Results 121 to 130 of about 198,722 (342)
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma +9 more
wiley +1 more source
International Journal of General Medicine, 2021 Linjue Shangguan,1,* Peipei Zhang,1 Shengwei Fang,1 Kaili Xiang,1 Yawen Geng,1 Dingcun Luo,2,* Chunlei Zhao1,* 1Department of Nuclear Medicine, Hangzhou Cancer Hospital, Hangzhou, 310002, People’s Republic of China; 2Department of Tumor ...
Shangguan L +6 more
doaj
Annals of Gastroenterological Surgery, EarlyView.Perforated colorectal cancer (PCC) is considered to have a poor prognosis; however, it remains unclear whether this is attributable to perforation itself or to perforation‐related clinicopathological factors. In this study, we analyzed prognosis using propensity score matching with perforation‐related factors and demonstrated that perforation is an ...
Yoshiaki Fujii +8 more
wiley +1 more source
NRAS-driven melanoma: A RAF can hide another
Molecular & Cellular Oncology, 2017 Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain ...
Sabine Druillennec +2 more
doaj +1 more source
Frontiers in Pigment Cell and Melanoma Research
, 2018 We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca +26 more
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.This systematic review and meta‐analysis evaluated the role of primary tumor resection (PTR) in asymptomatic patients with unresectable metastatic colorectal cancer. Across 17 eligible studies including 9317 patients, PTR did not improve overall or progression‐free survival compared with chemotherapy alone.
Junpei Takashima +3 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.In this retrospective cohort of 3487 patients with CRC, history of CCY was associated with significantly worse prognosis in patients with proximal CRC but not in those with distal CRC. This differential prognostic impact showed a statistically significant interaction between tumor location and history of CCY and remained robust after PSM.
Masashi Tsunematsu +9 more
wiley +1 more source
The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma. [PDF]
, 2018 Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules.
Burlingame, Alma +18 more
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background Determining whether to resect disappearing liver metastases (DLMs) after chemotherapy for colorectal liver metastases (CRLMs) remains challenging. Methods Patients who underwent hepatectomy after systemic chemotherapy for initially unresectable CRLMs were reviewed. True complete response (CR) was defined as either resected DLMs with
Taihei Soma +9 more
wiley +1 more source