Results 161 to 170 of about 244,575 (365)

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

Cell, 2013
Christopher N. Parkhurst, Guang Yang, I. Ninan, J. Savas, J. Yates, J. Lafaille, B. Hempstead, D. Littman, W. Gan   +8 more
semanticscholar   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes

Neuropsychiatric Disease and Treatment, 2008
Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Nobuhisa Ueda, Yuki Kodama, Wakako Umene-Nakano, Jun NakamuraDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka ...
Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Nobuhisa Ueda, Yuki Kodama, Wakako Umene-Nakano, Jun Nakamura   +5 more
doaj  

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Proceedings of the National Academy of Sciences of the United States of America, 1995
M. Korte, P. Carroll, Eckhard Wolf, G. Brem, H. Thoenen, T. Bonhoeffer   +5 more
semanticscholar   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]

, 2015
A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core   +1 more source

Impact of low dose nicotine on brain-derived neurotrophic factor after global hypoxia in newborn piglets

Journal of Perinatal Medicine
The aim of this study was to assess the effect of low-dose nicotine on the expression of brain-derived neurotrophic factor (BDNF) mRNA, its antisense alternative splice form brain-derived neurotrophic factor antisense (BDNF-AS), and its protein levels ...
Vølstad Karianne B., Melheim Maria, Iversen Marie H., Stiris Tom, Saugstad Ola D., Baumbusch Lars O., Andresen Jannicke H.   +6 more
doaj   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

PROTECTIVE EFFECTS OF SPIRULINA MICROALGAE AGAINST ADOLESCENT STRESS-INDUCED OXIDATIVE STRESS, BRAIN-DERIVED NEUROTROPHIC FACTOR ALTERATIONS AND MORPHOLOGICAL REMODELING IN THE PREFRONTAL CORTEX OF ADULT FEMALE RATS

, 2023
Nasrollah Moradikor, Motahareh Haghipanah, Ali Rashidy‐Pour   +2 more
openalex   +1 more source