Results 21 to 30 of about 102,854 (205)

BRAF mutation in thyroid cancer [PDF]

Endocrine Related Cancer, 2005
Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon which novel approaches to the management of thyroid cancer can be developed. A recent important genetic finding in thyroid cancer is the oncogenic T1799A transversion mutation of BRAF (the gene for the B-type Raf kinase, BRAF). Since the initial report of this
openaire   +2 more sources

BRAF mutation is not predictive of long-term outcome in papillary thyroid carcinoma [PDF]

, 2015
The BRAF mutation occurs commonly in papillary thyroid carcinoma (PTC). Previous investigations of its utility to predict recurrence-free survival (RFS) and disease-specific survival (DSS) have reported conflicting results and its role remains unclear ...
Baranski, Thomas J, DeWees, Todd, El-Mofty, Samir, Grigsby, Perry W, Haughey, Bruce H, Henke, Lauren E, Ma, Changquing, Moley, Jeffrey F, Nussenbaum, Brian, Perkins, Stephanie M, Pfeifer, John D, Schwarz, Julie K   +11 more
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False-negative BRAF V600E mutation results on fine-needle aspiration cytology of papillary thyroid carcinoma

World Journal of Surgical Oncology, 2017
Background The BRAF V600E mutation is highly specific for papillary thyroid carcinoma (PTC). A test for this mutation can increase the diagnostic accuracy of fine-needle aspiration cytology (FNAC), but a considerably high false-negative rate for the BRAF
Se Hyun Paek, Byung Seup Kim, Kyung Ho Kang, Hee Sung Kim   +3 more
doaj   +1 more source

The Significance of TROP2 Expression in Predicting Mutations in Papillary Thyroid Carcinoma [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis.
Joon Seog Kong, Hyeon Jin Kim, Min-Jung Kim, Areumnuri Kim, Dalnim Lee, Kanghee Han, Sunhoo Park, Jae Soo Koh, Jae Kyung Myung   +8 more
doaj   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
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The Genomic Environment of BRAF Mutated and BRAF/PIK3CA Double Mutated Colorectal Cancers

Journal of Clinical Medicine, 2022
Background: Colorectal cancer represents the most prevalent gastrointestinal malignancy. Prognosis of metastatic disease has improved in recent years with the introduction of effective systemic therapies, but mean survival remains in the range of two to three years.
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Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis

Scientific Reports, 2017
To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto’s thyroiditis (HT).
Qin Zhang, Bo-Ji Liu, Wei-Wei Ren, Ya-Ping He, Xiao-Long Li, Chong-Ke Zhao, Yi-Feng Zhang, Wen-Wen Yue, Jia-Yi Zheng, Hui-Xiong Xu   +9 more
doaj   +1 more source

Frequency of BRAF V600E Mutation in the Mexican Population of Patients With Metastatic Melanoma

Journal of Global Oncology, 2017
Purpose: The BRAF V600E mutation has been described in melanomas occurring in the Caucasian, European, and Asian populations. However, in the Mexican population, the status and clinical significance of BRAF mutation has not been researched on a large ...
Erika Ruiz-Garcia, Juan A. Matus-Santos, Jorge Alberto Guadarrama-Orozco, Miguel Angel Alvarez-Avitia, Jose Luis Aguilar-Ponce, Edith Fernandez-Figueroa, Jessica Maldonado-Mendoza, Cesar Lopez-Camarillo, Laurence A. Marchat, Saul Lino-Silva, Mario Cuellar-Hubbe, Jamie de la Garza-Salazar, Abelardo Meneses-García, Horacio Astudillo-de la Vega, Hector Martinez-Said   +14 more
doaj   +1 more source

BRAF V600E Immunohistochemistry Predicts Prognosis of Patients with Cutaneous Melanoma in Thai population

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. The BRAF V600E mutation in the Thai population has been identified in a considerable percentage of people with cutaneous melanoma. The objectives of this study were to determine the prevalence of this mutation in cutaneous melanomas, conduct
Jiraroch Meevassana, MD, Kullawit Anothaisatapon, MD, Surawish Subbalekha, MD, Supitcha Kamolratanakul, MD, Tippawan Siritientong, RPh, PhD, Komkrit Ruangritchankul, MD, Pornthep Pungrasami, MD, Kevin J Hamill, PhD, Apichai Angsapatt, MD, Nakarin Kitkumthorn, DDS, PhD   +9 more
doaj   +1 more source

Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]

, 2019
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G, Wu, Wei, Zaman, Aubhishek   +2 more
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