Results 221 to 230 of about 119,295 (311)

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source

Dabrafenib and trametinib-induced hyperglycemia with decreased insulin secretion in a patient with lung adenocarcinoma. [PDF]

JCEM Case Rep
Nagano K, Suzuki M, Morikawa S, Watanabe R, Ohara T, Hara K.   +5 more
europepmc   +1 more source

Incidence, severity and potential pathomechanism of immune‐related pruritus in melanoma patients undergoing immune checkpoint inhibitor therapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Pruritus is a frequent cutaneous immune‐related adverse event (irAE) associated with immune checkpoint inhibitors (ICI), impacting patients' quality of life. This study investigates the incidence, severity and management of pruritus in melanoma patients treated with ICI.
Andrea Roggo, Nikolina Ivanovic, Patrick Turko, Lukas Kraehenbuehl, Mitchell Levesque, Reinhard Dummer, Barbara Meier‐Schiesser   +6 more
wiley   +1 more source

ERK1/2 Inhibitor Ulixertinib in Pan-cancer Patients with BRAF Fusions or Non-V600E/K Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1L. [PDF]

Clin Cancer Res
Subbiah V, Zhao F, Kudchadkar RR, Sullivan RJ, Chen HX, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Sundaresan TK, Conley BA, Tricoli JV, Arteaga CL, Wright JJ, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.   +20 more
europepmc   +1 more source

Practical management of BRAF inhibitors in glioma: toxicity and resistance. [PDF]

CNS Oncol
Bazer D, Ayanlaja AA, Schreck KC.
europepmc   +1 more source

Contemporary Multimodal Management of Cutaneous Malignancies: Surgery, Radiotherapy, Systemic Therapy, Molecular Targeting and Immunotherapy. [PDF]

Cancers (Basel)
Kowalczyk D, Jaworek J, Ciborek A, Kolodziejski PA, Pruszyńska-Oszmałek E, Krauss H.   +5 more
europepmc   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Therapeutic Resistance in Melanoma: Molecular Mechanisms and Emerging Pharmaceutical Strategies. [PDF]

Pharmaceuticals (Basel)
Moussallem N, Awada A, El Darzi R, Tarhini A, Khaled A, Ashy C, Nasr W, El Masri A, Saad G, Itani M, Rizkallah J, Charbel N, Hatahet Z, Saade D, Abou Rahal J, Kreidieh F.   +15 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Integrated NGS and ddPCR analysis of RAS/RAF mutations in metastatic colorectal cancer among Kazakhstani patients: a pilot study. [PDF]

Front Med (Lausanne)
Kulmambetova G, Tarlykov P, Auganova D, Gusmaulemova A, Kurentay B, Mamlin M.   +5 more
europepmc   +1 more source