, Fei, Colombo, Carla, Jarzab, Barbara, Shen, Xiaopei, Elisei, Rossella, Lam, Alfred K, et al.   +14 more
core   +1 more source

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

BRAF inhibitor therapy for melanoma, thyroid and colorectal cancers : development of resistance and future prospects

, 2014
BRAF is a major oncoprotein and oncogenic mutations in BRAF are found in a significant number of cancers, including melanoma, thyroid cancer, colorectal cancer and others. Consequently, BRAF inhibitors have been developed as treatment options for cancers
Salajegheh, Ali, Rahman, Md Atiqur, Lam, Alfred King-yin, Smith, Robert A.   +3 more
core   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

GENETIC POLYMORPHISM OF RETROPERITONEAL MYXOID LIPOSARCOMA

Сибирский онкологический журнал, 2020
Objective: to detect new molecular genetic markers and therapeutic targets in retroperitoneal myxoid liposarcoma.Material and Methods. DNA samples isolated from tumor tissue and obtained from formalinfixed paraffin-embedded (FFPE) slides were used.
A. Yu. Volkov, V. M. Safronova, S. N. Nered, L. N. Lyubchenko, I. S. Stilidi   +4 more
doaj   +1 more source

Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated [PDF]

, 2020
Background: Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. Methods: DNA and RNA mutation status was
Chouchane, Lotfi, De Giorgi, Valeria, Liu, Wei, James, Nicola, Temanni, Ramzi, Mattei, Valentina, Tomei, Sara, Al Hashmi, Muna, Bedognetti, Davide, Chouchane, Aouatef, Silcock, Lee, Seliger, Barbara, Sastry, Konduru S, Mathew, Rebecca, Murtas, Daniela, Wang, Ena, Marincola, Francesco M   +16 more
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Prognostic value of BRAF mutations in localized cutaneous melanoma

, 2014
BACKGROUND: \ud BRAF mutations are frequent in melanoma but their prognostic significance remains unclear.\ud OBJECTIVE: \ud We sought to further evaluate the prognostic value of BRAF mutations in localized cutaneous melanoma.\ud METHODS: \ud We ...
Requena, Celia, Hacker, Elke, Guillen, Carlos, Hayward, Nicholas K, Nagore, Eduardo, Traves, Victor, Whiteman, David C   +6 more
core   +1 more source