Results 91 to 100 of about 102,854 (205)

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +2 more sources

A multi-center cross-sectional investigation of BRAF V600E mutation in Ameloblastoma [PDF]

PeerJ
Background B-Raf proto-oncogene, serine/threonine kinase (BRAF) V600E mutation stands as a pivotal genetic alteration strongly associated with several neoplasms and contributes significantly to their pathogenesis as well as potential targeted treatment ...
Khin Mya Tun, Puangwan Lapthanasupkul, Anak Iamaroon, Wacharaporn Thosaporn, Poramaporn Klanrit, Sompid Kintarak, Siwaporn Thanasan, Natchalee Srimaneekarn, Nakarin Kitkumthorn   +8 more
doaj   +2 more sources

CTLA-4 and PD-1 ligand gene expression in epithelial thyroid cancers [PDF]

, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80 and CD86 was evaluated at mRNA level in 94 patients affected ...
Antonelli, Alessandro, Arcieri, Stefano, Baldini, Enke, Barollo, Susi, Carbotta, Giovanni, Catania, Antonio, Fallahi, Poupak, Mian, Caterina, Monti, Massimo, Palmieri, Andrea, Pironi, Daniele, Sorrenti, Salvatore, Tartaglia, Francesco, Tuccilli, Chiara, Ulisse, Salvatore, Vergine, Massimo   +15 more
core   +3 more sources

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. [PDF]

, 2018
Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior.
Camacho, FM, Dao, DQ, Kandalam, SM, Krencik, R, Rauen, KA, Tom, C, Ullian, EM, Weiss, LA, Wu, ZY, Yeh, E, Zhang, W   +10 more
core  

Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032

Journal of Translational Medicine, 2010
Activating mutations in BRAF kinase are common in melanomas. Clinical trials with PLX4032, the mutant-BRAF inhibitor, show promising preliminary results in patients selected for the presence of V600E mutation.
Bacchiocchi Antonella, Cheng Elaine, Ariyan Stephan, Pavlick Anna C, Sznol Mario, Rubinstein Jill C, Kluger Harriet M, Narayan Deepak, Halaban Ruth   +8 more
doaj   +1 more source

Can mutation abundance assess the biological behavior of BRAF V600E-positive papillary thyroid carcinoma?

Journal of Translational Medicine
Background BRAF V600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF V600E mutation status and abundance and the biological behavior of PTC is unclear.
Yeqin Ni, Ping Song, Xiangfeng Lin, Jingjing Shi, Qian Shi, Yuanhui Li, Siyu Zhu, Tianhan Zhou, Yanping Xun, Shirong Zhang, Xingchang Ren, Kaining Lu, Fan Wu, Wei Wang, Pan Zhao, Rongjing Zhou, Wenhua Zhang, Dandan Li, Jiaoping Zhang, Chuanghua Chen, Linlin Mao, Li Zhou, Gang Pan, You Peng, Yunxian Yu, Yuying Chen, Rong Ni, Guhan Luo, Yu Zhang, Jugao Fang, Haitao Zheng, Dingcun Luo   +31 more
doaj   +1 more source

BRAF mutations in acute leukemias [PDF]

Leukemia, 2003
J W, Lee, Y H, Soung, W S, Park, S Y, Kim, S W, Nam, W S, Min, J Y, Lee, N J, Yoo, S H, Lee   +8 more
openaire   +2 more sources

Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.

PLoS ONE, 2013
BackgroundThe aim of this study was to evaluate the proper indication of adjunctive BRAF(V600E) mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules.MethodsThis study included 518 nodules in 479 ...
Jieun Koh, Jong Rak Choi, Kyung Hwa Han, Eun-Kyung Kim, Jung Hyun Yoon, Hee Jung Moon, Jin Young Kwak   +6 more
doaj   +1 more source

Role of contrast-enhanced ultrasound with time-intensity curve analysis about thyroid nodule and parenchyma for differentiating BRAF V600E mutation status [PDF]

PeerJ
Background The BRAF V600E mutation was proven associated with papillary thyroid cancer (PTC) which has more aggressive behavior and could affect the outcome of PTC.
Zhipeng Hu, Rong Xue, Zhixi Liu, Liang Liu, Zheli Gong   +4 more
doaj   +2 more sources

BRAF V600E mutation in thyroid carcinoma: a large-scale study in Han Chinese population

World Journal of Surgical Oncology
Background The prevalence of genetic mutations in thyroid cancer varies significantly among different ethnic backgrounds. The present study aimed to investigate the clinical potential of BRAF V600E in a large group of homogenous Han Chinese patients ...
Rong Cong, Hui Ouyang, Di Zhou, Xinying Li, Fada Xia   +4 more
doaj   +1 more source