Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord [PDF]
, 1999 Steve Thompson +4 more
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Advanced Science, EarlyView.Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen +14 more
wiley +1 more source
Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice [PDF]
, 1997 Daniel J. Liebl +3 more
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Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity
Advanced Science, EarlyView.This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu +8 more
wiley +1 more source
Brain‐derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss [PDF]
, 1998 Hinrich Staecker +3 more
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RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]
, 2015 A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core +1 more source
Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy
Advanced Science, EarlyView.This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan +4 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2008 Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Nobuhisa Ueda, Yuki Kodama, Wakako Umene-Nakano, Jun NakamuraDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka ...
Atsuko Ikenouchi-Sugita +5 more
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Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number [PDF]
, 1999 Ann M. LeMaster +6 more
openalex +1 more source
Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]
, 2012 Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla +2 more
core +1 more source