Results 61 to 70 of about 102,854 (205)

Cancer3D: understanding cancer mutations through protein structures. [PDF]

, 2014
The new era of cancer genomics is providing us with extensive knowledge of mutations and other alterations in cancer. The Cancer3D database at http://www.cancer3d.org gives an open and user-friendly way to analyze cancer missense mutations in the context
Godzik, Adam, Hrabe, Thomas, Porta-Pardo, Eduard   +2 more
core   +1 more source

Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

Journal of Translational Medicine, 2017
Background Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy number variation of EZH2 and ...
Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo, Yan Kong   +15 more
doaj   +1 more source

TERT Promoter Mutations in Papillary Thyroid Microcarcinomas [PDF]

, 2015
Small papillary thyroid carcinomas have contributed to the worldwide increased incidence of differentiated thyroid cancer observed over the past decades.
Bruno, Rocco, Casadei, Gianpaolo, Ciarrocchi, Alessia, Costante, Giuseppe, de Biase, Dario, Durante, Cosimo, Eszlinger, Markus, Filetti, Sebastiano, Frasoldati, Andrea, Gandolfi, Greta, Gugnoni, Mila, Paschke, Ralf, Pession, Annalisa, Piana, Simonetta, Ragazzi, Moira, Sancisi, Valentina, Tallini, Giovanni, Torlontano, Massimo, Visani, Michela   +18 more
core   +1 more source

The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis.

PLoS ONE, 2012
BackgroundMutation of BRAF is a predominant event in cancers with poor prognosis such as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of mitogen activated protein kinase pathway which is essential for cell ...
Gholamreza Safaee Ardekani, Seyed Mehdi Jafarnejad, Larry Tan, Ardavan Saeedi, Gang Li   +4 more
doaj   +1 more source

The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid Cancer in a Chinese Population

International Journal of Endocrinology, 2022
Background. The BRAF V600E mutation is an important genetic event in papillary thyroid cancer (PTC). This study aimed to provide additional information regarding the association of the BRAF V600E mutation with PTC prognosis. Methods.
Ziheng Ye, Xiaotian Xia, Peipei Xu, Wenfei Liu, Shoufei Wang, Youben Fan, Minggao Guo   +6 more
doaj   +1 more source

MicroRNAs in melanoma development and resistance to target therapy [PDF]

, 2017
microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio, Ciliberto, Gennaro, Costantini, Susan, Croce, Carlo M, Fattore, Luigi, Malpicci, Debora, Mancini, Rita, Ruggiero, Ciro Francesco   +7 more
core   +1 more source

Clinical and Molecular Profiling of Colorectal Cancer: A Comprehensive Cohort Study of BRAF-Mutated Cases from a Tertiary Centre

Current Oncology
Introduction: Increasingly, identification of BRAF mutation in colorectal cancer is used to guide management and predict cancer behaviour. There is, however, still significant diversity within this cohort of patients, both in terms of clinical phenotype ...
Julia Freckelton, Justin Mencel, Iris Levink, Sheela Rao, Charlotte Fribbens, Paula Proszek, Damian Brooks, Xin Liu, David Cunningham, Ian Chau, Naureen Starling   +10 more
doaj   +1 more source

High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia

BMC Research Notes, 2022
Objective Thyroid cancer incidence has steadily increased in Indonesia. However, data on Kirsten rat sarcoma virus (KRAS) and EGFR mutations in thyroid cancer in Indonesia remain unavailable, except for BRAF-V600E, the most common BRAF gene mutation ...
Didik Setyo Heriyanto, Vincent Laiman, Nikko Vanda Limantara, Widyan Putra Anantawikrama, Fara Silvia Yuliani, Rita Cempaka, Sumadi Lukman Anwar   +6 more
doaj   +1 more source

BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas [PDF]

Frontiers in Oncology, 2018
Low-grade gliomas (LGG) are the most common central nervous system tumors in children. Prognosis depends on complete surgical resection. For patients not amenable of gross total resection (GTR) new approaches are needed. The BRAF mutation V600E is critical for the pathogenesis of pediatric gliomas and specific inhibitors of the mutated protein, such as
Francesca Del Bufalo, Giulia Ceglie, Antonella Cacchione, Iside Alessi, Giovanna Stefania Colafati, Andrea Carai, Francesca Diomedi-Camassei, Emmanuel De Billy, Emanuele Agolini, Angela Mastronuzzi, Franco Locatelli, Franco Locatelli   +11 more
openaire   +3 more sources

Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer

Biomedicines
The early identification of aggressive forms of cancer is of high importance in treating papillary thyroid cancer (PTC). Disease dissemination is a major factor influencing patient survival. Mutation status of BRAF oncogene, BRAF V600E, is proposed to be
Ivan Blazekovic, Ivan Samija, Josipa Perisa, Koraljka Gall Troselj, Tihana Regovic Dzombeta, Petra Radulovic, Matija Romic, Roko Granic, Ines Sisko Markos, Ana Frobe, Zvonko Kusic, Tomislav Jukic   +11 more
doaj   +1 more source